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Caretakers and gatekeepers

By | March 14, 2001

Cellular gatekeepers include the proteins that regulate cell cycle progression in response to DNA damage, and the DNA repair pathways function as genomic caretakers. The p53 and ATM (ataxia-telangiectasia-mutated) proteins behave as cellular gatekeepers, whereas the non-homologous end-joining (NHEJ) DNA repair machinery acts as a genomic caretaker. NHEJ factors include Ku70, Ku80 and the DNA-PK enzyme, plus XXRC4 and DNA Ligase IV (Lig4), which function in ligation.In 6 March Proceedings of the

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Multiprotein DNA/MVA vaccine for AIDS

By | March 14, 2001

DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model.

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Neuron survival is not enough

By | March 14, 2001

Parkinson's disease is associated with the loss of dopamine neurons in the caudate and putamen nuclei of the brain. Several groups have tried to slow down the neuron loss by transplanting embryonic precursors of dopaminergic cells and obtained some promising results. In the 8 March issue of New England Journal of Medicine a team from University of Colorado School of Medicine, Denver, published the first double-blind placebo controlled study of the transplant therapy (N Engl J Med 2001, 344:710-7

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Genes controlling longevity

By | March 13, 2001

A gene that controls lifespan in yeast also regulates longevity in nematode worms.

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More data indicate no link between MMR and autism

By | March 13, 2001

1994, but this does not correlate with a small relative increase in the MMR immunization rate.

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Pasteur's genome

By | March 13, 2001

Pasteurella multocida causes disease in birds, cattle, swine and humans, but the mechanisms underlying its virulence are unknown. In the 6 March PNAS May and colleagues report the complete sequence of the Pasteurella multocida (Pm70) genome (PNAS 2001, 98:3460-3465).May et al used a shotgun strategy to sequence more than 53,000 DNA fragments and assemble them into a single circular sequence of about 2.26 Mb. The Pm70 genome contains 2,014 predicted coding regions, accounting for 89% of the entir

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Insulin resistance linked to CD36 deficiency

By | March 12, 2001

Insulin resistance is mainly characteristic for type 2 diabetes, a common disorder that is also a potent risk factor for coronary heart disease. Genetic associations with type 2 diabetes have recently been drawn, and genes underlying rare monogenic causes of insulin resistance have been identified. But the molecular basis of the common insulin resistance remains unknown.In 3 March Lancet, Koji Miyaoka and colleagues from Osaka University, Japan present evidence for insulin resistance in CD36-def

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Musical Twins

By | March 12, 2001

A study of mono- and dizygotic twins indicates that there is a strong genetic contribution to musical pitch perception.

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Protein folding

By | March 12, 2001

Under specific conditions globular proteins can assume a structure resembling amyloid and prion aggregates.

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genotype influences chemotherapy results

By | March 9, 2001

Oxidative stress has been implicated in the metabolism of chemotherapy drugs. The mechanisms have been linked to the genes that encode glutathione S-transferase (GST) which are critical in protection against oxidative stress.In March Journal of Clinical Oncology Stella Davies and colleagues demonstrate that presence or absence of GST genes may influence the outcome of treatment for childhood acute myeloid leukaemia (AML).Davies et al genotyped the GST isoenzyme genes GSTT1 and GSTM1 in 306 child

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