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Career counselling for embryonic cells

By | September 4, 2001

In an embryo, the stem cells develop into specific organs under the influence of complex extracellular signals. Sonic hedgehog (Shh) plays an important role in this process but its signalling pathway is not entirely understood. In August 31 Science Gurtej Dhoot and colleagues from the University of Pennsylvania Medical Center identify a member of a family of conserved sulfatases, QSulf1, which is responsive to Shh signaling and has role in embryonic cell fate determination.Dhoot et al. identifie

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Glutamate fuels brain tumor growth

By | September 4, 2001

Glutamate is one of the principal neurotransmitters in the brain, but in excess can be highly neurotoxic. In September Nature Medicine Takahiro Takano and colleagues from the New York Medical College, Valhalla, New York, show that in addition to being neurotoxic, glutamate release from glioma cells also promotes growth of malignant gliomas.Takano et al. used bioluminescence to detect glutamate release from freshly prepared brain slices. They found that implanted glioma cells continue to secrete

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throughput SIN-ning

By | September 4, 2001

A new expression cloning method based on SIN replicon particles from the Sindbis alphavirus promises high-throughput mammalian expression cloning.

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Gene profiling of immune communications

By | September 3, 2001

Early after bacterial invasion dendritic cells express IL-2, providing activation signals greatly enhancing both T and B cell responses.

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Setback for UK Synchrotron facilities, as new head takes over

By | September 3, 2001

The closure of the Daresbury synchrotron for emergency repairs emphasises the need for more of these facilities.

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Transplastomic tomatoes

By | September 3, 2001

Plastid genome engineering has created transgenic tomatoes, paving the way for the development of appetizing edible vaccines.

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Uncovering the secret to human longevity

By | August 31, 2001

One or more genes on chromosome 4 seem to influence who will live to a ripe old age.

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Viral killer

By | August 31, 2001

The ability to selectively kill cells lacking normal p53 activity is an attractive anti-cancer strategy. In the August 30 Nature, Kenneth Raj and colleagues from the Swiss Institute for Experimental Cancer Research (ISREC) suggest that adeno-associated virus (AAV) could be employed as a 'hired assassin' (Nature 2001, 412:914-917).They found that AAV induced apoptosis of p53-deficient osteosarcoma cells, but induced cell-cycle arrest (in G2 phase) in cells expressing p53. None of the proteins enc

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Not much in common

By | August 30, 2001

A comparison of the Celera and Ensembl transcriptomes examines how many predicted genes they have in common.

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The first tissue specific angiogenic mitogen

By | August 30, 2001

VEGF is a newly identified molecule that is an angiogenic mitogen selective for endocrine gland endothelium.

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