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Caught by the secretory-trap

By | July 4, 2001

The gene-trap strategy can exploit insertional mutagenesis to allow phenotypic screening. In the July issue of Nature Genetics, Mitchell et al. demonstrate the power of gene-trap mutagenesis for genome-wide analysis of the genes involved in mouse development (Nature Genetics 2001, 298:241-24). Their modified 'secretory-trap' vector selects genes that have secretory signal sequences or transmembrane domains. Screening over 500 insertions in mouse embryonic stem (ES) cells identified 187 individua

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The Royal Society Summer Exhibition 2001

By | July 4, 2001

The scientific equivalent of the Royal Academy's Summer Exhibition is underway at Carlton Gardens with over 20 fascinating topics to choose from.

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Deadly fusion

By | July 3, 2001

Translocations in acute megakaryoblastic leukemia result in the fusion of two novel genes.

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Nicotine promotes tumour growth and atherosclerosis

By | July 3, 2001

Treatment for nicotine addiction may be as harmful as smoking, as nicotine seems to promote angiogenesis and tumour formation.

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Degrading mutations

By | July 2, 2001

Mutations in matrix metalloproteases have been detected in inherited osteolytic and arthritic disorder.

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Minor histocompatibility antigen has anti-leukaemic role

By | July 2, 2001

have curative anti-leukaemia activity through a graft-versus-leukaemia effect with no graft-versus-host disease.

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Pollen coat protein gene families

By | July 2, 2001

Clusters of pollen coat protein genes could help define species and prevent non-specific pollination.

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Id and aging

By | June 29, 2001

The Id1 protein inhibits cell senescence by repressing cell-cycle genes.

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Nitric oxide holds the key to firefly glow

By | June 29, 2001

Nitric oxide was once regarded simply as a noxious pollutant. But its ever expanding functional repertoire may now include generation of firefly luminescence.

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TNF signalling in rheumatoid arthritis

By | June 29, 2001

Blocking tumour necrosis factor ligands inhibits both humoral and cellular immune mechanisms in a model of rheumatoid arthritis.

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