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Plant defense dissected

By | April 2, 2002

Calmodulin interacts with the protein MLO to control the defense mechanism against mildew in barley.

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Senescence tale

By | April 2, 2002

Replicative senescence is associated with telomere shortening and the loss from the ends of chromosomes of about 100 bp per population doubling. In March 19 Science, Jan Karlseder and colleagues at Rockefeller University claim that the state of the ends, rather than telomere loss, determines the induction of senescence (Science 2002, 295:2446-2449).Karlseder et al. studied primary human fibroblasts expressing TRF2, a sequence-specific DNA-binding protein that binds to telomeric repeats. TRF2 ove

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Divine DNA repair

By | March 28, 2002

The Artemis protein cuts away damaged DNA to enable the strands to be rejoined.

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MicroRNAs

By | March 28, 2002

Large families of RNA molecules of 21-22 nucleotides, called microRNAs, have been found in a number of species. In an Advanced Online Publication from Nature Genetics, Eric Lai from the University of California at Berkeley, describes a family of microRNAs in Drosophila (Nat Genet 2002, DOI:10.1038/ng865).He found that 11 Drosophila microRNAs are complementary to the K-box motif (cUGUGAUa), Brd box (AGCUUUA) and GY box (uGUCUUCC) motifs present in the 3' untranslated regions (UTRs) of several bas

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Biomarker for Alzheimer's disease

By | March 27, 2002

efflux may be used as a measure of brain amyloid load in Alzheimer's disease.

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Cesar Milstein dies

By | March 27, 2002

sar Milstein, who pioneered monoclonal antibody technology, has died.

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Small genomes are still shrinking

By | March 27, 2002

genome is still shrinking toward a minimum set of genes necessary for its symbiotic lifestyle.

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Tissue transcriptomes

By | March 27, 2002

In the Early Edition of the Proceedings of the National Academy of Sciences, Andrew Su and collaegues describe high-throughput gene-expression analysis of the mouse and human transcriptomes in different tissues (Proc Natl Acad Sci USA 2002, 10.1073/pnas.012025199).Su etal. performed oligonucleotide hybridisation experiments on samples from 46 human and 45 mouse tissues of diverse origin. They found that 6% of genes are ubiquitously expressed, and individual samples express 30-40% of genes; almos

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Arabidopsis

By | March 26, 2002

Now that the Arabidopsis thaliana genome has been sequenced, plant biologists are turning their efforts to genome annotation. In a 21 March report on the Sciencexpress website, Motoaki Seki and colleagues from the RIKEN Institute in Japan, describe a large-scale analysis of full-length Arabidopsis cDNA libraries (Sciencexpress 2002 10.1126/science.1071006).Seki et al. isolated over 150,000 RIKEN Arabidopsis Full-Length (RAFL) cDNA clones, sequenced the ends and clustered them into almost 15,000

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Europe boosts post genomic research

By | March 26, 2002

25 million to three pan European post genomic projects signals a shift in EU funding of science.

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