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The joint gene

By | February 21, 2001

The locations at which joints arise during foetal development are essential for determining the final skeletal pattern and are also strongly implicated in a number of joint diseases. At present little is known about the complicated molecular mechanisms involved in joint formation. In the February Cell, researchers from the Department of Genetics, Harvard Medical School suggest that Wnt-14 is essential in the initial steps of joint formation.Christine Hartmann and Clifford Tabin studied the early

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UK gene bank a step closer

By | February 21, 2001

Three countries have already started collecting genetic information from their population in a bid to improve health, and the UK is not far behind. As details of the project start to emerge we look at what shape this study is going to take and what information it might yield.

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Autoimmune diseases get the NOD

By | February 19, 2001

Observations in a mouse model of diabetes have led to the discovery of a human susceptibility locus.

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Restriction enzyme scissor cut

By | February 19, 2001

II restriction enzyme reveals an unusual scissor-like motion that allows DNA entry.

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A pathway leading to activation of BRCA1

By | February 16, 2001

Fanconi anaemia is a rare inherited disorder that causes children to develop bone marrow failure. Although a bone marrow transplant can cure the anaemia, many patients go on to develop a variety of cancers.The disorder is brought about by a mutation in any one of seven genes — five of which have been cloned. The proteins produced by these five genes form an enzyme that activates the sixth gene. Research teams led by Alan D'Andrea, of the Dana-Farber Cancer Institute in Boston, and Markus G

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a possible treatment for malignant melanoma

By | February 16, 2001

Herpes simplex virus HSV1716 replicates in and kills melanoma tumour cells, suggesting a possible therapeutic use.

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in trans

By | February 16, 2001

Experiments with irradiated mice show that damage to DNA in the paternal genome is hazardous for the maternally derived genome.

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Influenza virus propagation curbed

By | February 16, 2001

Drugs that inhibit a key signalling pathway in the human cell can halt the propagation of the influenza A virus.

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Mosquito MITEs

By | February 16, 2001

Study of the mosquito genome is driven by the need for improved strategies to control the transmission of malaria and other mosquito-borne diseases. In the February 13 Proceedings of the National Academy of Science, Tu describes the use of a novel computer program, FINDMITE, to search systematically for DNA transposable elements in the genome of the African malaria mosquito Anopheles gambiae (Proc Natl Acad Sci USA 2001, 98:1699-1704). The program identified eight novel families of miniature inv

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A single gene drives endocrine pancreatic development

By | February 15, 2001

pancreatic islet cells.

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