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April 26, 2002|
There is some evidence that schizophrenia may have a genetic contribution, and susceptibility loci have been reported on chromosome 1q. In the April 26 Science Douglas Levinson and colleagues report their failure to confirm this genetic linkage in a larger sample (Science 2002, 296:739-741).They genotyped 16 microsatellite markers in 779 informative pedigrees containing almost a thousand affected sibling pairs, and an additional 1918 schizophrenic individuals. Statistical analysis of this large