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Tick tock

By | April 25, 2002

Mammalian peripheral tissues have circadian clocks that keep time by generating daily rhythms of transcription. In an Advanced Online Publication in Nature, Kai-Florian Storch and colleagues at Harvard Medical School, report a comparative analysis of the circadian variation in gene expression in mouse liver and heart (Nature 2002, DOI 10.1038/nature744).Storch et al. used oligonucleotide microarrays to follow changes in the expression of over 12,000 genes over a 24 hour period. They applied a fi

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Hague meeting targets biopiracy

By | April 24, 2002

The UN Biodiversity Congress last week produced guidelines to curb biopiracy but they don't satisfy ecoactivists.

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Keeping a CHEK on breast cancer

By | April 24, 2002

Mutations in the tumor suppressor genes BRCA1 and BRCA2 account for a small percentage of breast cancer cases. In 22 April Advanced Online Publication from Nature Genetics, Meijers-Heijboer and colleagues from the CHEK-Breast Cancer Consortium report the identification of a mutation in the CHEK2 gene that increases the risk of breast cancer in both women and men (Nat Genet 2002, DOI: 10.1038/ng879).They performed a genome-wide linkage search in a family with BRCA-independent breast cancer and id

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Notch determines B cell fate

By | April 24, 2002

RBP-J signaling is involved in cell fate determination of marginal zone B cells in the spleen.

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Support for use of animals in research

By | April 24, 2002

The UK government has set out in full for the first time its policy on the use of animals in medical research.

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2002 Gairdner International Awards announced

By | April 23, 2002

The 2002 awards recognize the impact of genomics, proteomics and bioinformatics.

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Anti-malarial mechanism unraveled

By | April 23, 2002

For more than 50 years antifolate drug therapy has been used successfully to treat malaria caused by Plasmodium falciparum. It had been assumed that differences between host and parasite in terms of the drug binding to dihydrofolate reductase-thymidylate synthase (DHFR-TS) were responsible for this success. But, in 19 April Science, Kai Zhang and Pradipsinh Rathod of University of Washington, Seattle, show that it may be differences in the regulation of DHFR between host and parasite that explai

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Retroviral risk

By | April 23, 2002

Gene therapy with retroviral vectors can increase the risk of developing leukemia.

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Wilson leaves UPenn's gene therapy institute

By | April 23, 2002

Director oversaw experiment that led to death of 18-year-old patient in 1999.

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Control of bone remodelling

By | April 22, 2002

Constant remodelling of bones — up to 10% of the total mass every year — helps to maintain the optimal levels of calcium in the blood and also the structural function of the skeleton, but the identity of the molecules involved in controlling this process remains unclear. In April 18 Nature, Hiroshi Takayanagi and colleagues from University of Tokyo show that interferon-β (IFN-β) is pivotal in regulating bone homeostasis (Nature 2002, 416:744-749).Takayanagi et al. observed

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