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Nephrogenesis profiling

By | May 4, 2001

Kidney organogenesis is a complex process involving mesenchymal-epithelial transformation, branch morphogenesis and terminal differentiation. In the May 8 Proceedings of the National Academy of Sciences, Stuart et al. describe a microarray analysis of 8,740 rat genes during kidney development (Proc Natl Acad Sci USA 2001, 98:5649-5654). The authors developed data-analysis software for data equalization, statistical-significance testing and data mining. About 10% of genes were found to vary signi

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Neural progenitor cells from cadavers

By | May 4, 2001

In the 3 May Nature, Fred Gage and colleagues of the Salk Institute in La Jolla, California report the successful isolation and propagation of neural progenitor tissue from post-mortem brain tissue (Nature 2001, 411:42-43).Two hours post mortem brain tissue was removed from an 11-week-old neonate and a 27-year-old adult. The samples were placed in cold antibiotic-containing Hank's buffered salt solution and processed for cell culture 3 hours later. Representative sections of the hippocampus, ven

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Amplicon analysis

By | May 3, 2001

The chromosomal region 17q23 is amplified in some cancer cells and is associated with poor prognosis for breast cancer. In the May 8 Proceedings of the National Academy of Sciences, Monni et al. describe the use of genomic and microarray analysis to characterize the 17q23 amplicon in breast cancer cells (Proc Natl Acad Sci USA 2001, 98:5711-5716). They constructed a 4 megabase contig covering the amplified region of chromosome 17, containing 17 genes and 26 expressed sequence tags (ESTs) identif

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Anorexia susceptibility gene variant identified

By | May 3, 2001

has been found more frequently in patients with anorexia nervosa than in controls.

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BDNF boost

By | May 3, 2001

In the 3 May Nature Oliver Guillin and colleagues report that the expression of the dopamine D3 receptor is regulated by the brain-derived neurotrophic factor (BDNF), a protein once thought to be needed simply for the proliferation and survival of neurons (Nature 2001, 411:86-89).D3 receptors are expressed mainly in an area of the brain known as the shell of the nucleus accumbens. Neurons from the ventral tegmental area (VTA), which produce both dopamine and BDNF, connect to neurons of the nucle

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VIP treatment for arthritis

By | May 2, 2001

Vasoactive intestinal peptide prevents experimental arthritis by downregulating both autoimmune and inflammatory responses.

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Yeasts: the basis for new vaccines

By | May 2, 2001

mediated response and protective immunity in mice.

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Cloned stem cells

By | May 1, 2001

Pluripotent stem cells hold promise for transplantation therapy to treat degenerative diseases, but isolating a patient's stem cells may pose a technical limitation. In the April 27 Science, Wakayama et al. describe the application of cloning to generate embryonic stem (ES) cells (Science 2001, 292:740-743). The authors used nuclei from adult-derived somatic donor cells of five different strains of mice to produce cloned blastocysts. These were then used to derive 35 different nuclear transfer E

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Deficient domain protein reveal pathway for cardiomyopathy

By | May 1, 2001

associated LIM gene destabilizes actin anchorage sites in cardiac muscle.

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Genetic susceptibility to infertility

By | May 1, 2001

Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.

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