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Biomedical researchers in the UK breathed a sigh of relief this week as a new law lifted the threat of the data protection regulations. But can research without patient consent continue as before?

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Corneal healing through apoptosis

By | May 16, 2001

The Arthus type allergic reaction in the cornea is characterised by inflammatory cell infiltration and marked neovascularisation. This gradually disappears during the healing stages through mechanisms that are not yet elucidated but which are essential to preserve vision. In the May British Journal of Ophtalomology, Noriko Ozaki and colleagues from the Nippon Medical School, Tokyo show that regression of the Arthus reaction in the cornea occurs via apoptosis.Ozaki et al injected bovine serum alb

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Reactivating liver genes

By | May 16, 2001

functions in the developmental control of methylation and chromatin remodelling.

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A human urate transporter data sheet

By | May 15, 2001

High serum levels of uric acid are associated with an increased risk of developing gout, hypertension, cardiovascular disease and renal failure. Urate is produced as a result of purine degradation and as yet little is known about the pathway for urate efflux from cells. In the May Journal of Clinical Investigation Michael Lipkowitz and colleagues from the Mount Sinai School of Medicine, New York provide data on the human urate transporter galectin 9.Lipkowitz et al show that a recombinant protei

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Genetic susceptibility to prion diseases

By | May 15, 2001

Genetic loci other than the prion protein gene have a major effect on prion disease incubation time in mice; multiple quantitative trait loci on three chromosomes can explain 82% of the variance.

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Twelve thousand Asian men

By | May 15, 2001

The 'Out-of-Africa' hypothesis posits that modern humans derive from an African originator population, that spread outward replacing local populations approximately 100,000 years ago. In the May 11 Science, Ke et al. report the use of Y chromosome polymorphism analysis to test the origins of modern Asian man (Science 2001, 292:1151-1153). They looked at 12,127 men from 163 different populations across Southeast and Central Asia and typed three Y chromosome biallelic markers (YAP, M89 and M130).

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2001 Royal Society Fellows

By | May 14, 2001

LONDON The UK Royal Society today announced the election of 42 Fellows, 6 Foreign Members and 1 Honorary Fellow for 2001. Those elected to the distinguished organization today include: Richard Dawkins for his work on evolution and for raising the public understanding of science; molecular plant virologist David Baulcombe; internet pioneer Timothy Berners-Lee; the developmental geneticist Robin Lovell-Badge; oncologist Bruce Ponder and Sheila Sherlock for her work on the pathology of liver failur

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Inhibition of matrix metalloproteinases by tissue factor pathway inhibitor-2

By | May 14, 2001

Tissue factor pathway inhibitor-2 reduces interstitial collagenase degradation of triple-helical collagen and may be of use in the treatment of atherosclerosis.

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Linkage disequilibrium

By | May 14, 2001

Linkage disequilibrium (LD) refers to the correlation among neighboring alleles, reflecting common haplotype ancestry. In the May 10 Nature, Reich et al. describe a systematic, genome-wide analysis of LD within human populations (Nature 2001, 411:199-204). They analyzed 19 random chromosomal regions, each of which centers around a core SNP (single length polymorphism) in the coding region of a gene. Extensive sequencing of 44 individuals from Utah identified 272 'high frequency' SNPs at 0-160 ki

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Mutation in Cd36 gene protects from malaria

By | May 14, 2001

Erythrocytes infected with Plasmodium falciparum adhere to host CD36 receptors expressed on endothelial cells, platelets and leucocytes. This process is thought to benefit parasite survival in malaria. In the 12 May Lancet, Arnab Pain and colleagues from the Institute of Molecular Medicine in Oxford, UK report a mutation in the Cd36 gene that is associated with protection from severe malaria.Pain et al sequenced DNA from two Afro-Americans who did not express CD36 on their platelets and identifi

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