News & Opinion

Covering the life sciences inside and out

Most Recent

Suicide gene therapy for colon cancer

By | February 14, 2002

Injection of suicide gene modified tumor cells induces a systemic antitumor response in a rat model of metastatic colon carcinoma.

0 Comments

Building brand new kidneys

By | February 13, 2002

Advanced Cell Technology has sparked yet more controversy with its claim to have grown kidney-like organs.

0 Comments

Cloning from lymphocytes

By | February 13, 2002

Cloning animals from nuclei that are genetically marked by terminal differentiation remains inefficient, with most clones dying during gestation. In February 10 online Nature, Konrad Hochedlinger and Rudolf Jaenisch from Massachusetts Institute of Technology, Cambridge, USA, show that monoclonal mice can be generated by nuclear transfer from mature B and T donor cells. Hochedlinger & Jaenisch transferred nuclei from peripheral lymph node cells of mice into enucleate oocytes. From the resulti

0 Comments

Time control

By | February 13, 2002

The mammalian circadian clock is based on autonomous rhythmic expression of several clock genes in the pituitary gland, but how these signals are disseminated into the periphery remains unclear. In February 11 online Nature Neuroscience, Charlotte von Gall and colleagues from Johann Wolfgang Goethe-University, Frankfurt, Germany, show that rhythmic gene expression in the pituitary is linked with the release of the neurohormones melatonin and prolactin.von Gall et al. used rodent pituitary cells

0 Comments

Vasculature mapping

By | February 13, 2002

A few years ago Renata Pasqualini and Erkki Ruoslahti developed an in vivo selection method to identify peptides that target specific vascular beds following intravenous administration of random peptide phage-display libraries in mice. In the February issue of Nature Medicine, Pasqualini's group at the MD Anderson Cancer Center in Texas report the application of 'in vivo phage display' to characterize the human vasculature (Nat Med 2002, 8:121-127).They injected a large-scale, random peptide lib

0 Comments

Doing the genome shuffle

By | February 12, 2002

DNA shuffling mimics an accelerated evolutionary process that selects for improved individuals. DNA shuffling allows for recombination between multiple parents at each generation, resulting in 'complex progeny' and faster selection. In the February 7 Nature Ying-Xin Zhang and colleagues at Maxygen in California describe using a whole-genome shuffling approach to derive new bacterial strains (Nature 2002, 415:644-646).They chose to shuffle Streptomyces, used to produce commercial antibiotics. Zha

0 Comments

Early detection of ovarian cancer with proteomic patterns

By | February 12, 2002

Computer-assisted detection of proteomic patterns identifies types of ovarian cancer and could help screen high-risk populations.

0 Comments

'Off-switch' for systemic inflammation

By | February 11, 2002

, a transcription factor activated by the IL-6 family of cytokines, has a critical role in the control of systemic inflammation.

0 Comments

Cool sensations

By | February 11, 2002

Cold sensation has a specific receptor but can also be produced by coordinated action of several different ion channels.

0 Comments

Radiation risks

By | February 11, 2002

In the February 8 Science, Yuri Dubrova and colleagues reported a study of the genetic risk of ionizing radiation to humans (Science 2002, 295:1037). They studied blood samples from 40 three-generation families living near the Semipalatinsk nuclear test site in Kazakhstan; they looked at eight hypervariable minisatellite probes and compared mutation rates with matched control samples.Dubrova et al., found a statistically significant 1.8-fold increase in the mutation rate of the exposed populatio

0 Comments

Popular Now

  1. The Meaning of Pupil Dilation
    Daily News The Meaning of Pupil Dilation

    Scientists are using pupil measurements to study a wide range of psychological processes and to get a glimpse into the mind.

  2. Exercise-Induced Muscle Factor Promotes Memory
  3. Illustrating #FieldworkFails
  4. Transmissible Cancers Plague Mollusks
Biosearch Technologies