Stress-related genes may be preferentially and rhythmically expressed as part of the circadian rhythms of older fruit flies, researchers report.
April 22, 2002|
The protein kinase Akt promotes cell survival by phosphorylating and inhibiting FOXO forkhead transcription factors. FOXO factors have been linked to stress responses and the regulation of longevity. In the April 19 Science, Hien Tran and colleagues at Boston's Children's Hospital define a role for the FOXO3a family member in the response to DNA damage (Science 2002, 296:530-534).Tran et al. created a Rat-1 fibroblast cell line expressing a tamoxifen-inducible FOXO3a protein. FOXO3a expression r