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Macrophage inflammatory protein inhibits HIV replication

By | May 21, 2001

has only weak antiviral activity.

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New malaria center for Johns Hopkins

By | May 21, 2001

Malaria research has been underfunded for decades. Now, a $100 million donation to Johns Hopkins University should allow much-needed progress on vaccines.

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Prohibitin genotyping as breast cancer indicator

By | May 21, 2001

The 3' untranslated region of the prohibitin gene encodes an RNA molecule that arrests cell proliferation when injected into breast cancer cell lines. A single point mutation in this region creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. In May 19 Lancet, Eldon Jupe and colleagues from Oklahoma Medical Research Foundation, Oklahoma City present evidence that women carrying the prohibitin T allele have increased susceptibility to breast

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Bugs in the genome

By | May 18, 2001

Comparative proteome analysis identifies just 40 genes that are candidates for lateral transfer from bacteria to vertebrates.

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Emotional stimuli

By | May 18, 2001

The amygdala enhances our perception of stimuli that have emotional significance.

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No link between mumps and inflammatory bowel disease

By | May 18, 2001

Mumps virus DNA could not be detected in intestinal specimens or peripheral blood lymphocytes from patients with inflammatory bowel disease.

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Nottingham's smoking gun

By | May 18, 2001

Editor from his post at Nottingham University inprotest at tobacco industry funding has ignited a fierce debate over ethicsand impartiality in medical research.

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Horizontal transfer of tumorigenesis

By | May 17, 2001

Apoptotic bodies are rapidly cleared in the body by phagocytosis. In the May 22 Proceedings of the National Academy of Sciences, Bergsmedh et al. provide evidence that the uptake of apoptotic bodies can deliver oncogenes to the phagocytotic host cell (Proc Natl Acad Sci USA 2001, 98:6407-6411). They could detect the horizontal transfer of H-rasV12 or c-myc oncogenes from dying, transformed rat fibroblast cells to recipient mouse fibroblasts. DNA transfer was detected by PCR analysis and fluoresc

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Mining the mouse

By | May 17, 2001

Despite the announcement of draft mouse genome sequences, it will be some time before a credible mouse genome is established.

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Obesity weighs in as major cancer cause

By | May 17, 2001

Obesity is the single most important cause of cancer among non-smokers, concludes a major review of research carried out over the last 50 years. But the nature of the relationship remains unclear and the benefits of dieting are unknown.In 17 May Nature Julian Peto from the Institute of Cancer Research, Surrey points out that tobacco remains the biggest health risk by far, causing cancer in 60% of smokers. Other causes include alcohol, sunlight and air pollution, each responsible for about 1% of

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