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Fibrinogen, stroke and obstructive sleep apnea

By | December 14, 2000

Patients with ischemic stroke and obstructive sleep apnea (OSA) have elevated fibrinogen levels which correlate positively with apnea severity.

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Media campaign reduces smoking deaths

By | December 14, 2000

The Golden State offers evidence that funding media campaigns reduces smoking-related deaths.

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Plant sequence completed

By | December 14, 2000

gives us an idea of how plants function.

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Go to the end of the Ku

By | December 13, 2000

Telomeres are specialized structures at the ends of chromosomes that prevent fusion events and promote chromosomal end replication. Telomeres are maintained by the regulation of telomerase activity and their capping by telomeric proteins. In the November Genes and Development, Hsu et al. show that the DNA repair protein Ku plays a role in telomere capping (Gene Dev 2000, 14:2807-2812). Hsu et al. used surface plasma resonance and co-immunoprecipitation to demonstrate that Ku forms a high-affini

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Rax2 marks the spot

By | December 13, 2000

Haploid yeast cells bud next to the site of the previous division (axial pattern), but diploid yeast cells bud from their poles (bipolar pattern). In the 8 December Science, Chen et al. propose that the Rax2 protein marks the cortex to provide a landmark for bipolar budding (Science 2000, 290:1975-1978). Rax2 is an integral membrane protein, discovered following a hunt for mutants defective in bipolar budding. Late in the cell cycle, Rax2 protein localizes to rings associated with division sites

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Rock, paper, scissors, lizard

By | December 13, 2000

Male side-blotched lizards (Uta stansburiana) have three heritable throat colors, associated with three divergent mating strategies. In the 19 December Proceedings of the National Academy of Sciences, Zamudio and Sinervo find that these alternative mating strategies can stably coexist because, as in a game of rock, paper, scissors, each strategy has strengths over one other, and weaknesses in the face of the third (Proc Natl Acad Sci USA 2000, published online ahead of print). The strategy of bl

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Cannabis could influence fertility

By | December 12, 2000

Cannabis smoking could disrupt the natural cannabinoid signalling system responsible for regulating sperm structure, vigour and fertility.

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Variant of the RANTES cytokine associated with asthma

By | December 12, 2000

A polymorphism within the promoter region of the RANTES chemokine gene is associated with an increased risk of asthma and atopy.

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Disturbed cerebral venous flow can cause amnesia

By | December 11, 2000

Retrograde venous flows in the internal jugular veins during strain are associated with transient global amnesia (TGA), Sander et al report in the 9 December Lancet (Lancet 2000 356:1983-1984). The retrograde flow leads to venous ischaemia and metabolic alterations to bilateral diencephalic or hipocampal structures.Dr Sander and colleagues from the University of Munich examined the blood flow of internal jugular veins in 21 patients with TGA and 21 matched controls. Using duplex ultrasonography

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DNA repair within nucleosomes

By | December 11, 2000

DNA lesions are repaired by a cut-and-remove process called nucleotide excision repair. An in vitro biochemically defined system has been developed in which six repair factors are sufficient to excise damage from naked DNA. In the December Molecular and Cellular Biology, Hara et al. use this system to examine the effect of DNA organization into nucleosome structures on the DNA repair process (Mol Cell Biol 2000, 20:9173-9181). A nucleosome structure was assembled by mixing human histone protein

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