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Which antiretrovirals?

By | November 28, 2001

There are currently 17 different antiretroviral drugs available for the treatment of HIV, but the efficacy of a specific drug for a particular individual is very difficult to predict. In November 24 Lancet Michael Polis and colleagues from the National Institute of Allergy and Infectious Diseases, Bethesda, US, show that changes in HIV-1 concentration at day 6 after the start of antiretroviral treatment is a good early measure of individual long-term responses.Polis et al. analysed the kinetics

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Dendritic vaccination for HIV patients

By | November 27, 2001

, a frequent opportunistic infection of immunocompromised hosts.

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Type I diabetes protective peptide

By | November 27, 2001

A modified cell surface peptide could herald a breakthrough in the treatment of autoimmune diseases.

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Arsenic and old telomerase

By | November 26, 2001

Although arsenic is effective in the treatment of acute promyelocytic leukemia it also has carcinogenic side effects, but the exact carcinogenic mechanisms remain unclear. In November Journal of Clinical Investigation Wen-Chien Chou and colleagues from Johns Hopkins University School of Medicine, Baltimore, US show that at clinically relevant doses arsenic inhibits the transcription of the reverse transcriptase subunit of the human telomerase gene (hTERT).Chou et al. found that exposing NB4 leuk

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Limited variation

By | November 26, 2001

Small differences in DNA sequence are thought to account for the wide variation between people. In the November 23 Science, Nila Patil and researchers at Perlegen Sciences Inc. in California, suggest that the differences might be less than we had thought (Science 2001, 294:1719-1723).They set out to map a large number of common single nucleotide polymorphisms (SNPs) on human chromosome 21 and to define their haplotype structure. They took a panel of 24 individuals and used a rodent-human somatic

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Never the European twain shall meet

By | November 26, 2001

Despite months of consultation the UK and the EU remain divided over therapeutic cloning.

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Genomic systems biology

By | November 23, 2001

Identifying genes linked to complex multifactorial diseases presents a formidable challenge for the post-genomic era. In the November 23 issue of Science, Monika Stoll and researchers at the Medical College of Wisconsin in Milwaukee describe a 'physiological profiling' strategy to investigate systems biology (Science 2001, 294:1723-1726).They measured 239 cardiovascular and renal phenotypes, during normal and stressed conditions, in 113 male rats derived from an F2 intercross. They could map 81

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Parasites bare all

By | November 23, 2001

The completion of a microsporidian parasite genome could have important implications for microbial comparative genomics.

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Skin antibiotics

By | November 23, 2001

Cathelicidin and dermicin are antimicrobial proteins that enhances skin defense against invasive bacteria.

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Anthrax attacks highlight holes in US public health system

By | November 22, 2001

The bioterrorist activity in the United States has identified significant gaps in the supposed seamless and coherent response to major public health emergencies.

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