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Premature death

By | February 14, 2002

Although mice cloned by somatic-cell nuclear transfer appear relatively normal, the long-term consequences of cloning are now becoming apparent. In an Advanced Online Publication from Nature Genetics, Ogonuki et al. report that cloned mice die earlier than normal animals (Nat Gen 2002, DOI:10.1038/ng841).They followed 12 male mice cloned from immature Sertoli cells, together with genetically matched controls and mice generated by spermatid injection. The cloned mice grew normally, but they began

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Suicide gene therapy for colon cancer

By | February 14, 2002

Injection of suicide gene modified tumor cells induces a systemic antitumor response in a rat model of metastatic colon carcinoma.

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Building brand new kidneys

By | February 13, 2002

Advanced Cell Technology has sparked yet more controversy with its claim to have grown kidney-like organs.

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Cloning from lymphocytes

By | February 13, 2002

Cloning animals from nuclei that are genetically marked by terminal differentiation remains inefficient, with most clones dying during gestation. In February 10 online Nature, Konrad Hochedlinger and Rudolf Jaenisch from Massachusetts Institute of Technology, Cambridge, USA, show that monoclonal mice can be generated by nuclear transfer from mature B and T donor cells. Hochedlinger & Jaenisch transferred nuclei from peripheral lymph node cells of mice into enucleate oocytes. From the resulti

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Time control

By | February 13, 2002

The mammalian circadian clock is based on autonomous rhythmic expression of several clock genes in the pituitary gland, but how these signals are disseminated into the periphery remains unclear. In February 11 online Nature Neuroscience, Charlotte von Gall and colleagues from Johann Wolfgang Goethe-University, Frankfurt, Germany, show that rhythmic gene expression in the pituitary is linked with the release of the neurohormones melatonin and prolactin.von Gall et al. used rodent pituitary cells

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Vasculature mapping

By | February 13, 2002

A few years ago Renata Pasqualini and Erkki Ruoslahti developed an in vivo selection method to identify peptides that target specific vascular beds following intravenous administration of random peptide phage-display libraries in mice. In the February issue of Nature Medicine, Pasqualini's group at the MD Anderson Cancer Center in Texas report the application of 'in vivo phage display' to characterize the human vasculature (Nat Med 2002, 8:121-127).They injected a large-scale, random peptide lib

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Doing the genome shuffle

By | February 12, 2002

DNA shuffling mimics an accelerated evolutionary process that selects for improved individuals. DNA shuffling allows for recombination between multiple parents at each generation, resulting in 'complex progeny' and faster selection. In the February 7 Nature Ying-Xin Zhang and colleagues at Maxygen in California describe using a whole-genome shuffling approach to derive new bacterial strains (Nature 2002, 415:644-646).They chose to shuffle Streptomyces, used to produce commercial antibiotics. Zha

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Early detection of ovarian cancer with proteomic patterns

By | February 12, 2002

Computer-assisted detection of proteomic patterns identifies types of ovarian cancer and could help screen high-risk populations.

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'Off-switch' for systemic inflammation

By | February 11, 2002

, a transcription factor activated by the IL-6 family of cytokines, has a critical role in the control of systemic inflammation.

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Cool sensations

By | February 11, 2002

Cold sensation has a specific receptor but can also be produced by coordinated action of several different ion channels.

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