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Breast cancer mouse

By | May 24, 2001

In mice, null mutations of the breast cancer susceptibility gene Brca1 result in embryonic lethality. In the May 15 Genes & Development, Ludwig et al. describe the generation of a mutant mouse that expresses a truncated Brca1 protein that mimics mutations found in human breast cancer patients (Genes & Development 2001, 15:1188-1193). They used a two-step 'knock-in' targeting strategy to insert a stop codon in Brca1 exon 11. The genetic background of the mice determined the extent of embr

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Association of viral genomic DNA with heart graft loss

By | May 23, 2001

Identification of viral DNA in the myocardium of paediatric transplant recipients is predictive of adverse clinical events, including coronary vasculopathy.

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Gene found that could increase susceptibility to autism

By | May 23, 2001

A gene has been identified that could influence susceptibility to autism in humans.

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in chicks

By | May 23, 2001

Overexpression of the c-myc oncogene induces multistaged neoplastic progression leading to B-cell lymphomas in the bursa of Fabricius. In the May 22 Proceedings of the National Academy of Sciences, Neiman et al. describe the use of microarray analysis to define the genetic networks important for myc-induced lymphomagenesis (Proc Natl Acad Sci USA 2001, 98:6378-6383). The authors created a customized cDNA microarray containing over 2,200 genes associated with the immune system - details can be fo

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Cytokine secretion linked to emotional and cognitive disturbances

By | May 22, 2001

Positive correlations were found between cytokine secretion and endotoxin-induced anxiety, depressed mood and decreases in memory performance.

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Gene linked to Crohn's disease

By | May 22, 2001

Two independent research teams in Europe and the US have identified a defective gene that increases susceptibility to Crohn's disease.

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Mannose binding lectin gene influences severity of liver disease

By | May 22, 2001

An independent genetic factor, the mannose binding lectin gene influences liver disease severity in cystic fibrosis patients.

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Painting the fourth

By | May 22, 2001

Chromosome 4 of Drosophila melanogaster is an atypical autosome, exhibiting several features characteristic of the X chromosome. In the May 22 Proceedings of the National Academy of Sciences, Larsson et al. report the molecular cloning of Painting of fourth (Pof), which encodes a protein that specifically paints chromosome 4 (Proc Natl Acad Sci USA 2001, 98:6273-6278). The POF protein sequence contains a putative RNA-binding domain. POF protein decorates chromosome 4 by spreading out from an ini

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Lively lipids

By | May 21, 2001

In the May 18 Science, Farber et al. report the use of fluorescently quenched phospholipid substrates to screen for genes affecting lipid metabolism in living zebrafish larvae (Science 2001, 292:1385-1388). The lipids were swallowed by the larvae and cleaved by lipases in the intestine before the fluorescent metabolites were transported to the liver and gall bladder. The assay demonstrated lipid metabolism defects in zebrafish mutants that have abnormal digestive organ morphology, as well as the

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Macrophage inflammatory protein inhibits HIV replication

By | May 21, 2001

has only weak antiviral activity.

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