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Defective axonal transport in Alzheimer's disease

By | December 11, 2001

The normal function of amyloid precursor protein, involved in Alzheimer's disease, is to transport cellular materials along the axons.

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Regulating adeno-associated virus

By | December 11, 2001

Adeno-associated virus is an attractive vector for gene therapy as it is non-pathogenic and integrates into a specific site in the human genome. In the December 11 Early Edition of the Proceedings of the National Academy of Sciences, Toni Cathomen and colleagues, at The Salk Institute for Biological Studies in California describe a genetic screen for cellular proteins that can bind to a viral DNA sequence important for replication and integration (Proc Natl Acad Sci USA, 2001 10.1073/pnas.261567

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Stroke risk factor steps into the limelight

By | December 11, 2001

Blood triglyceride levels could be an important indicator of an individual's risk of having a stroke.

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With Pals like these

By | December 11, 2001

Asymptomatic nasopharyngeal carriers of Streptococcus pneumoniae can be a reservoir for severe pneumonia in children and the elderly, but there is no treatment regime that can specifically reduce the number of pneumococci without affecting the normal indigenous mucosal flora. In December 7 Science, Jutta Loeffler and colleagues from The Rockefeller University, New York, show that seconds after contact, a purified pneumococcal bacteriophage lytic enzyme (Pal) is able to kill common pneumococci, i

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Amplifying the signal

By | December 10, 2001

Non-invasive imaging of reporter gene expression offers a powerful tool for monitoring spatial and temporal expression in live animals (or people). One limitation of such techniques is the low expression of genes driven by tissue-specific promoters. In the December 4 Proceedings of the National Academy of Sciences, Iyer et al. describe using a two-step transcriptional amplification (TSTA) approach to amplify the signal for non-invasive detection (Proc Natl Acad Sci USA 2001, 98:14595-14600).They

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Key to 'wasting syndrome'

By | December 10, 2001

inhibits transcription of the albumin gene and could lead to cachexia.

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What the public really, really wants

By | December 10, 2001

The healthcare priorities expressed by the British public differ significantly from those of the biomedical community.

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Back to the drawing board for CJD treatment

By | December 7, 2001

The death of woman with CJD being treated with a novel drug combination casts doubts on the 'miracle cure' claim for the disease.

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Enhancing T cell activation

By | December 7, 2001

antigen-presenting cell interface.

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End-joining in yeast

By | December 6, 2001

Two genes have been found to down-regulate the non-homologous end-joining pathway in meiotic diploid yeast cells.

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