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What is the normal range for gene expression?

By | November 9, 2001

The mouse is being widely used as a model organism in microarray studies, yet little is known about the range of normal physiological variance in gene expression in complex systems in vivo. In the November 6 Proceedings of the National Academy of Sciences, Colin Pritchard and colleagues at the Fred Hutchinson Cancer Research Centre describe a study of normal variation of gene expression levels in mouse tissues (Proc Natl Acad Sci USA 2001, 98:13266-13271).They analysed the expression of over fiv

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Placental profiling

By | November 8, 2001

The extraembryonic lineage is the first to differentiate in mammals following fertilization. In the November 6 Proceedings of the National Academy of Sciences, Myriam Hemberger and colleagues at the Department of Biochemistry and Molecular Biology, University of Calgary, report the use of cDNA subtraction and microarray hybridisation to screen for genes implicated in placentogenesis (Proc Natl Acad Sci USA 2001, 98:13126-13131).They isolated the ectoplacental cone region of mouse conceptuses at

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Liver damage receptor

By | November 7, 2001

Discoidin domain tyrosine kinase receptor 2 is induced in stellate cells during liver injury and perpetuates hepatic damage.

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PTEN profiling

By | November 7, 2001

Microarray analysis using an inducible expression system identifies genes regulated by the PTEN tumour suppressor.

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T cells

By | November 7, 2001

2 T cells are sufficient to control bacterial infections in mice that lack B or T cells.

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Improved anthrax vaccine

By | November 6, 2001

A new anthrax vaccine based on mutant forms of the bacterium's toxic proteins could be on the horizon.

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More genes on the fly Y

By | November 6, 2001

The DrosophilaY chromosome has several features (including its heterochromatic state) that have made mapping and sequencing difficult. The Y chromosome contains genes directly involved with male fertility. In the November 6 Proceedings of the National Academy of Sciences, Antonio Carvalho and colleagues describe a search for more novel Y-linked genes (Proc Natl Acad Sci USA 2001, 98:13225-13230).They used a strategy involving staggered TBLASTN screening of 500,000 proteins against the armU datab

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Light-induced apoptosis

By | November 5, 2001

Exposure to light induces photoreceptor cell death and retinal degeneration in animal models. The absence of some genes (for example, arrestin or rhodopsin kinase) can sensitize the retina to light damage. In the November 6 Proceedings of the National Academy of Sciences, Sangdun Choi and researchers at the California Institute of Technology report the use of gene expression profiling to investigate light-induced apoptosis (Proc Natl Acad Sci USA 2001, 98:13096-13101).They isolated retinal tissu

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New mechanisms in HIV infection

By | November 5, 2001

HIV specific epitopes, human herpesvirus 6, and Nef proteins may be exploited for the production of an effective vaccine against AIDS.

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Sanger Institute looks to the future

By | November 5, 2001

Following the completion of the first draft of the Human Genome the Sanger Institute looks to the post-genomic future.

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