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Schizophrenia surprise

By | April 26, 2002

There is some evidence that schizophrenia may have a genetic contribution, and susceptibility loci have been reported on chromosome 1q. In the April 26 Science Douglas Levinson and colleagues report their failure to confirm this genetic linkage in a larger sample (Science 2002, 296:739-741).They genotyped 16 microsatellite markers in 779 informative pedigrees containing almost a thousand affected sibling pairs, and an additional 1918 schizophrenic individuals. Statistical analysis of this large

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cancer link dismissed

By | April 25, 2002

There is no correlation between the risk of acoustic neuroma and mobile phone use.

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Genes for hypertrophic cardiomyopathy identified

By | April 25, 2002

gene may cause hypertrophic cardiomyopathy by disrupting expression of two cardiac contractile proteins.

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Mammalian ancestors

By | April 25, 2002

A dormouse-like fossil is the earliest member of a group that eventually led to the placental mammals.

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Tick tock

By | April 25, 2002

Mammalian peripheral tissues have circadian clocks that keep time by generating daily rhythms of transcription. In an Advanced Online Publication in Nature, Kai-Florian Storch and colleagues at Harvard Medical School, report a comparative analysis of the circadian variation in gene expression in mouse liver and heart (Nature 2002, DOI 10.1038/nature744).Storch et al. used oligonucleotide microarrays to follow changes in the expression of over 12,000 genes over a 24 hour period. They applied a fi

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Hague meeting targets biopiracy

By | April 24, 2002

The UN Biodiversity Congress last week produced guidelines to curb biopiracy but they don't satisfy ecoactivists.

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Keeping a CHEK on breast cancer

By | April 24, 2002

Mutations in the tumor suppressor genes BRCA1 and BRCA2 account for a small percentage of breast cancer cases. In 22 April Advanced Online Publication from Nature Genetics, Meijers-Heijboer and colleagues from the CHEK-Breast Cancer Consortium report the identification of a mutation in the CHEK2 gene that increases the risk of breast cancer in both women and men (Nat Genet 2002, DOI: 10.1038/ng879).They performed a genome-wide linkage search in a family with BRCA-independent breast cancer and id

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Notch determines B cell fate

By | April 24, 2002

RBP-J signaling is involved in cell fate determination of marginal zone B cells in the spleen.

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Support for use of animals in research

By | April 24, 2002

The UK government has set out in full for the first time its policy on the use of animals in medical research.

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2002 Gairdner International Awards announced

By | April 23, 2002

The 2002 awards recognize the impact of genomics, proteomics and bioinformatics.

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