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Pseudomonas aeruginosa

By | January 3, 2001

Now that the structure of the N-terminal domain of exotoxin S has been revealed, perhaps a drug target will present itself.

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Calling all binding sites

By | December 29, 2000

In the 22 December Science Ren et al. combine chromatin immunoprecipitation with DNA microarrays to identify all binding sites for two budding yeast transcription activators (Science 2000, 290:2306-2309). They start by breaking open cells, cross-linking bound protein to DNA, sonicating, and immunoprecipitating with an antibody against a particular transcription factor. The isolated DNA is amplified, and the abundance of the amplified fragments is compared with a whole genome amplification using

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Keeping up the weight loss

By | December 29, 2000

Just in time for the New Year's resolution. A randomised, double blind trial suggests that the drug, sibutramine, previously known for inducing dose-dependent weight loss and enhancing the effects of a low-calorie diets, is effective in sustaining weight loss (Lancet 2000; 356: 2119-25). The international team of researchers, lead by Professor W Philip T James from Aberdeen, UK, studied 605 obese patients recruited from eight European centres. The patients were enrolled in a 6-month period of we

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GMC under attack

By | December 28, 2000

The medical community has become split over what to do with its overseeing body, the GMC. Can it reform itself, or will Government have to step in?

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Inverted yeast

By | December 28, 2000

After comparing the genomic sequences of the two yeast species Saccharomyces cerevisiae and Candida albicans, Seoighe et al. report in the December 19 Proceedings of the National Academy of Sciences that gene adjacencies have been broken as frequently by small inversions as by translocations or long-distance transpositions (Proc Natl Acad Sci USA 2000, 97:14433-14437). Only 9% of gene pairs that are adjacent in one species are conserved as adjacent in the other, and the number of orientation cha

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Oesophagitis is linked to exposure to aeroallergens, mediated by interleukin-5.

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Paradoxical role of proteinase inhibitors in cystic fibrosis

By | December 28, 2000

-antichymotrypsin is associated with less severe pulmonary disease in patients with cystic fibrosis.

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Hot DNA

By | December 22, 2000

In the December 19 Proceedings of the National Academy of Sciences, Kawashima et al. compare their sequence of Thermoplasma volcanium with existing genomic sequences of seven other archaeons, and find that thermophiles adapt to increasing heat by clustering purines and pyrimidines, and by making more basic proteins (Proc Natl Acad Sci USA 2000, 97:14257-14262). The frequency of purine or pyrimidine dinucleotides in the genomic sequences rises with increasing optimum growth temperature (OGT), as

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Immunizing against Alzheimer's

By | December 22, 2000

Immunization with amyloid-beta peptide reduces the learning deficits seen in mouse models of Alzheimer's disease.

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SWI/SNF is a tumour suppressor

By | December 22, 2000

The SNF5 protein (also called INI1) is a subunit common to two closely related mammalian SWI/SNF complexes that function as chromatin-remodeling machines. The human gene, hSNF5, is mutated in early childhood malignant rhabdoid tumors (MRT). In the December EMBO Reports, Klochendler-Yeivin et al. describe a mouse model for SNF5 deficiency (EMBO Reports 2000, 1:500-506). Knockout mice embryos lacking a functional SNF5 gene die shortly after implantation. Experiments with blastocytes in culture sho

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