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More healing with stem cells

By | April 12, 2001

Intravenous infusion of bone-derived marrow stromal cells can enter the brain and reduce neurological functional deficits after stroke.

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Rehabilitation of brain function by relearning specific skills

By | April 12, 2001

Commonly, people who suffer attention deficits following brain injury due to trauma or stroke are treated using cognitive exercises designed to directly restore impaired attention processes.But Norman Park (Baycrest Centre for Geriatric Care, Toronto) and Janet Ingles (Dalhousie University, Nova Scotia) found that an alternative and lesser-used therapy may be more effective. They compared two different approaches to treatment. "One is restoration-training-based approach, which assumes you can re

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Genetic susceptibility of pre-eclampsia

By | April 11, 2001

A gene defect in the detoxifying enzyme epoxide hydrolase is associated with pre-eclampsia in pregnancy.

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New technology reduces the profitability for new drugs

By | April 11, 2001

The recent American College of Cardiology meeting provided a striking example of how the new technology of combinatorial chemistry is changing the face of the drugs market.

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Second-generation microarrays

By | April 11, 2001

Current microarray analysis uses 'chips' containing either 25-residue oligonucleotides synthesized by photolithography or cDNAs placed by robotic spotting. In the April Nature Biotechnology, Hughes et al. describe a microarray technique that exploits an ink-jet printing method and standard phosphoramidite chemistry (Nature Biotechnology 2001, 19:342-347). The ink-jet synthesizer can deliver 25,000 phosphoramidite-containing microdroplets to a 25 x 75 mm glass slide. Hughes et al. examined a larg

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Viral discovery gives new hope for schizophrenia sufferers

By | April 11, 2001

Retroviral genes inserted into the human genome may contribute to some cases of schizophrenia.

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Eotaxin role in gastrointestinal inflammation

By | April 10, 2001

Eosinophils have been implicated in the pathogenesis of gastrointestinal inflammation but the signalling processes involved in the accumulation of eosinophils have not been fully established. In the April Nature Immunology Simon Hogan and colleagues from the Children's Hospital Medical Center, Cincinnati, US and the Australian National University, Canberra describe the pathological consequences of eosinophilic inflammation and the involvement of eotaxin in the accumulation of eosinophils in the

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Lipotoxic cardiomyopathy dissected

By | April 10, 2001

Inherited defects in the mitochondrial fatty acid oxidation pathway can lead to lipotoxic cardiomyopathy and sudden death in children and young adults. The exact chain of pathologic events remains unknown, but in the 1 April Journal of Clinical Investigation Hsiu-Chiang Chiu and colleagues from Washington University School of Medicine describe the development of a murine model of metabolic cardiomyopathy. The study also suggests that lipotoxic cardiomyopathy is based on a mismatch between myocar

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Long-lived flies

By | April 10, 2001

Mutations that increase the life span of Caenorhabditis elegans encode components of the insulin/IGF signalling pathway. In the April 6 Science, two papers describe mutations that link insulin signaling with longevity in Drosophila melanogaster. Clancy et al. report that homozygous null mutations in chico, encoding an insulin receptor substrate protein, increased the female fly life span by up to 48% (Science 2001, 292:104-106). They were able to demonstrate that the effects of chico on longevit

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Genetic predisposition for osteoporosis

By | April 9, 2001

COL1A1 Sp1 polymorphism predisposes osteoporosis by mechanisms involving changes in bone mass and bone quality.

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