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An improved cancer model

By | April 26, 2001

A mouse strain has been generated in which K-ras alleles are activated at random, mimicking the sporadic occurrence of K-ras mutations in human cancers.

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Eaten by Daddy

By | April 26, 2001

There is no genetic evidence for filial cannibalism, in which parents eat their own offspring. In the April 24 Proceedings of the National Academy of Sciences, DeWoody et al. document filial cannibalism in fish in nature (Proc Natl Acad Sci USA 2001, 98:591-596). The authors captured male fish, of the tessellated darter and two sunfish species, and examined the cannibalized contents of the stomachs of nest-guarding males by polymorphic microsatellite marker analysis. They found that 10 out of 11

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The origin of HIV-1

By | April 26, 2001

Three independent studies quash the theory that experimental polio vaccines administered in Central Africa in the 1950s were the origin of the AIDS pandemic.

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Disruption in oligodendrocyte function indicated in schizophrenia

By | April 25, 2001

Myelin sheaths are critical for efficient signal transmission along axons. Their inactivation could explain some of the neuropathological deficits associated with schizophrenia.In the April 10 Proceedings of the National Academy of Sciences Yaron Hakak and colleagues of the Genomics Institute of the Novartis Research Foundation, San Diego, California used DNA microarray analysis to compare the gene-activation profiles in the postmortem dorsolateral prefrontal cortex of 12 schizophrenic and 12 no

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Interleukin-2 receptor can predict cancer outcome

By | April 25, 2001

High serum concentrations of the alpha chain IL-2 receptor are highly correlated with a shorter survival of patients diagnosed with head and neck squamous-cell carcinoma.

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New protease inhibitors against Alzheimer's disease

By | April 24, 2001

protein but did not affect the endoproteolysis of presenilins involved in cell defence.

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Regeneration of damaged axons

By | April 24, 2001

Sites of injury to the central nervous system can be treated with chondroitinase ABC to clear the path for axon regeneration.

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Rhythm disorder alleles

By | April 24, 2001

The genes that regulate circadian rhythms have been genetically characterized in flies and mice. In the April issue of EMBO Reports, Ebisawa et al. describe a screen for genetic polymorphisms associated with human circadian rhythm disorders (EMBO Reports 2001, 2:342-346). They performed a PCR-based analysis of the human period3 gene (hPer3), a homolog of a Drosophila clock gene, and identified 20 sequence variations, of which six predicted amino acid changes. Ebisawa et al. defined four haplotyp

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same difference

By | April 23, 2001

Honeybees are capable of cognitive performances thought to occur only in vertebrates.

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Sweet success

By | April 23, 2001

now a candidate receptor gene has been identified.

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