Advertisement
Gene Tools
Gene Tools

News & Opinion

Covering the life sciences inside and out

Most Recent

The sticking place

By | January 11, 2001

Platelets are central to the process of wound healing. But overly responsive platelets could block normal blood flow, particularly where atherosclerosis exists, resulting in stroke, myocardial infarction and unstable angina. Hence the interest in studying the receptors for platelet-activating substances released from damaged vessels, like ADP.In 11 January Nature, Pamela B. Conley of COR Therapeutics, California, and colleagues report that they have cloned the ADP receptor P2Y12 and showed that

0 Comments

FANCY metabolomics

By | January 10, 2001

In the January Nature Biotechnology, Raamsdonk et al. find that, even when mutation of a gene causes no obvious phenotype, metabolite profiling can still give clues to gene function (Nat Biotechnol 2001, 19:45-50). Their test case involves two yeast strains deleted for either one of the two redundant genes for 6-phosphofructo-2-kinase (6-PF-2-K). These deletion strains fail to show a growth defect, even in chemostat competition experiments, but an analysis of specific metabolites clearly sets th

0 Comments

Evolution caught in the act

By | January 8, 2001

Duplication, deletion and mutation have created a new gene, denoted Sdic, that encodes a fly sperm axoneme protein. Sdic is present in the fly Drosophila melanogaster, but not in its close relative Drosophila simulans. In the 5 January Science, Nurminsky et al. find evidence for a selective sweep around Sdic in D. melanogaster (Science 2001, 291:128-130). D. melanogaster DNA has a significant depression in the level of synonymous polymorphism around Sdic, and an increase in the occurrence of rar

0 Comments

Loopy expression

By | January 8, 2001

Yeast is unusual in that its transcriptional activators cannot work over long distances. But in the 4 January Nature, de Bruin et al. report that the looping of heterochromatic-like telomere regions corrects this shortcoming (Nature 2001, 409:109-113). They place a binding site for the activator Gal4 downstream of a reporter gene. The site is inactive when the reporter is at an internal chromosomal locus, but active when the gene cassette is placed, in either orientation, near the telomere. Only

0 Comments

Shocking phosphorylation of histones

By | January 8, 2001

Histone modifications are required to gain access to DNA sequences within the tightly compacted genome and enable gene transcription. It has been proposed that acetylation of the amino-terminal tails of the core histones within the nucleosome particle is critical for activating transcription. In the December Genes and Development, Nowak and Corces suggest that histone phosphorylation may play a greater role than acetylation in gene induction (Genes Dev 2000, 14:3003-3013). They studied the he

0 Comments

SNPs by SPR

By | January 8, 2001

Approximately 1.6 million single nucleotide polymorphisms (SNPs) have been identified and deposited in public databases, but more are always needed for studies of other species and identification of mutations in candidate disease genes. In the January Nature Biotechnology, Nakatani et al. outline a new method for SNP identification using capture by a mismatch-specific ligand followed by surface plasmon resonance (SPR; Nat Biotechnol 2001, 19:51-55). The ligand, a dimeric naphthyridine, intercala

0 Comments

The ins and outs of data

By | January 8, 2001

Germany's Max Planck Society is setting up a Centre for Information Management that aims to give its researchers greater power over the way their work is published.

0 Comments

Cycling surprises

By | January 5, 2001

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify 731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare d

0 Comments

Age-related macular degeneration (AMD) is the leading cause of blindness in individuals over 55 years of age in the developed world. AMD affects about 11 million Americans, 5 million of whom have become legally blind because of it. Stargardt's macular degeneration (STGD3) is an early-onset form of AMD that affects about 30,000 children and young adults in the United States. Researchers reported in this week's Nature Genetics that they have identified a gene linked to AMD and predicted the discov

0 Comments

Have the will, have the data

By | January 5, 2001

Referees on strike, and a new "template" for academic electronic publishing; sound familiar? This time it's economists on the warpath, and they have figures to shoot with.

0 Comments

Follow The Scientist

icon-facebook icon-linkedin icon-twitter icon-vimeo icon-youtube
Advertisement

Stay Connected with The Scientist

  • icon-facebook The Scientist Magazine
  • icon-facebook The Scientist Careers
  • icon-facebook Neuroscience Research Techniques
  • icon-facebook Genetic Research Techniques
  • icon-facebook Cell Culture Techniques
  • icon-facebook Microbiology and Immunology
  • icon-facebook Cancer Research and Technology
  • icon-facebook Stem Cell and Regenerative Science
Advertisement
Advertisement
The Scientist
The Scientist
Life Technologies