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Platelet glycoprotein IIb/IIIa should be blocked before stenting

By | December 15, 2000

Eptifibatide, a platelet glycoprotein IIb/IIIa inhibitor substantially reduces ischemic complications in coronary stent interventions and could become a routine pre-treatment in stent coronary implantation, concludes a study published in 16 December Lancet (Lancet 2000 356:2037).In a prospective study, Dr James Tcheng and colleagues from Duke University Medical Centre in North Carolina recruited 2064 patients who were undergoing coronary stent implantation. Immediately before the procedure, pati

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The plant clock

By | December 15, 2000

Previous analyses of the circadian clock in the plant Arabidopsis thaliana have turned up just a few genes regulated by the clock. In the 15 December Science, Harmer et al. use oligonucleotide-based arrays to find a vast new collection of clock-regulated genes (Science 2000, 290:2110-2113). Using probes derived from tissue harvested every four hours, and an array representing 8,200 different genes, Harmer et al. find that 453 genes (6%) fit a cosine test wave with a period between 20 and 28 hour

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- or is it the other way around?

By | December 14, 2000

Donald Kennedy.

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Clinical alerts have an immediate effect on medical practice

By | December 14, 2000

A recent study shows that disseminating the results of clinical trials before publication in peer-reviewed journals can change medical practice promptly and significantly.

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Fibrinogen, stroke and obstructive sleep apnea

By | December 14, 2000

Patients with ischemic stroke and obstructive sleep apnea (OSA) have elevated fibrinogen levels which correlate positively with apnea severity.

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Media campaign reduces smoking deaths

By | December 14, 2000

The Golden State offers evidence that funding media campaigns reduces smoking-related deaths.

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Plant sequence completed

By | December 14, 2000

gives us an idea of how plants function.

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Go to the end of the Ku

By | December 13, 2000

Telomeres are specialized structures at the ends of chromosomes that prevent fusion events and promote chromosomal end replication. Telomeres are maintained by the regulation of telomerase activity and their capping by telomeric proteins. In the November Genes and Development, Hsu et al. show that the DNA repair protein Ku plays a role in telomere capping (Gene Dev 2000, 14:2807-2812). Hsu et al. used surface plasma resonance and co-immunoprecipitation to demonstrate that Ku forms a high-affini

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Rax2 marks the spot

By | December 13, 2000

Haploid yeast cells bud next to the site of the previous division (axial pattern), but diploid yeast cells bud from their poles (bipolar pattern). In the 8 December Science, Chen et al. propose that the Rax2 protein marks the cortex to provide a landmark for bipolar budding (Science 2000, 290:1975-1978). Rax2 is an integral membrane protein, discovered following a hunt for mutants defective in bipolar budding. Late in the cell cycle, Rax2 protein localizes to rings associated with division sites

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Rock, paper, scissors, lizard

By | December 13, 2000

Male side-blotched lizards (Uta stansburiana) have three heritable throat colors, associated with three divergent mating strategies. In the 19 December Proceedings of the National Academy of Sciences, Zamudio and Sinervo find that these alternative mating strategies can stably coexist because, as in a game of rock, paper, scissors, each strategy has strengths over one other, and weaknesses in the face of the third (Proc Natl Acad Sci USA 2000, published online ahead of print). The strategy of bl

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