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End-joining in yeast

By | December 6, 2001

Two genes have been found to down-regulate the non-homologous end-joining pathway in meiotic diploid yeast cells.

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Out of this world physiology

By | December 6, 2001

The way in which the human body responds to the rigours of space flight is providing insights into Earthly physiology.

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The benefits of the waiting game

By | December 6, 2001

Axonal regrowth following a spinal cord injury is limited and has its peak in intensity immediately after the injury. But, in December 1 Journal of Neuroscience, Jean Coumans and colleagues from Georgetown University Medical Center, Washington, DC, show that delaying treatment with transplants and exogenous neurotrophic factors after spinal cord injury results in more permissive conditions for spinal cord regeneration and functional recovery.Coumans et al. used rats with medullar transection tha

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genome

By | December 5, 2001

Some transposable elements can be beneficial and others may persist in the genomes of sexually reproducing eukaryotes even if they are deleterious. In the December 4 Proceedings of the National Academy of Sciences, Irina Arkhipova and Hilary Morrison report the characterization of retrotransposons in the Giardia lamblia genome (Proc Natl Acad Sci USA 2001, 98:14497-14502).G. lamblia is a protozoan parasite, one of the earliest-branching eukaryotes, and is thought to be asexual. Arkhipova and Mor

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the fight continues

By | December 5, 2001

Despite a lower media profile HIV/AIDS looks set to become the biggest and most far-reaching pandemic in human history.

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The MLL leukemia

By | December 5, 2001

Acute lymphoblastic leukemia with mixed-lineage leukemia gene (MLL) translocations has a particularly poor prognosis, but it is not clear if host-related factors or tumor-intrinsic biological differences are responsible for these poor survival rates. In December 3 on line Nature Genetics, Scott Armstrong and colleagues from Dana-Farber Cancer Institute, Boston, Massachusetts, show that acute leukemia with MLL translocations has a gene expression profile that identifies them as a unique, new type

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Genes repressed by GDNF

By | December 4, 2001

The genes down-regulated by the glial cell-line-derived neurotrophic factor may account for the factor's inhibition of neurite growth.

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Global health and bioterror meeting

By | December 4, 2001

Increased research spending on the agents of bioterrorism could have huge spin offs for the developing world.

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HIV entry and membrane lipid rafts

By | December 4, 2001

Cholesterol lowering drugs could be used to disrupt the cell entry mechanism of many intracellular pathogens.

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Pro-apoptotic influenza protein

By | December 4, 2001

Severe influenza infections can kill, particularly neonates and the elderly, but despite this little is known about the viral proteins involved in pathogenicity. In December Nature Medicine, Weisan Chen and colleagues from the National Institute of Allergy and Infectious Diseases, Bethesda, US, describe a novel influenza A virus mitochondrial protein that induces cell death in host immune cells sent to destroy the influenza virus.Chen et al. searched for alternative peptides encoded by influenza

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