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Designer leaves

By | February 26, 2002

The shape of a leaf can be controlled by modulation of cell division on the flanks of young leaf primordia.

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Mouse mutagenesis

By | February 26, 2002

Large-scale mutagenesis projects using the chemical mutagen ethylnitrosurea (ENU) are being developed to help with the functional annotation of the mouse genome. In an Advanced Online Publication in Nature Genetics, Emma Coghill and colleagues describe a gene-driven approach to find mutant mice (Nat Genet 2002, DOI:10.1038/ng847).Coghill et al. screened over 2,000 samples contained within an archive of DNA and sperm from the UK ENU mutagenesis program. They screened the archives for four genes u

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Histone modification in heterochromatin

By | February 25, 2002

The spatial organization of pericentric chromatin is established by histone acetylation and methylation, and involves an RNA component.

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Kidneys shaped

By | February 25, 2002

Polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells.

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Resistance to antiangiogenic cancer therapy

By | February 25, 2002

Angiogenesis inhibitors are potent anticancer drugs thought to lack acquired drug resistance problems because they target the normal endothelial cells of the tumor vasculature. But, in February 22 Science, Joanne Yu and colleagues from University of Toronto, Canada, show that p53 loss in tumor cells confers a resistance to hypoxia that might reduce the efficacy of antiangiogenic therapy.Yu et al. compared the response to antiangiogenetic therapy of tumors derived from paired isogenic p53-/- and

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Copy cat

By | February 22, 2002

A whole menagerie of animals (including sheep, mice, cattle, goats and pigs) have been cloned by transfer of nuclear genetic material into an enucleated cell. Now, in an Advanced Online Publication from Nature,Taeyoung Shin and colleagues demonstrate that cats (Felis domesticus) can be cloned too (Nature 2002, DOI: 10.1038/nature723).Shin et al. isolated fibroblasts from the oral mucosa of an adult male cat or primary cumulus cell cultures and fused them with enucleated cat ova; they then implan

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Public consultation needed on xenotransplants

By | February 22, 2002

A session on xenotransplantation at the AAAS this week highlighted the need for urgent public consultation.

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Saving stressed sperm

By | February 22, 2002

Heme oxygenase-1 derived from Leydig cells in the testis regulates apoptosis of premeiotic spermatocytes in response to stress.

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Taming Toxoplasma

By | February 22, 2002

pyrimidine biosynthesis pathway.

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Interferon cells revealed

By | February 21, 2002

by a specific subset of dendritic cells in the absence of feedback signaling.

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