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The Celera paper: sequencing by random shotgun cloning

By | February 13, 2001

In the February 16 Science, Venter et al. announce the sequencing of the euchromatic portion of the human genome by a whole-genome shotgun sequencing approach (Science 2001, 291:1304-1350). The sequencing achievement was accomplished by Celera Genomics in nine months in a factory-scale project involving 300 automatic squencing machines (ABI PRISM 3700) producing 175,000 sequence-reads per day. The company generated 14.8 gigabases (Gb) of DNA sequence and combined data with the public GenBank) da

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The Human Genome Consortium paper: sequencing by collaborative mapping

By | February 13, 2001

In the February 15 Nature, the International Human Genome Sequencing Consortium announces the completion of the first draft of the sequence of the human genome. The publication is the achievement of the decade-long Human Genome Project based on open international collaboration (involving 20 groups) and rapid, unrestricted data release (via GenBank). The draft sequence covers 94% of the genome, which is estimated to be about 3.2 Gigabases (Gb), 25 times the size of any previously sequenced genome

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Endotoxin role in airway disease

By | February 12, 2001

Inhalation of corn dust extract results in the development of chronic airway disease in mice sensitive to endotoxin but not in mice that are genetically hyporesponsive to endotoxi.

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let the debate begin

By | February 12, 2001

of papers laying bare the human genome brings the first chapter of genomic research towards its completion. Once the happy handshakes are over the real business will start. It'll be up to policy makers to grapple with the implications and scientists to see whether all the effort was worthwhile.

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Mechanism of heat stroke

By | February 12, 2001

Hyperthermia stimulates xanthine oxidase production of reactive oxygen species that limit heat tolerance by promoting circulatory and intestinal barrier dysfunction..

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MMR is not linked with autism

By | February 12, 2001

A new study concludes that MMR is not linked to autism because the incidence of autism continued to increase among boys from 1988 to 1993 while the MMR vaccine coverage in the UK was virtually constant.

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Complete mitochondrial genome sequences of two extinct birds

By | February 9, 2001

The first complete mitochondrial genome sequence of an extinct species is reported.

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An encyclopaedia of mouse genes

By | February 8, 2001

An international consortium of scientists aiming to sequence every transcript encoded by the mouse genome has analysed 21,076 so far.Estimates of the number of genes in the mammalian genome range from 30,000 to 200,000. The problem is one of identifying which of the sequences in the billions of base pairs that make up the genome actually code for protein. Instead of sequencing all 109 bp in the mouse genome, an international consortium of scientists has been sequencing a large bank of cDNAs prep

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Speciation induced by a bacterial symbiont?

By | February 8, 2001

The cytoplasmic symbiotic bacteria Wolbachia could induce host speciation in insects.

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Nuclear reprogramming in cloned cows

By | February 7, 2001

Telomere length shortens upon culture of fibroblast cells in vitro. But what happens to chromosomal ends and telomerase activity when nuclei from these aged cells are used to clone animals by somatic nuclear transfer? In the January 30 Proceedings of the National Academy of Science Betts et al. report on telomeres and telomerase activity in early and late-passage donor fibroblasts and recipient cloned bovine embryos (Proc Natl Acad Sci USA 2001, 98:1077-1082). Despite the reduction in telomere l

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Mettler Toledo
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