February 6, 2001|
The human intestine is home to numerous populations of microorganisms, but we know little about how the gut microflora influence our physiology. As described in the February 2 Science, Hooper et al. took a genomics approach to investigate the affect of resident bacteria on host gene expression in the gut (Science 2001, 291:881-884). The authors infected germ-free mice with the common gut bacterium Bacteroides thetaiotaomicron and measured host transcriptional responses using microarray analysis.