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Limited variation

By | November 26, 2001

Small differences in DNA sequence are thought to account for the wide variation between people. In the November 23 Science, Nila Patil and researchers at Perlegen Sciences Inc. in California, suggest that the differences might be less than we had thought (Science 2001, 294:1719-1723).They set out to map a large number of common single nucleotide polymorphisms (SNPs) on human chromosome 21 and to define their haplotype structure. They took a panel of 24 individuals and used a rodent-human somatic

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Never the European twain shall meet

By | November 26, 2001

Despite months of consultation the UK and the EU remain divided over therapeutic cloning.

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Genomic systems biology

By | November 23, 2001

Identifying genes linked to complex multifactorial diseases presents a formidable challenge for the post-genomic era. In the November 23 issue of Science, Monika Stoll and researchers at the Medical College of Wisconsin in Milwaukee describe a 'physiological profiling' strategy to investigate systems biology (Science 2001, 294:1723-1726).They measured 239 cardiovascular and renal phenotypes, during normal and stressed conditions, in 113 male rats derived from an F2 intercross. They could map 81

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Parasites bare all

By | November 23, 2001

The completion of a microsporidian parasite genome could have important implications for microbial comparative genomics.

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Skin antibiotics

By | November 23, 2001

Cathelicidin and dermicin are antimicrobial proteins that enhances skin defense against invasive bacteria.

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Anthrax attacks highlight holes in US public health system

By | November 22, 2001

The bioterrorist activity in the United States has identified significant gaps in the supposed seamless and coherent response to major public health emergencies.

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Genetic classification of lung tumors

By | November 22, 2001

DNA microarray studies of crudely dissected lung tumors can detect tumor subtypes that correlate with biological and clinical phenotypes.

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Radiation resistance

By | November 22, 2001

A screen of diploid yeast mutants has identified over a hundred genes involved in the response to ionizing radiation.

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Fly SNPs

By | November 21, 2001

genome will accelerate the rate of positional cloning in flies.

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Microbial biology to yield biomedical harvest

By | November 21, 2001

New initiatives launched by the US Department of Energy aim to extract practical benefits from the vast amount of microbial genomic data available.

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