Advertisement

News & Opinion

Covering the life sciences inside and out

Most Recent

Glyoxylate cycle presents sweet opportunity

By | July 9, 2001

replicating inside macrophages utilise the glyoxylate cycle, presenting a highly selective target for the treatment of systemic candidiasis.

0 Comments

Control of cell growth

By | July 6, 2001

Control of cell growth and division is essential to prevent aberrant cellular development but the biochemical mechanisms involved are still poorly understood. In July Nature Cell Biology, Duncan Clarke and colleagues from the Scripps Research Institute, La Jolla, California identified the protein securin Pds1p as vital in determining the continuation of cell division.Using the budding yeast as a model, Clarke et al. showed that the coupling of the completion of genome replication with mitosis re

0 Comments

Stem-cell genomics

By | July 6, 2001

The surprising plasticity and trans-differentiation of transplanted stem-cells suggest that there may be a set of universal stem-cell genes that govern the undifferentiated proliferative state. In the July 3 Proceedings of the National Academy of Sciences, Terskikh et al. report attempts to define a common stem-cell gene profile by comparing hematopoietic and neural stem-cells (Proc Natl Acad Sci USA 2001, 98:7934-7939). They isolated hematopoietic stem cells (HSC) from mouse bone marrow and cre

0 Comments

Sweet success of immunomodulatory therapy

By | July 6, 2001

expression combined with re-education of newly emerging T cells with self antigens can reverse established autoimmune diabetes in mice.

0 Comments

Systems biology research centre to be built in Singapore

By | July 6, 2001

A new research centre is being established in Singapore that will use a multidisciplinary approach to study systems biology.

0 Comments

Hippocampus arrays

By | July 5, 2001

The hippocampus plays a role in the brain's ability to learn and remember. In the Early Edition of the Proceedings of the National Academy of Sciences, Mody et al. report the use of a microarray strategy to define genes involved in the development and function of the mouse hippocampus. They used Affymetrix oligonucleotide arrays to screen for the expression profiles of 11,000 genes in embryonic (E16) or postnatal (P1, P7, P16 and P30) mouse hippocampus tissue. They found that 1,926 genes showed

0 Comments

Caught by the secretory-trap

By | July 4, 2001

The gene-trap strategy can exploit insertional mutagenesis to allow phenotypic screening. In the July issue of Nature Genetics, Mitchell et al. demonstrate the power of gene-trap mutagenesis for genome-wide analysis of the genes involved in mouse development (Nature Genetics 2001, 298:241-24). Their modified 'secretory-trap' vector selects genes that have secretory signal sequences or transmembrane domains. Screening over 500 insertions in mouse embryonic stem (ES) cells identified 187 individua

0 Comments

The Royal Society Summer Exhibition 2001

By | July 4, 2001

The scientific equivalent of the Royal Academy's Summer Exhibition is underway at Carlton Gardens with over 20 fascinating topics to choose from.

0 Comments

Deadly fusion

By | July 3, 2001

Translocations in acute megakaryoblastic leukemia result in the fusion of two novel genes.

0 Comments

Nicotine promotes tumour growth and atherosclerosis

By | July 3, 2001

Treatment for nicotine addiction may be as harmful as smoking, as nicotine seems to promote angiogenesis and tumour formation.

0 Comments

Advertisement

Popular Now

  1. How Fats Influence the Microbiome
  2. Hearing Help
    Features Hearing Help

    For decades, the only remedies for hearing loss were devices such as hearing aids or cochlear implants. Now, the first pharmaceutical treatments may be on the way.
     

  3. Psychology’s Failure to Replicate
  4. The Great Big Clean-Up
    Features The Great Big Clean-Up

    From tossing out cross-contaminated cell lines to flagging genomic misnomers, a push is on to tidy up biomedical research.

Advertisement
BioLegend
BioLegend
Advertisement
Life Technologies