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Bacterial offender in parasitic infection

By | March 13, 2002

bacteria in filarial parasites have a major role in the corneal pathology of river blindness.

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Overcoming immune ignorance

By | March 13, 2002

CD137 signaling induces a CTL response leading to the regression of established tumors.

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Take your PIC

By | March 13, 2002

Analysis of differentiation-dependent transcription reveals that the pre-initiation complex (PIC) can assemble before chromatin remodeling.

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Biotech blues

By | March 12, 2002

The departure for Singapore of 'Dolly scientist' Alan Colman has raised questions about the viability of British biotechnology.

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Drought resistance gene

By | March 12, 2002

Under drought conditions organisms including nematodes, can enter a state of suspended animation known as anhydrobiosis. This process enables nematodes to survive until rehydration but the precise molecular control mechanisms remain unclear. In March 7 Nature, John Browne and colleagues from National University of Ireland Maynooth, describe a plant desiccation gene that is also found in a nematode.Browne et al. identified a strongly induced 675 base transcript in the anhydrobiotic nematode Aphel

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Musical protection

By | March 12, 2002

There has been much debate about whether DNA sequences may, or indeed should, be patented. This issue has prevented the release and dispersal of much genomic data by commercial genomics companies. In the March issue of Nature Biotechnology, Willem Stemmer of Maxygen Inc. in California, offers a harmonious solution for the sharing of DNA sequences while maintaining intellectual property (IP) protection (Nat Biotechnol 2002, 20:217).While the patentability of DNA is in question, music and original

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Proteasome inhibitors to treat psoriasis

By | March 12, 2002

Psoriasis is a chronic skin inflammation that may involve bacterial superantigens, but the inflammatory mechanisms and T cell responses remain poorly understood. In March 1 Journal of Clinical Investigation Thomas Zollner and colleagues from JW Goethe University of Frankfurt, Germany, show that proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model.Zollner et al. used human psoriatic skin tissue engrafted onto mice and observed that

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Antisense spuds

By | March 11, 2002

Unmodified starches present a problem to the frozen food industry as they tend to result in poor texture upon cycles of freeze-thawing. In March Nature Biotechnology, Stephen Jobling and colleagues describe a genetic solution to generating freeze-thaw-stable starch (Nat Biotechnol 2002, 20:295-299).Jobling et al. created potato plants with reduced levels of the three starch synthase genes using triple antisense technology. The authors showed that the there was an efficient downregulation of the

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-GalCer

By | March 8, 2002

-galactosylceramide can boost vaccine induced cellular immunity.

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L'Oreal and UNESCO recognize exceptional women in science

By | March 8, 2002

L'Oreal and UNESCO have honored 16 women for their outstanding contributions to science.

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