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Bop controls ventricle formation

By | April 8, 2002

encodes a muscle-restricted protein essential for cardiac differentiation and right ventricle morphogenesis.

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primase inhibitors may treat herpes

By | April 8, 2002

primase inhibitors are orally available drugs active against herpes simplex virus.

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Send in the clones

By | April 8, 2002

The US patent office has waded in to the dispute over who was first to develop cloning technology.

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Gene therapy rebuilds immunity and its image

By | April 5, 2002

Researchers at Great Ormond Street Children's Hospital strengthen the case for gene therapy as a treatment for immunodeficiencies.

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New vaccine hopes for cancer

By | April 5, 2002

Tumor cells covered with a T cell ligand-mimicking antibody fragment can initiate their own destruction.

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The genome that feeds the world

By | April 5, 2002

Two independent groups report draft sequences of the rice genome.

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The silencing team

By | April 5, 2002

Inactivation of tumor suppressor genes is an essential stage in the development of human cancer but the extent of the involvement of epigenetic silencing and hypermethylation in this process remains unclear. In April 4 Nature, Ina Rhee and colleagues from Johns Hopkins University School of Medicine, show that two enzymes (DNMT1 and DNMT3b) cooperate to silence genes and maintain DNA methylation in human cancer cells.Rhee et al. worked on a colorectal cancer cell line and observed that only genet

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Maternal antibodies and diabetes

By | April 4, 2002

reactive autoantibodies prevents diabetes in nonobese diabetic mice.

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Protein polymorphisms

By | April 4, 2002

In an Advanced Online Publication from Nature Genetics, Klose at al. describe a comprehensive genetic study of proteins in the murine brain (Nat Genet 2002, DOI:10.1038/ng861).They took advantage of crosses from the European collaborative interspecific backcross (EUCIB) project, and prepared brain tissues from 200 backcross progeny (B1) animals. Klose at al. then analyzed the brain proteome using two-dimensional gel electrophoresis. Comparison of over 8000 gel spots from two distantly related mo

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Publication with a pinch of privatisation

By | April 4, 2002

yet again bends the rules in publishing the rice genome, opinions are strongly divided on whether this should be the shape of things to come.

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