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Paradoxical role of proteinase inhibitors in cystic fibrosis

By | December 28, 2000

-antichymotrypsin is associated with less severe pulmonary disease in patients with cystic fibrosis.

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Hot DNA

By | December 22, 2000

In the December 19 Proceedings of the National Academy of Sciences, Kawashima et al. compare their sequence of Thermoplasma volcanium with existing genomic sequences of seven other archaeons, and find that thermophiles adapt to increasing heat by clustering purines and pyrimidines, and by making more basic proteins (Proc Natl Acad Sci USA 2000, 97:14257-14262). The frequency of purine or pyrimidine dinucleotides in the genomic sequences rises with increasing optimum growth temperature (OGT), as

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Immunizing against Alzheimer's

By | December 22, 2000

Immunization with amyloid-beta peptide reduces the learning deficits seen in mouse models of Alzheimer's disease.

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SWI/SNF is a tumour suppressor

By | December 22, 2000

The SNF5 protein (also called INI1) is a subunit common to two closely related mammalian SWI/SNF complexes that function as chromatin-remodeling machines. The human gene, hSNF5, is mutated in early childhood malignant rhabdoid tumors (MRT). In the December EMBO Reports, Klochendler-Yeivin et al. describe a mouse model for SNF5 deficiency (EMBO Reports 2000, 1:500-506). Knockout mice embryos lacking a functional SNF5 gene die shortly after implantation. Experiments with blastocytes in culture sho

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Targeted methylation

By | December 22, 2000

Introducing methylated DNA at specific genomic loci affects local histone acetylation.

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UK health service launches electronic library

By | December 22, 2000

LONDON The UK's National Health Service (NHS) has launched a pilot version of an online library that will provide health care professionals with the knowledge and know-how to support health care decisions. With the stated aim of becoming of becoming "one of the greatest libraries of the world," the National electronic Library for Health (NeLH) will provide fast access to the latest thinking in health care services but will also act as a filter to ensure the reliability of the information it lin

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Is the FDA's drug review process breaking down?

By | December 20, 2000

Since 1997 the US FDA has banned use of 11 prescription drugs because of serious side effects. The FDA says it's not the drug approval process but inappropriate prescribing that is responsible.

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MPs say 'yes' to stem cell research

By | December 20, 2000

British Members of Parliament have voted in favour of allowing therapeutic cloning.

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Cardiovascular effects of 'ecstasy' revealed

By | December 19, 2000

The drug ecstasy produces dose-related increases in myocardial oxygen demand without an increase in contractility.

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Estrogens and bone density in elderly men

By | December 19, 2000

Decreased serum estradiol levels, not testosterone levels, are predictive of osteopenia in older men.

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