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Somatic hypermutation

By | June 18, 2002

Experiments in fibroblasts have identified an enzyme that induces hypermutation resembling the hypermutator of immunoglobulin genes in lymphocytes.

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Transcription groupies

By | June 18, 2002

genome contains many large groups of adjacent genes that are expressed similarly but are not functionally related.

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Epo shades protection

By | June 17, 2002

Erythropoietin is upregulated in the hypoxic retina and protects against light-induced retinal degeneration.

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genomes

By | June 17, 2002

strains led to the discovery of a pathogenicity island important in antibiotic resistance.

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Potent thymic epithelial precursors

By | June 17, 2002

MTS24 embryonic thymic epithelial cells can fully reconstitute the complex thymic epithelial microenvironment.

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BRCA2 loss in Fanconi Anemia

By | June 14, 2002

Fanconi Anemia (FA) is a recessive cancer susceptibility syndrome. Six FA genes have been cloned and encode proteins involved in a DNA-damage response pathway. In the June 13 ScienceXpress, Niall Howlett and colleagues report the characterization of mutations in cells from the FA subtypes B and D1 (ScienceXpress 2002, DOI:10.1126/science.1073834).They discovered biallelic mutations in the BRCA2 breast cancer susceptibility gene; the mutations create frameshifts resulting in truncated BRCA2 prote

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Neuron survival kit

By | June 14, 2002

The insulin growth factor 1/Akt pathway is neuroprotective in Huntington's disease and is mediated by direct phosphorylation of huntingtin.

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Anopheles

By | June 13, 2002

Anopheles gambiae is the mosquito vector that is responsible for the transmission of malaria across Africa. In the June 11 Proceedings of the National Academy of Sciences, Dana Thomasová and colleagues report the sequencing of bacterial artificial chromosomes (BACs) covering over 500 kilobases from the Pen1 locus within the 8C region of A. gambiae chromosome 2R (Proc Natl Acad Sci USA 2002, 99:8179-8184).Sequence analysis led to the identification and annotation of 48 genes (46 encoding pro

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Biotech market will rebound

By | June 13, 2002

Biotech investment banker predicts market will rebound and tips systems biology as hot area for investment.

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Cloning steps sideways

By | June 13, 2002

Short on votes, US Senate cloning opponent considers proposing a two-year moratorium.

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