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Schizophrenic NOTCH?

By | June 5, 2001

A recent report linked the human NOTCH4 locus with susceptibility to schizophrenia. In the June issue of Nature Genetics, two reports cast doubt on the NOTCH4-schizophrenia association. Sklar et al. conducted a large-scale study involving 519 parent-offspring trios in three independent families (compared to 80 trios in the original linkage study; Nature Genetics 2001, 28:126-128). Extensive association analyses failed to confirm the previous linkage results. McGinnis et al. analysed (CTG)n and

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Single amino acid can change progression to AIDS

By | June 5, 2001

A single amino acid change in HLA molecules can have a substantial effect on the rate of progression to AIDS in patients infected with HIV-1.

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Antigen-specific T cell-mediated gene therapy

By | June 4, 2001

Antigen-specific T cell-mediated gene therapy can inhibit the development of collagen-induced arthritis, a murine model of rheumatoid arthritis.

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Apoptosis and disease in plants

By | June 4, 2001

Animal anti-apoptotic genes can defend transgenic plants against pathogen attack.

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The role of macrophage aP2 in atherosclerosis

By | June 4, 2001

binding protein aP2 protects transgenic mice deficient in apolipoprotein E against atherosclerosis.

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New line of research on cocaine addiction

By | June 1, 2001

A new study suggests that a single dose of cocaine primes the brain for addiction.

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Shear forces promote lymphocyte migration

By | June 1, 2001

Continuous force or shear stress from fast flowing fluid must be applied on adherent white blood cells to facilitate migration across endothelium.

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ssDNA Tools

By | June 1, 2001

Single-stranded oligonucleotides may provide a new tool for homologous recombination and genome modification.

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Statins can block inflammation

By | June 1, 2001

LFA703, a statin with high binding affinity for the LFA-1 site but low activity against HMG-CoA reductase has increased anti-inflammatory effects.

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Training microarrays

By | June 1, 2001

Artificial neural networks can help in applying microarray data to tumour diagnosis.

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