Advertisement

News & Opinion

Covering the life sciences inside and out

Most Recent

A lentiviral vector that carries a neurotrophic factor into the brain seems to reverse symptoms of Parkinson's disease in monkeys, raising hopes that it could also be effective in humans.

0 Comments

Replication coupled to recombination

By | October 31, 2000

Blocking meiotic DNA replication in budding yeast prevents recombination initiation. This could indicate a direct coupling of the two processes, or the presence of a checkpoint system that detects incomplete replication and shuts down the formation of double-strand breaks (DSBs). In the 27 October Science, Borde et al. report that budding yeast cells defective for the replication checkpoint can progress through meiosis I in the absence of replication, but DSBs are still not formed (Science 2000,

0 Comments

Error-filled embryos

By | October 27, 2000

Humans are incredibly inefficient when it comes to reproduction. Fertile couples have only a 25% chance of achieving a viable pregnancy per menstrual cycle. Now, in the November Molecular Human Reproduction, Wells and Delhanty suggest that the low success rate may be explained by the high incidence of chromosomal abnormalities in early embryos, many of which never reach the stage of implantation (Mol Hum Reprod 2000, 6:1055-1062). In previous research, fluorescent in-situ hybridization (FISH) me

0 Comments

BSE Inquiry out in the open

By | October 26, 2000

The results of the UK government's BSE Inquiry were published on Thursday 26 October, implicating civil servants and scientists in the health scandal.

0 Comments

Selective remodelling

By | October 25, 2000

DNA-binding transcription factors can target the SWI/SNF chromatin remodelling complex to specific nucleosome sites.

0 Comments

Smoking selects mutants

By | October 25, 2000

In the October 24 Proceedings of the National Academy of Sciences Rodin and Rodin propose that smoking leads to increased lung cancer not by causing more mutations, but by selecting for those mutations that do arise (Proc Natl Acad Sci USA 2000, 97:12244-12249). They take advantage of an increase in p53 mutational data in nonsmokers and find, for example, that the frequency of silent mutations in p53 is identical between smokers and non-smokers. In contrast, twice as many lung cancers from smoke

0 Comments

Solving protein folding in your lunch break

By | October 25, 2000

While you take time out to eat your lunch, your computer could be busy helping crack one of the biggest challenges of modern biology.

0 Comments

and cot death

October 24, 2000

A strong link has been found between the bacterium Helicobacter pylori and cot death. H. pylori is a bacterium of the gut that can cause stomach infections and peptic ulcers. It is common in adults but rare in babies in the UK, yet evidence of its presence has been found in the windpipe of a proportion of babies who have died from sudden infant death syndrome (SIDS).Researchers from Manchester Royal Infirmary examined tissue samples taken from the stomach, windpipe and lung of 32 infants aged be

0 Comments

A recent study suggests that features of the coronary vasculature, as detected on angiography, can predict the occurrence and timing of infarcts.

0 Comments

dsRNA can turn off genes

By | October 23, 2000

RNA interference (RNAi) is an elegant technique in which double-stranded RNA (dsRNA) can direct the degradation of homologous RNA species leading to post-transcriptional gene silencing. In the October 2 EMBO Journal Mette et al. extend dsRNA applications by showing that dsRNA corresponding to sequences from the nopaline synthase promoter (NOSpro) could disrupt transcriptional activation (EMBO Journal 2000, 19:5194-5201). The dsRNA trans-silencing was accompanied by induced methylation of the tar

0 Comments

Follow The Scientist

icon-facebook icon-linkedin icon-twitter icon-vimeo icon-youtube
Advertisement

Stay Connected with The Scientist

  • icon-facebook The Scientist Magazine
  • icon-facebook The Scientist Careers
  • icon-facebook Neuroscience Research Techniques
  • icon-facebook Genetic Research Techniques
  • icon-facebook Cell Culture Techniques
  • icon-facebook Microbiology and Immunology
  • icon-facebook Cancer Research and Technology
  • icon-facebook Stem Cell and Regenerative Science
Advertisement
UVP
UVP
Advertisement
The Scientist
The Scientist