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The necrotizing gene

By | January 16, 2002

-hemolytic group G streptococcus can cause necrotizing fasciitis due to the presence of a functional homologue of streptolysin S.

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Chewing the fat

By | January 15, 2002

, regulates lipid metabolism in mice.

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Lactose intolerance DNA

By | January 15, 2002

A DNA variant upstream of the lactase-phlorizin hydrolase gene is associated with lactose intolerance.

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p53 mysteries

By | January 15, 2002

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational modifications (phosphorylation and acetylation) induced by genotoxic stress affect the DNA binding affinity of p53. In the January 8 issue of Proceedings of the National Academy of Sciences, Kaeser and Iggo suggest that such models should be reassessed in light of their results using chromatin immunoprec

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Endopeptidase modulated autoimmunity

By | January 14, 2002

Dominant myelin basic protein epitopes prevents autoimmunity and can be hidden from T cells by the action of asparagine endopeptidase.

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Finding the bug in the system

By | January 14, 2002

Computational subtraction uses the human genome to detect possible microbial causes for infectious diseases.

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Genetics of progressive osseous heteroplasia

By | January 14, 2002

mutations cause progressive osseous heteroplasia.

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Keeping an eye on gene expression

By | January 14, 2002

The retina contains neuronal cells (including photoreceptors) and non-neuronal retinal pigment epithelium (RPE). In January 8 Proceedings of the National Academy of Sciences, Dror Sharon and colleagues at Harvard Medical School describe characterisation of gene expression profiles in the human eye using the SAGE (serial analysis of gene expression) technology (Proc Natl Acad Sci USA 2002, 99:315-320).They prepared SAGE libraries from the peripheral retina, the macula and the RPE of two individua

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Placebo response not all in the mind

By | January 11, 2002

Imaging the brain during drug or placebo treatment for depression shows different but similarly effective responses.

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Py235 profiles

By | January 11, 2002

The Plasmodium yoelii yoelli genome contains around 35 genes encoding 235 kD rhoptry proteins (Py235) that are involved in erythrocyte invasion and parasite virulence. In the January 11 issue of Science, Preiser et al. describe the transcription pattern of py235 genes during the parasite's life cycle and their role in cell invasion (Science 2002, 295:342-345).Immunofluorescence analysis using antibodies recognizing distinct Py235 proteins revealed differences between pre-erythrocytic and erythro

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