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DOCK2 controls lymphocyte migration

By | August 28, 2001

The exit of lymphocytes from the vasculature is essential for the control of the inflammatory response. Cell migration involves cytoskeletal dynamics controlled by Rac GTPases but the full molecular mechanism remains unknown. In August 23 Nature, Yoshinori Fukui and colleagues from Kyushu University, Japan, show that DOCK2, a haematopoietic cell-specific protein, mediates cytoskeletal reorganization via Rac activation and is indispensable for lymphocyte chemotaxis.Fukui et al. studied DOCK2-defc

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Hazards of aging

By | August 28, 2001

In the August 28 Proceedings of the National Academy of Sciences, Michelle Hamilton and colleagues, at the University of Texas Health Sciences Center, have addressed the question 'Does oxidative damage to DNA increase with age?' (Proc Natl Acad Sci USA 2001, 98:10469-10474).They set out to confirm the 'oxidative stress hypothesis' which postulates that aging results from the irreversible accumulation of oxidative damage. They isolated nuclear DNA (nDNA) and mitochondrial DNA (mtDNA) from multipl

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Multiple functions of the Kras2 oncogene

By | August 28, 2001

oncogene suppresses lung tumor formation and progression in mice.

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African elephants

By | August 24, 2001

African elephants are often considered to represent a single species, Loxodonta africana, which is distinct from the Asian elephant genus Elephas. In the August 24 Science, Alfred Roca and colleagues from the US National Cancer Institute challenge this assumption by presenting their results of a phylogenetic analysis of African elephants (Science 2001, 293:1473-1477).They collected dart-biopsy samples from almost two hundred free-ranging elephants from 21 populations and sequenced 1732 nucleotid

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Specialized skeletal structures enable brittlestars to 'see'

By | August 24, 2001

Brittlestars are marine echinoderms that characteristically have five long, thin arms radiating from a disc-shaped body. In August 23 Nature Joanna Aizenberg and colleagues at Bell Laboratories/Lucent Technologies, New Jersey, The Weizman Institute of Science, Israel and the Natural History Museum, Los Angeles describe the structure of unusual skeletal structures that could act as a compound eye.Despite having no eyes it has long been observed that brittlestars of the genus Ophiocoma wendtii can

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The molecular signature of prostate cancer

By | August 24, 2001

The use of cDNA microarray screening is enabling more accurate analysis of prostate tissue for signs of abnormality.

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Vaccination following spinal cord injury limits paralysis

By | August 24, 2001

Spinal cord injury results in a massive loss of neurons. It has been suggested that passive transfer of autoimmune T cells directed against myelin-associated antigens provides the spinal cord with effective neuroprotection. In August 15 Journal of Clinical Investigation, Ehud Hauben and colleagues from The Weizmann Institute of Science, Rehovot, Israel show for the first time a vaccination protocol that can be used as a strategy to prevent total paralysis after incomplete spinal cord injury.Haub

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Beware a conflict of interest

By | August 23, 2001

has asked contributors to declare potential conflicts of interest, including disclosure of sources of funding.

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goes live on the Internet

By | August 23, 2001

genome is now freely available on the web.

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MAPK signaling in psoriasis

By | August 23, 2001

Psoriasis is characterized by hyperproliferation of keratinocytes and increased expression of integrins, but the pathological signaling pathway remains unknown. In August 15 Journal of Clinical Investigation, Ingo Haase and colleagues from the Imperial Cancer Research Fund, London, UK show that activation of mitogen-activated protein kinase (MAPK) pathway by integrins, either directly or through increased IL-1 production, is responsible for epidermal hyperproliferation in psoriasis and wound hea

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