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Sand fly saliva spits out Leishmania vaccine

By | August 7, 2001

A DNA vaccine derived from a sand fly saliva protein could protect against vector borne parasitic diseases.

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Two-hybrid assay in plants

By | August 7, 2001

protein-fragment complementation assay can monitor protein-protein interactions in living plant cells.

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Myotonic expansion

By | August 6, 2001

Myotonic dystrophy (DM) is the most common form of adult muscular dystrophy. DM Type 1 caused by expansion of a CTG repeat in the 3' untranslated region of the dystrophia myotonica-protein kinase (DMPK) gene. In the August 3 Science, Christina Liquori and colleagues from the University of Minnesota report that DM2 is also caused by microsatellite expansion in non-coding sequences (Science 2001, 293:864-867). While characterizing the DM2 locus on chromosome 13q21, Liquori et al. discovered an exp

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Perfect murder

By | August 6, 2001

In the August issue of Nature Biotechnology, Francesca Sotrici and colleagues from the National Institute of Environmental Health Sciences describe how to commit the perfect murder (Nature Biotechnology 2001, 19:773-776). "Delitto perfetto" (Italian for perfect murder) is the name they gave to a two-step, cloning-free, technique that creates desired mutations, be they simple nucleotide replacements, precise insertions or large deletions. The first step involves integration of a counterselectable

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Putting the sea into cancer therapy

By | August 3, 2001

Tampering with the nucleotide excision DNA repair mechanism creates lethal breaks in the DNA and can kill cancerous cells.

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Adiponectin reverses insulin resistance

By | August 2, 2001

Adiponectin, a natural substance secreted by fat cells, appears to reverse the effects of insulin resistance and to lower blood glucose levels.

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Antibodies could combat prion-based diseases

By | August 2, 2001

The discovery that antibodies seem to be effective against prions could open the door to immunisation against spongiform encephalopathies.

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Marine anticancer drug works by novel mechanism

By | August 2, 2001

A sea squirt extract is showing considerable promise in the treatment of a number of types of bone and soft-tissue cancers.

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a new class of AIDS drugs

By | August 1, 2001

As HIV continues to develop resistance to the present antiretrovirals a new class of drugs offer hope for the treatment of AIDS.

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Faces and races in the human brain

By | August 1, 2001

Same-race faces elicit more activity in brain regions linked to face recognition.

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