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Covering the life sciences inside and out

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No link between mumps and inflammatory bowel disease

By | May 18, 2001

Mumps virus DNA could not be detected in intestinal specimens or peripheral blood lymphocytes from patients with inflammatory bowel disease.

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Nottingham's smoking gun

By | May 18, 2001

Editor from his post at Nottingham University inprotest at tobacco industry funding has ignited a fierce debate over ethicsand impartiality in medical research.

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Horizontal transfer of tumorigenesis

By | May 17, 2001

Apoptotic bodies are rapidly cleared in the body by phagocytosis. In the May 22 Proceedings of the National Academy of Sciences, Bergsmedh et al. provide evidence that the uptake of apoptotic bodies can deliver oncogenes to the phagocytotic host cell (Proc Natl Acad Sci USA 2001, 98:6407-6411). They could detect the horizontal transfer of H-rasV12 or c-myc oncogenes from dying, transformed rat fibroblast cells to recipient mouse fibroblasts. DNA transfer was detected by PCR analysis and fluoresc

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Mining the mouse

By | May 17, 2001

Despite the announcement of draft mouse genome sequences, it will be some time before a credible mouse genome is established.

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Obesity weighs in as major cancer cause

By | May 17, 2001

Obesity is the single most important cause of cancer among non-smokers, concludes a major review of research carried out over the last 50 years. But the nature of the relationship remains unclear and the benefits of dieting are unknown.In 17 May Nature Julian Peto from the Institute of Cancer Research, Surrey points out that tobacco remains the biggest health risk by far, causing cancer in 60% of smokers. Other causes include alcohol, sunlight and air pollution, each responsible for about 1% of

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Permanent memory

By | May 17, 2001

-calcium-calmodulin kinase II is required for consolidation of memory.

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Biomedical researchers in the UK breathed a sigh of relief this week as a new law lifted the threat of the data protection regulations. But can research without patient consent continue as before?

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Corneal healing through apoptosis

By | May 16, 2001

The Arthus type allergic reaction in the cornea is characterised by inflammatory cell infiltration and marked neovascularisation. This gradually disappears during the healing stages through mechanisms that are not yet elucidated but which are essential to preserve vision. In the May British Journal of Ophtalomology, Noriko Ozaki and colleagues from the Nippon Medical School, Tokyo show that regression of the Arthus reaction in the cornea occurs via apoptosis.Ozaki et al injected bovine serum alb

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Reactivating liver genes

By | May 16, 2001

functions in the developmental control of methylation and chromatin remodelling.

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A human urate transporter data sheet

By | May 15, 2001

High serum levels of uric acid are associated with an increased risk of developing gout, hypertension, cardiovascular disease and renal failure. Urate is produced as a result of purine degradation and as yet little is known about the pathway for urate efflux from cells. In the May Journal of Clinical Investigation Michael Lipkowitz and colleagues from the Mount Sinai School of Medicine, New York provide data on the human urate transporter galectin 9.Lipkowitz et al show that a recombinant protei

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