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Proof of trans-splicing

By | August 17, 2001

It has been proposed that isoforms of Drosophila mod(mdg4) result from the trans-splicing of independent mRNA transcripts derived from both anti-parallel DNA strands. In the August 14 Proceedings of the National Academy of Sciences, Rainer Dorn and researchers at the Martin Luther University, Halle, Germany, provide proof for trans-splicing of mod(mdg4) transcripts in transgenic flies (Proc Natl Acad Sci USA 2001, 98:9724-9729).They characterized 26 different classes of mod(mdg4) transcripts all

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Antibodies that could cure prion diseases

By | August 16, 2001

Recombinant prion protein-specific Fab D18 antibodies inhibit prion propagation and clear cell cultures of infectious prions.

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Brainy stem cells

By | August 16, 2001

The search is on to identify and locate neural stem cells (NSCs). In the August 16 issue of Nature, Rodney Rietze and colleagues at The Walter and Eliza Hall Institute for Medical Research Australia, report the isolation of a pluripotent stem cell population from mouse brains (Nature 2001, 412:736-739).They performed a series of enrichment steps to purify NSCs from the ependymal and subventricular zones of the lateral ventricular walls. Flow cytometry was used to select a population expressing l

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The sweet taste of success

By | August 16, 2001

The perception of sweet taste has fascinated philosophers, cooks and scientists for centuries, but the molecular mechanisms involved in taste perception remained elusive. In August 10 Cell, Greg Nelson and colleagues from the University of California at San Diego, La Jolla, US dissect the signal detection of taste and report the characterization of new mammalian sweet receptors present on the cells of the tongue and palate.Nelson et al. developed transgenic rescue experiments to prove that the S

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A pathway to therapeutic destruction

By | August 15, 2001

via caspase-1dependent mechanisms.

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Hope for CJD sufferers

By | August 15, 2001

Drugs already licensed for the treatment of malaria and schizophrenia could be used to treat vCJD.

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Transcriptional switch

By | August 15, 2001

Ordered acetylation of the HMGI(Y) protein controls enhanceosome stability and switches on gene expression.

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Exploiting the autoimmune response

By | August 14, 2001

Conjugation of a self-antigen to papillomavirus-like particles elicit high titers of autoantibodies that can be used to treat arthritis and other diseases.

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Heterochromatin boundaries

By | August 14, 2001

Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10 Science, Noma et al. define the boundaries of the heterochromatin domain at the mating-type locus (mat) in fission yeast (Science 2001, 293:1150-1155).They used chromatin immunoprecipitation (ChIP) and PCR analysis to scan the entire mat region (about 47 kilobases). Methylation of lysine 9 of histone H3 and the Swi6 protein were both enriched in a 20kb interval that contains the mat2/3 s

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Photobiology reduces the need for biopsies in bladder cancer

By | August 14, 2001

The photoactive protein protoporphyrin IX is more abundant in cancer cells, enabling ready identification of certain tumours.

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