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Setback for UK Synchrotron facilities, as new head takes over

By | September 3, 2001

The closure of the Daresbury synchrotron for emergency repairs emphasises the need for more of these facilities.

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Transplastomic tomatoes

By | September 3, 2001

Plastid genome engineering has created transgenic tomatoes, paving the way for the development of appetizing edible vaccines.

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Uncovering the secret to human longevity

By | August 31, 2001

One or more genes on chromosome 4 seem to influence who will live to a ripe old age.

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Viral killer

By | August 31, 2001

The ability to selectively kill cells lacking normal p53 activity is an attractive anti-cancer strategy. In the August 30 Nature, Kenneth Raj and colleagues from the Swiss Institute for Experimental Cancer Research (ISREC) suggest that adeno-associated virus (AAV) could be employed as a 'hired assassin' (Nature 2001, 412:914-917).They found that AAV induced apoptosis of p53-deficient osteosarcoma cells, but induced cell-cycle arrest (in G2 phase) in cells expressing p53. None of the proteins enc

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Not much in common

By | August 30, 2001

A comparison of the Celera and Ensembl transcriptomes examines how many predicted genes they have in common.

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The first tissue specific angiogenic mitogen

By | August 30, 2001

VEGF is a newly identified molecule that is an angiogenic mitogen selective for endocrine gland endothelium.

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An alternative for toll pathway

By | August 29, 2001

Toll-like receptor 4 uses the TIRAP cytoplasmic adapter protein as an alternative route to induce immune responses.

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An oncogene with a split personality

By | August 29, 2001

oncogene could play an important role in the next generation of cancer treatments.

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Cocaine addiction linked to a glutamate receptor

By | August 29, 2001

A previously overlooked glutamate receptor expands our understanding of the neurological basis of learning and addiction.

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Regulating p53

By | August 29, 2001

MDM2 is an E3 ubiquitin ligase that regulates the activity of p53 by controlling degradation of the p53 protein, as a result of differential addition of ubiquitin. In the Advanced Online Publication of Nature Genetics, Parant et al. report the phenotype of mice lacking the recently cloned MDM2-related protein MDM4 (DOI:10.1038/ng714).They show that mdm4-null mice die at embryonic day 7.5-8.5. Analysis of the incorporation of the nucleotide analogue BrdU and TUNEL staining for apoptotic cells sho

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