NIH issues US embryonic stem cell guidelines, at last
| August 29, 2000
But November's presidential election is likely to determine whether US scientists will ever be able to do this work with taxpayer blessings - and money.
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Stem cell transplantation in SLE
August 29, 2000
NEW YORK, Aug 28 (Praxis Press). Despite immunosuppressive and other therapies, the annual mortality rate of systemic lupus erythematosus (SLE) remains about one percent. Traynor and colleagues studied the effects of high-dose cyclophosphamide treatment and autologous, haematopoietic stem cell transplantation in nine patients with severe, steroid-dependent SLE. Two patients developed infections (cytomegalovirus and mucormycosis) after stem cell harvest and were excluded from the study; seven pat
Alcoholism treatment
August 25, 2000
NEW YORK, August 25 (Praxis Press). Early-onset alcoholism (before age 25 years) is associated with serotonergic dysfunction, and individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent. To compare the effectiveness of ondansetron, a selective serotonin receptor antagonist, in the treatment of early-onset and late-onset alcoholism, Johnson and colleagues performed a double blind, randomized, placebo-controlled clinical trial. A total of 321 pati
Early low-fat diet doesn't harm development
| August 25, 2000
A low-fat, low-cholesterol diet in babies may protect against coronary heart disease in adulthood.
Estrogen and CHD
August 25, 2000
NEW YORK, August 25 (Praxis Press). Although coronary heart disease (CHD) is a major cause of illness and death in women, the role of estrogen in its treatment and prevention remains unclear. To examine this relationship, Herrington and colleagues randomized a total of 309 women with angiographically verified CHD to receive: 0.625 mg of conjugated estrogen per day; 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate per day; or a placebo. They then followed the women for a
Genes that provide tumors with blood
| August 25, 2000
In the 18 August Science St. Croix et al. present an expression analysis of endothelial cells from blood vessels of normal and malignant colorectal tissue (Science 2000, 289:1197-1202). After developing a method for purifying these scarce cells, they use serial analysis of gene expression (SAGE) to identify a host of new pan-endothelial markers that are not expressed in other tissues. Additionally, 46 SAGE tags are elevated tenfold or more specifically in tumor endothelium, and at least 7 of the
Link found between proteins responsible for Alzheimer's and vCJD
| August 25, 2000
A Chinese research team has described a 'striking similarity' between the proteins involved in the early stages of Alzheimer's disease and variant Creutzfeldt-Jakob disease.
London School's 20-fold grant increase covers DNA vaccines to politics
| August 25, 2000
Malaria should shiver at a new attack to be mounted against the disease.
Persistent bacterial infection and vascular disease
| August 25, 2000
Autoimmune reaction to infection could be an important factor in atherogenesis.
Abortion
August 24, 2000
NEW YORK, August 22 (Praxis Press). Studies have disagreed about the mental health risks associated with elective abortion, but few studies have followed women for long periods of time after abortion or have differentiated between negative emotions and clinically significant psychological distress. Major and colleagues prospectively evaluated emotions, attitudes, and mental health status in 442 women undergoing elective, first-trimester abortion. Two years after the abortion, the majority of wom
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