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France acts on threat of BSE transmission by blood

By | January 23, 2001

The French blood transfusion authorities are banning donors who might have become exposed to BSE in the UK.

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Nerve regeneration no longer a Nogo area

By | January 23, 2001

Identification of a mechanism for blocking an inhibitor of axonal regrowth following injury could enable better recovery from CNS injury.

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Prothrombic effects of smoking may be directly due to nicotine

By | January 23, 2001

Smoking is associated with increased platelet-dependent thrombin generation, suggesting that smokers are in a chronic prothrombic state.

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Therapeutic cloning of human embryos to go ahead

By | January 23, 2001

Members of the UK's House of Lords voted last night in favour of allowing the cloning of human embryos for stem cell research.

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'I' is to the right

By | January 22, 2001

After damage or anaesthetisation of the right brain hemisphere, some people can suffer from misidentification of their own extremities (a condition known as asomatopagnosia). Researchers from Harvard Medical School believe they now have the data to explain why this happens.Julian Paul Keenan and colleagues studied patients who were having their brain hemispheres individually anaesthetised to investigate their epilepsy. During anaesthesia, the patients were shown pictures of faces generated by mo

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Genetic screening for FH

By | January 22, 2001

Genetic screening is the best available diagnosis option for relatives of patients with familial hypercholesterolaemia.

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Isolating the cow genome

By | January 22, 2001

Inbreeding is thought to cause reduced genetic variation and diminished viability. In the January 18 Nature, Visscher et al. studied the genome of a viable herd of cows, Chillingham cattle (Bos taurus), that have lived as an isolated inbred herd for over 300 years in the north of England (Nature 2001, 409:303). Visscher et al. analyzed 13 of the Chillingham animals (the breed totals just 49 animals) and scored for 25 polymorphic microsatellite markers. They report that the herd is remarkably ho

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New patent strategy succeeds - for now

By | January 22, 2001

Bristol-Myers Squibb's novel patent strategy could prove effective in protecting its marketing exclusivity for the blockbuster anxiety drug BuSpar.

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Nucleosome remodelling takes its Toll

By | January 22, 2001

Mammalian Toll-like receptors (TLRs) bind to bacterial lipopolysaccharides (LPS) leading to the induction of several cytokine genes that are essential for the inflammatory response. Activation of the Rel proteins is thought to be critical for TLR-induced transcriptional induction. As described in the January Nature Immunology, Weinmann et al. have used TLR4 mutant mice to show that TLR signaling is required for nucleosome remodeling at the interleukin 12 p40 promoter upon induction with LPS (N

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Tales of PU

By | January 22, 2001

Members of the PU.1/Spi family of Ets-type transcription factors play key roles in mammalian hematopoiesis and lymphoid development. Lymphocytes are found in jawed vertebrates, including cartilaginous fish, but not in jawless vertebrates or invertebrates. In the January 16 Proceedings of the National Academy of Science Anderson et al. identified three PU.1 members in the cartilaginous fish Raja eglanteria (skate)(Proc Natl Acad Sci USA 2001, 98:553-558). Phylogenetic analysis established that

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