In mice, cancer cells genetically modified to express an anticancer cytokine home to tumors and can reduce their growth.
August 14, 2001|
Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10 Science, Noma et al. define the boundaries of the heterochromatin domain at the mating-type locus (mat) in fission yeast (Science 2001, 293:1150-1155).They used chromatin immunoprecipitation (ChIP) and PCR analysis to scan the entire mat region (about 47 kilobases). Methylation of lysine 9 of histone H3 and the Swi6 protein were both enriched in a 20kb interval that contains the mat2/3 s