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Autoimmune diseases get the NOD

By | February 19, 2001

Observations in a mouse model of diabetes have led to the discovery of a human susceptibility locus.

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Restriction enzyme scissor cut

By | February 19, 2001

II restriction enzyme reveals an unusual scissor-like motion that allows DNA entry.

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A pathway leading to activation of BRCA1

By | February 16, 2001

Fanconi anaemia is a rare inherited disorder that causes children to develop bone marrow failure. Although a bone marrow transplant can cure the anaemia, many patients go on to develop a variety of cancers.The disorder is brought about by a mutation in any one of seven genes — five of which have been cloned. The proteins produced by these five genes form an enzyme that activates the sixth gene. Research teams led by Alan D'Andrea, of the Dana-Farber Cancer Institute in Boston, and Markus G

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a possible treatment for malignant melanoma

By | February 16, 2001

Herpes simplex virus HSV1716 replicates in and kills melanoma tumour cells, suggesting a possible therapeutic use.

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in trans

By | February 16, 2001

Experiments with irradiated mice show that damage to DNA in the paternal genome is hazardous for the maternally derived genome.

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Influenza virus propagation curbed

By | February 16, 2001

Drugs that inhibit a key signalling pathway in the human cell can halt the propagation of the influenza A virus.

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Mosquito MITEs

By | February 16, 2001

Study of the mosquito genome is driven by the need for improved strategies to control the transmission of malaria and other mosquito-borne diseases. In the February 13 Proceedings of the National Academy of Science, Tu describes the use of a novel computer program, FINDMITE, to search systematically for DNA transposable elements in the genome of the African malaria mosquito Anopheles gambiae (Proc Natl Acad Sci USA 2001, 98:1699-1704). The program identified eight novel families of miniature inv

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A single gene drives endocrine pancreatic development

By | February 15, 2001

pancreatic islet cells.

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B help surgeons?

By | February 15, 2001

B in neutrophils may predict the risk of multiple organ dysfunction syndrome after major surgery.

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Inflammatory bowel disease linkage with chromosome 3p

By | February 15, 2001

Inflammatory bowel disease (IBD) is a group of conditions having an unknown cause, but with a genetic component clearly demonstrated by epidemiological and linkage studies. A link with chromosome 3 is suggested by observations of a gene, or perhaps multiple genes, involved in regulating immune function and inflammatory response that reside in this region of the genome.In the February issue of Gut, a team from the US, UK, Germany and the Netherlands published the results from a high resolution li

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