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Making sense of antisense

By | August 20, 2001

DNA microarray analysis has been used to define gene-expression profiles following treatment with antisense oligonucleotides.

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HIV confuses specific B cell subset

By | August 17, 2001

Antibody-producing B cells begin to malfunction early after infection with HIV, for reasons that are poorly understood. In August 14 on-line Proceedings of the National Academy of Sciences Susan Moir and colleagues from National Institute of Allergy and Infectious Diseases, Bethesda, US show that HIV viremia induces the appearance of a subset of B cells whose function is impaired and which may be responsible for the hypergammaglobulinemia associated with HIV disease.Moir et al. studied the funct

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Humans easier to clone than sheep

By | August 17, 2001

In humans genomic imprinting for M6P/IGF2R is absent suggesting that humans could be technically easier to clone than sheep and other nonprimates.

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Proof of trans-splicing

By | August 17, 2001

It has been proposed that isoforms of Drosophila mod(mdg4) result from the trans-splicing of independent mRNA transcripts derived from both anti-parallel DNA strands. In the August 14 Proceedings of the National Academy of Sciences, Rainer Dorn and researchers at the Martin Luther University, Halle, Germany, provide proof for trans-splicing of mod(mdg4) transcripts in transgenic flies (Proc Natl Acad Sci USA 2001, 98:9724-9729).They characterized 26 different classes of mod(mdg4) transcripts all

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Antibodies that could cure prion diseases

By | August 16, 2001

Recombinant prion protein-specific Fab D18 antibodies inhibit prion propagation and clear cell cultures of infectious prions.

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Brainy stem cells

By | August 16, 2001

The search is on to identify and locate neural stem cells (NSCs). In the August 16 issue of Nature, Rodney Rietze and colleagues at The Walter and Eliza Hall Institute for Medical Research Australia, report the isolation of a pluripotent stem cell population from mouse brains (Nature 2001, 412:736-739).They performed a series of enrichment steps to purify NSCs from the ependymal and subventricular zones of the lateral ventricular walls. Flow cytometry was used to select a population expressing l

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The sweet taste of success

By | August 16, 2001

The perception of sweet taste has fascinated philosophers, cooks and scientists for centuries, but the molecular mechanisms involved in taste perception remained elusive. In August 10 Cell, Greg Nelson and colleagues from the University of California at San Diego, La Jolla, US dissect the signal detection of taste and report the characterization of new mammalian sweet receptors present on the cells of the tongue and palate.Nelson et al. developed transgenic rescue experiments to prove that the S

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A pathway to therapeutic destruction

By | August 15, 2001

via caspase-1dependent mechanisms.

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Hope for CJD sufferers

By | August 15, 2001

Drugs already licensed for the treatment of malaria and schizophrenia could be used to treat vCJD.

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Transcriptional switch

By | August 15, 2001

Ordered acetylation of the HMGI(Y) protein controls enhanceosome stability and switches on gene expression.

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