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Heterochromatin boundaries

By | August 14, 2001

Chromosomes are composed of functionally distinct domains separated by chromatin boundaries. In the August 10 Science, Noma et al. define the boundaries of the heterochromatin domain at the mating-type locus (mat) in fission yeast (Science 2001, 293:1150-1155).They used chromatin immunoprecipitation (ChIP) and PCR analysis to scan the entire mat region (about 47 kilobases). Methylation of lysine 9 of histone H3 and the Swi6 protein were both enriched in a 20kb interval that contains the mat2/3 s

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Photobiology reduces the need for biopsies in bladder cancer

By | August 14, 2001

The photoactive protein protoporphyrin IX is more abundant in cancer cells, enabling ready identification of certain tumours.

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Adult stem cell hope for kidney patients

By | August 13, 2001

In addition to differentiating into, for example, liver and nerve cells, adult stem cells could develop into kidney cells.

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Compromise by Bush reinforces stem cell research ambiguity

By | August 13, 2001

President Bush surprised the US last week by announcing a policy on embryonic stem cells research that will satisfy neither proponents or opponents of such work.

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DNA/DNA microarrays

By | August 13, 2001

Microbial comparative genomics provides insights into gene function, bacterial speciation and evolutionary relationships. In the August 14 Proceedings of the National Academy of Sciences, Murray et al. describe an approach to explore genome diversity and relatedness in the absence of complete sequence information (Proc Natl Acad Sci USA 2001, 98:9853-9858).They used sequence information from the Shewanella oneidensis strain MR-1 to construct DNA microarrays containing over 100 full-length open r

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A new mechanism for hypertension

By | August 10, 2001

A newly identified metabolic pathway controlling blood pressure in humans could help design drugs to treat hypertension.

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Argonaute2

By | August 10, 2001

Argonaute2, a component of the nuclease complex that carries out gene-silencing during RNAi, has been biochemically purified.

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BSE origins remain obscure, but the epidemic is clearer

By | August 10, 2001

The long awaited Horn report on the BSE epidemic throws up as many questions as it answers.

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Space adds new dimension to cancer research

By | August 10, 2001

Culturing cells in the reduced gravity conditions of the International Space Station could help refine cancer treatment regimes.

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Sporozoite transcriptome

By | August 9, 2001

The protozoan parasite Plasmodium causes malaria, the most serious parasitic disease in humans. The identification of proteins expressed at the infectious sporozoite stage is important for the selection of potential vaccine candidates. In the August 14 Proceedings of the National Academy of Sciences, Stefan Kappe and colleagues from the New York University School of Medicine describe attempts to characterize the sporozoite transcriptome (Proc Natl Acad Sci USA 2001, 98:9895-9900).They construct

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