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Proteome purification

By | March 8, 2002

In the March 5 Proceedings of the National Academy of Sciences, Pascal Braun and colleagues describe a methodology to perform high-throughput purification of human proteins using several affinity-tags (Proc Natl Acad Sci USA 2002, 99:2654-2659).Braun et al. exploited the Gateway recombinational cloning system that employs a versatile 'master' vector for easy transfer into different expression vectors. They chose a test set of 32 human genes and expressed them in four different vectors with diffe

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Indomethacin inhibits CMV replication

By | March 7, 2002

Inhibitors of cyclooxygenase 2 block the replication of cytomegalovirus in human fibroblasts.

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Shotgun strategies

By | March 7, 2002

One year after the two human draft genome sequences were published the debate over sequencing strategies continues.

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US cloning debate gathers steam

By | March 7, 2002

US Senate debates bill aimed at banning both therapeutic and reproductive cloning.

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Cytomegalovirus control

By | March 6, 2002

The IE86 protein of human cytomegalovirus is an 'immediate early' viral protein that drives cells into S phase, but blocks cell division. In the March 5 Proceedings of the National Academy of Sciences, Yoon-Jae Song and Mark Stinski describe a microarray analysis of the effects of IE86 expression on the human transcriptome (Proc Natl Acad Sci USA 2002, 99:2836-2841).Song and Stinski infected human foreskin fibroblast cells with a replication-defective adenovirus encoding the IE86 protein, then i

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PRIMA facie evidence

By | March 6, 2002

The tumor suppressor p53 triggers cell-cycle arrest and apoptosis but about 50% of human tumors have mutations in p53 which makes them resistant to apoptosis. Vladimir Bykov and colleagues from Karolinska Institutet, Stockholm, Sweden hypothesized that restoring p53 in tumor cells could trigger massive apoptosis and eliminate the tumor. In March Nature Medicine, they show that a small molecule, called PRIMA-1, can restore the tumor suppressor function of p53 and have anti-tumor effects.Bykov et

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Chipping away at GATA

By | March 5, 2002

-globin locus.

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Human stem cell research gets green light

By | March 5, 2002

The first UK licenses for human embryonic stem cell research have been granted.

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Nanny state seeks new manacles

By | March 5, 2002

UK researchers fear that legislation debated on Monday in the House of Lords could infringe academic freedom.

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Protease inhibitors kill tumors

By | March 5, 2002

Protease inhibitors are potent anti-angiogenic molecules with direct anti Kaposi sarcoma and anti-tumor activity.

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