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Covering the life sciences inside and out

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is a key signal for cancer treatment

By | October 5, 2001

signaling in T cells.

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The ADAMTS family

By | October 5, 2001

A deficiency in a member of the ADAMTS family of zinc metalloproteinases causes thrombotic thrombocytopenic purpura.

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Watch your language!

By | October 5, 2001

Several studies have suggested that there may be a genetic component to developmental disorders of speech and language, but no specific genes have been identified. In the October 4 Nature, Cecilia Lai and colleagues at the University of Oxford report mutations in a gene that correlates with such language disorders (Nature 2001, 413:519-522).Study of a family (called KE) with speech-language disorder led to the mapping of the SPCH1 locus on chromosome 7. Lai et al. performed fluorescence in-situ

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Cannabinoid protects injured brain

By | October 4, 2001

No effective drug currently exists to treat brain injury and the mechanisms that control post-trauma events remain largely unknown. In October 4 Nature, David Panikashvili and colleagues from the Hebrew University, Jerusalem, show that the cannabinoid, 2-arachidonoyl glycerol (2-AG) is part of an endogenous system that protects the brain in the period following traumatic injury.Panikashvili et al. observed that after closed head injury in mice the level of endogenous 2-AG was significantly eleva

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Fat-busting protein

By | October 4, 2001

The protein 4E-BP1 converts white adipose tissue into brown adipose tissue and consequently reduces obesity.

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Lack of confidence in the MMR vaccine affects immunization rates

By | October 4, 2001

report into a possible link between MMR and autism has resulted in fewer children being immunized.

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Plague genome

By | October 4, 2001

Yersinia pestis is a Gram-positive bacterium that has wreaked havoc for centuries by causing plague pandemics such as the Black Death. Threats that Y. pestis could be used as a biological warfare agent suggest that it will continue to provide a healthcare challenge in the future. In the October 4 Nature, Parkhill et al. from The Sanger Centre report the complete genome sequence of the Y. pestis strain CO92 (Nature 2001, 413:523-527).The killer genome consists of a 4.65 megabase chromosome and th

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A new mechanism for hypertension

By | October 3, 2001

Mitochondrial coupling factor 6 is a potent circulating endogenous vasoconstrictor, producing hypertension by suppressing prostacyclin synthesis.

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Making healthy new blood vessels

By | October 3, 2001

can induce the formation of new blood vessels that do not show signs of leakage or inflammation.

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pol II

By | October 3, 2001

plays a critical role during transcription by RNA polymerase II.

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