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plays a pivotal role in pulmonary fibrosis

By | June 20, 2001

Pulmonary fibrosis is considered a deleterious consequence of persistent lung inflammation, but the mechanism by which inflammation leads to fibrosis remains incompletely understood. In June 15 Journal of Clinical Investigation, Martin Kolb and colleagues from McMaster University, Ontario, Canada, show how acute tissue injury in the lung — initiated by a highly proinflammatory cytokine — IL-1β, converts to progressive fibrotic changes.Kolb et al. used adenoviral gene transfer to

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Sickle cell adhesion mechanism

By | June 20, 2001

induced signal transduction.

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Evolutionary ESTs

By | June 19, 2001

Comparative analysis of expressed sequence tags (ESTs) identifies rapidly evolving proteins in the reproductive glands of male flies.

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Step-by-step account of HIV-1 infection

By | June 19, 2001

In response to HIV-1 infection immune cells decrease mRNA synthesis, suppress DNA repair gene transcripts and increase expression of apoptosis inducing genes.

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Viral protein K5 modulates T cell costimulation

By | June 19, 2001

in B cells dramatically reduces ICAM-1 and B7-2 surface expression, impairing B cell induction of T cell activation.

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Coral bleaching aids survival in changing environments

By | June 18, 2001

Coral bleaching, traditionally thought to be a response to adverse environmental conditions, may help corals survive in changed environments.

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Receptor structure predicts drug interactions

By | June 18, 2001

The human nuclear pregnane X receptor has a hydrophobic ligand-binding cavity with a small number of polar residues that are critical for precise pharmacologic activation.

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The dangers of vitamin C

By | June 18, 2001

show that vitamin C induces the formation of genotoxins, explaining why it has proved ineffective as a cancer therapeutic agent.

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a two-edged sword?

By | June 15, 2001

Vitamin C could promote production of DNA-damaging compounds and may help explain why vitamin C has thus far shown little effectiveness at preventing cancer in clinical trials.

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Events at the ends

By | June 15, 2001

Telomere position effects in human cells may account for gene expression changes as cells grow older.

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