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but will give data away

By | February 1, 2001

and useful technologies to farmers in the developing world.

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Early-onset menopause may have a genetic trigger

By | February 1, 2001

The early onset of menopause and a condition called blepharophimosis, which causes drooping eyelids, seem to be caused by the same genetic defect.

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Irradiation for stent stenosis

By | February 1, 2001

Intracoronary irradiation with iridium-192 reduces the rates of stent restenosis but is associated with a higher rate of late thrombosis and risk of myocardial infarction.

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Signalling lymphangiogenesis

By | February 1, 2001

Vascular endothelial growth factors signal the development of tumour-induced lymph vessel growth and enhance lymphatic metastasis in vivo.A poorly understood characteristic of cancerous tissue is its ability to develop lymphatic tissue by the process of lymphangiogenesis. This is an important consideration because this contributes to the cancer's ability to metastasise through the body. In the February Nature Medicine, three separate research groups provide direct evidence that two recently clon

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Metal hearts undergo trials

By | January 31, 2001

Regulators have given permission for a US biotechnology company to implant metal hearts in a handful of critically ill patients.

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Overuse of drugs for ovarian stimulation questioned

By | January 31, 2001

Fertility experts have called for IVF clinics to limit the use of drugs to stimulate the production of eggs.

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Accelerating new drug development

By | January 30, 2001

US FDA user fees may have accelerated new drug development but a recent survey suggests difficulties in obtaining volunteers for human clinical trials still slow progress.

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Impotent B cells

By | January 30, 2001

In chronic lymphocytic leukaemia the non-malignant B cells do not mature to produce IgG and IgA because of an interaction with CD30+ T cells.In patients with chronic lymphocytic leukaemia antibody production by B cells is severely impaired and this is associated with increased susceptibility to bacterial infections. The mechanisms behind the immune defects have remained elusive. In the February issue of Nature Immunology, researchers from Cornell University, New York, show how leukaemia cells in

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Stimulatory sonic hedgehog

By | January 30, 2001

Current bone marrow transplant treatment of cancer patients does not include agents to amplify the number of repopulating stem cells. A step closer to developing an appropriate drug has been made by Mickie Bhatia and colleagues from the John P. Robarts Research Institute, London, Canada who report in the February issue of Nature Immunology how the sonic hedgehog protein is involved in the regulation of the human stem cell pool.Their research indicates that the cytokine-induced proliferation of p

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Transcriptional targets

By | January 30, 2001

In the January 25 Nature, Iyer et al. describe an elegant technique to identify transcriptional target genes throughout the genome (Nature 2001, 409:533-538). They combined chromatin immunoprecipitation (ChIP) with microarray analysis (DNA chips) to probe individual protein-genome interactions. The technique involved cross-linking, immunoprecipitation, PCR amplification and fluorescent labeling, followed by hybridization to microarrarys containing genomic DNA. They searched the yeast genome fo

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