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The sweet taste of success

By | August 16, 2001

The perception of sweet taste has fascinated philosophers, cooks and scientists for centuries, but the molecular mechanisms involved in taste perception remained elusive. In August 10 Cell, Greg Nelson and colleagues from the University of California at San Diego, La Jolla, US dissect the signal detection of taste and report the characterization of new mammalian sweet receptors present on the cells of the tongue and palate.Nelson et al. developed transgenic rescue experiments to prove that the S

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A pathway to therapeutic destruction

By | August 15, 2001

via caspase-1dependent mechanisms.

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Hope for CJD sufferers

By | August 15, 2001

Drugs already licensed for the treatment of malaria and schizophrenia could be used to treat vCJD.

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Transcriptional switch

By | August 15, 2001

Ordered acetylation of the HMGI(Y) protein controls enhanceosome stability and switches on gene expression.

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Exploiting the autoimmune response

By | August 14, 2001

Conjugation of a self-antigen to papillomavirus-like particles elicit high titers of autoantibodies that can be used to treat arthritis and other diseases.

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Heterochromatin boundaries

By | August 14, 2001

Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10 Science, Noma et al. define the boundaries of the heterochromatin domain at the mating-type locus (mat) in fission yeast (Science 2001, 293:1150-1155).They used chromatin immunoprecipitation (ChIP) and PCR analysis to scan the entire mat region (about 47 kilobases). Methylation of lysine 9 of histone H3 and the Swi6 protein were both enriched in a 20kb interval that contains the mat2/3 s

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Photobiology reduces the need for biopsies in bladder cancer

By | August 14, 2001

The photoactive protein protoporphyrin IX is more abundant in cancer cells, enabling ready identification of certain tumours.

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Adult stem cell hope for kidney patients

By | August 13, 2001

In addition to differentiating into, for example, liver and nerve cells, adult stem cells could develop into kidney cells.

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Compromise by Bush reinforces stem cell research ambiguity

By | August 13, 2001

President Bush surprised the US last week by announcing a policy on embryonic stem cells research that will satisfy neither proponents or opponents of such work.

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DNA/DNA microarrays

By | August 13, 2001

Microbial comparative genomics provides insights into gene function, bacterial speciation and evolutionary relationships. In the August 14 Proceedings of the National Academy of Sciences, Murray et al. describe an approach to explore genome diversity and relatedness in the absence of complete sequence information (Proc Natl Acad Sci USA 2001, 98:9853-9858).They used sequence information from the Shewanella oneidensis strain MR-1 to construct DNA microarrays containing over 100 full-length open r

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