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Intronic sequences

By | September 28, 2001

We are far from understanding all the rules that govern the process of RNA splicing and defining the sequence information that governs intron definition. In the September 25 Proceedings of the National Academy of Sciences, Lee Lim and Christopher Burge at the Massachusetts Institute of Technology, Cambridge, USA, describe a computational approach for investigating intron splicing (Proc Natl Acad Sci USA 2001, 98:11193-11198).They chose transcripts from five eukaryote genomes (Saccharomyces cerev

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Chemical behind exercise 'lift' discovered

By | September 27, 2001

The mystery over the antidepressant effects of physical activity may have finally been solved.

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Negative regulator of B cell function

By | September 27, 2001

A newly identified Btk-interacting protein, IBtk, binds to the PH domain of Btk and downregulates Btk function in B cells.

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Study points to new genetic model for disease

By | September 27, 2001

Biedel syndrome, a classically Mendelian genetic disease is triallelic.

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Viral discovery

By | September 27, 2001

The isolation of novel viral genomes from serum or plasma samples presents a significant technical challenge. In the September 25 Proceedings of the National Academy of Sciences, Tobias Allander and colleagues at the National Institute of Allergy and Infectious Diseases, Bethesda, USA, describe a sensitive method for identifying viruses in serum samples (Proc Natl Acad Sci USA 2001, 98:11609-11614).The method is based on the fact that viral genomes are generally protected from DNase degradation

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A link between Alzheimer's and Parkinson's disease

By | September 26, 2001

The proteins associated with Alzheimer's disease and Parkinson's disease interact to enhance each other's distinct degenerative effects

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Minos in mammals

By | September 26, 2001

Transposon-based technology for insertional mutagenesis of the genome has been widely used in Drosophila and could be adapted for genomic analysis in mammals. Minos is a mobile element of the Tc1/mariner superfamily isolated from Drosophila hydrei. In the September 25 Proceedings of the National Academy of Sciences, Zagoraiou et al. report the use of Minos transposons in mouse tissues (Proc Natl Acad Sci USA 2001, 98:11474-11478).They generated two transgenic mouse lines: one expressing the Mino

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Modifying DiGeorge

By | September 26, 2001

Analysis of a mouse model for DiGeorge syndrome suggests that genetic modifiers affect the disease phenotype.

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Wave of schizophrenic brain loss uncovered

By | September 26, 2001

Schizophrenic teenagers undergo a wave of grey matter loss that envelopes increasing amounts of the cortex throughout adolescence.

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A fish a day keeps the doctor away

By | September 25, 2001

Changes in the diet of the Inuit people of Nunavik, Canada, help explain the beneficial effect of n-3 fatty acids on the key risk factors of cardiovascular disease.

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