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ssDNA Tools

By | June 1, 2001

Single-stranded oligonucleotides may provide a new tool for homologous recombination and genome modification.

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Statins can block inflammation

By | June 1, 2001

LFA703, a statin with high binding affinity for the LFA-1 site but low activity against HMG-CoA reductase has increased anti-inflammatory effects.

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Training microarrays

By | June 1, 2001

Artificial neural networks can help in applying microarray data to tumour diagnosis.

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Complementary medicine under scrutiny

By | May 31, 2001

The establishment of a new research centre for complementary medicine at Harvard Medical School signals a growing interest in subjecting complementary therapies to scientific scrutiny.

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Error-prone polymerases make efficient immunity

By | May 31, 2001

the process behind increasing antibody affinities after multiple exposures to the same antigen.

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How retinoids kill leukaemic cells

By | May 31, 2001

Retinoid hormones can induce post-maturation apoptosis through the Apo-2L/TRAIL death ligand.

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Influencing influenza

By | May 31, 2001

Serial passaging in mouse lungs selects for virulent variants of influenza A virus that result from several mutations.

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DNase II and erythropoiesis

By | May 29, 2001

Deoxyribonuclease II (DNase II) is a lysosomal DNase that has been implicated in the degradation of DNA in apoptotic cells. In the May 25 Science, Kawane et al. report the analysis of mice lacking a functional DNase II protein (Science 2001, 292:1546-1549). No DNase II-null mice survived until birth. Mutant embryos developed anemia at embryonic days 12.4-14.5 and had dramatically reduced numbers of mature erythrocytes. Transplantation of DNase II-null fetal liver cells into irradiated mice gener

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Meticillin-resistance spread by horizontal gene transfer

By | May 29, 2001

Staphylococcus aureus.

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Biomarkers are better monitors for environmental pollution

By | May 25, 2001

Blood and urine biomarkers of renal dysfunction and DNA damage can be used to detect environmental exposure to pollutants and measure their biological effect before overt disease develops.

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