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Manipulation of integrin gene activates adult nerve cell regeneration

By | July 11, 2001

Manipulating the integrin gene can enable adult neurons to switch on the molecular mechanisms necessary to allow regeneration.

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Pin-ning down breast cancer

By | July 11, 2001

Pin1, a member of a new family of phosphorylation-specific peptidyl-prolyl isomerases (PPIases), regulates mitosis and neuronal cell death in Alzheimer's disease. In the July 2 EMBO Journal, Wulf et al. propose a mechanism by which Pin1 may contribute to cell proliferation in breast cancer cells (EMBO Journal 2001, 20:3459-3472). They found that Pin1 was overexpressed in breast cancer tissue and correlated with the tumour grade and with the level of cyclin D1 expression. Wulf et al. show that Pi

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Death by endonuclease

By | July 10, 2001

The apoptotic suicide programme involves fragmentation of nucleosomal DNA. In the July 5 Nature, two groups report identification of a mitochondrial nuclease that induces DNA degradation associated with apoptosis in both worms and mammals. Parrish et al. performed a genetic screen in Caenorhabditis elegans to search for suppressors of an activated cell-death protease (CED-3) mutant (Nature 2001, 412:90-94). After screening 3,000 mutagenized haploid genomes, they identified an apoptosis-related g

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mechanism in primary sclerosing cholangitis

By | July 10, 2001

impairs the function of liver derived T lymphocytes and natural killer cells in patients with primary sclerosing cholangitis.

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Circadian clock found in cardiovascular system

By | July 9, 2001

Important progress has been made in understanding how circadian rhythms might be controlled in the cardiovascular system and other organs throughout the body.

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Epigenetically unstable

By | July 9, 2001

In the July 6 Science, Humpherys et al. describe extensive analysis of the expression of imprinted genes in mice derived from cloning by nuclear transfer (NT) (Science 2001, 293:95-97). They examined mRNA levels for several imprinted genes including H19 and Igf2, Peg1/Mest, Mest/Grb10, Peg3 and Snrpn. They found that the expression of imprinted genes varied widely between the placentas of cloned embryos and in the organs of newborn cloned mice. H19 expression was often silenced and Igf2 expressi

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Glyoxylate cycle presents sweet opportunity

By | July 9, 2001

replicating inside macrophages utilise the glyoxylate cycle, presenting a highly selective target for the treatment of systemic candidiasis.

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Control of cell growth

By | July 6, 2001

Control of cell growth and division is essential to prevent aberrant cellular development but the biochemical mechanisms involved are still poorly understood. In July Nature Cell Biology, Duncan Clarke and colleagues from the Scripps Research Institute, La Jolla, California identified the protein securin Pds1p as vital in determining the continuation of cell division.Using the budding yeast as a model, Clarke et al. showed that the coupling of the completion of genome replication with mitosis re

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Stem-cell genomics

By | July 6, 2001

The surprising plasticity and trans-differentiation of transplanted stem-cells suggest that there may be a set of universal stem-cell genes that govern the undifferentiated proliferative state. In the July 3 Proceedings of the National Academy of Sciences, Terskikh et al. report attempts to define a common stem-cell gene profile by comparing hematopoietic and neural stem-cells (Proc Natl Acad Sci USA 2001, 98:7934-7939). They isolated hematopoietic stem cells (HSC) from mouse bone marrow and cre

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Sweet success of immunomodulatory therapy

By | July 6, 2001

expression combined with re-education of newly emerging T cells with self antigens can reverse established autoimmune diabetes in mice.

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