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Mitochondrial inheritance

By | September 6, 2001

In September 6 Nature, Sofia Berlin and Hans Ellegren from Uppsala University, Sweden, examine the controversial clonal inheritance theory for vertebrate mitochondrial DNA (mtDNA) by following co-inheritance of a female-specific nuclear DNA marker (Nature 2001, 413:37-38).They examined the avian W chromosome, most of which is non-recombining and therefore clonally transmitted by females. A polymorphic (CA)n repeat, NVHfp49, on the W chromosome of 53 female peregrine falcons (Falco peregrinus) an

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stem cells to become blood

By | September 6, 2001

The potential of embryonic stem cells to develop into a wide variety of tissues and organs has been established, but it remains unclear how this can be achieved in practice. In 4 September Proceedings of the National Academy of Sciences, Dan Kaufman and colleagues at the University of Wisconsin-Madison show for the first time how undifferentiated human embryonic stem cells (ES) can be cultured to become blood cells.Kaufman et al. cultured ES in flasks containing murine bone marrow cell line S17

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will require constant innovation

By | September 6, 2001

resistant to vancomycin and now linezolid illustrates the urgent need for novel antibiotic design strategies.

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Following the cancer trail

By | September 5, 2001

Aggressive melanoma cells leave a molecular trail in the extracellular matrix enabling less aggressive cells to become more aggressive.

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Protecting colonic mucosa

By | September 5, 2001

Short-chain fatty acids protect colonic mucosa against oxidant-induced stress through inducing expression of hsp25.

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Career counselling for embryonic cells

By | September 4, 2001

In an embryo, the stem cells develop into specific organs under the influence of complex extracellular signals. Sonic hedgehog (Shh) plays an important role in this process but its signalling pathway is not entirely understood. In August 31 Science Gurtej Dhoot and colleagues from the University of Pennsylvania Medical Center identify a member of a family of conserved sulfatases, QSulf1, which is responsive to Shh signaling and has role in embryonic cell fate determination.Dhoot et al. identifie

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Glutamate fuels brain tumor growth

By | September 4, 2001

Glutamate is one of the principal neurotransmitters in the brain, but in excess can be highly neurotoxic. In September Nature Medicine Takahiro Takano and colleagues from the New York Medical College, Valhalla, New York, show that in addition to being neurotoxic, glutamate release from glioma cells also promotes growth of malignant gliomas.Takano et al. used bioluminescence to detect glutamate release from freshly prepared brain slices. They found that implanted glioma cells continue to secrete

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throughput SIN-ning

By | September 4, 2001

A new expression cloning method based on SIN replicon particles from the Sindbis alphavirus promises high-throughput mammalian expression cloning.

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Gene profiling of immune communications

By | September 3, 2001

Early after bacterial invasion dendritic cells express IL-2, providing activation signals greatly enhancing both T and B cell responses.

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Setback for UK Synchrotron facilities, as new head takes over

By | September 3, 2001

The closure of the Daresbury synchrotron for emergency repairs emphasises the need for more of these facilities.

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