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2D gels are not enough

By | August 17, 2000

A series of narrow-pH-range overloaded 2D gels, processed using sensitive silver-staining, yields enough spots that the gels could, theoretically, be surveying virtually all of the proteins of budding yeast. But in the August 15 Proceedings of the National Academy of Sciences, Gygi et al. report that proteomics proponents may have been fooling themselves (Proc Natl Acad Sci USA 2000, 97:9390-9395). Gygi et al. select a random region of one such gel and analyze all the visible spots. The genes co

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A sea urchin genome project

By | August 17, 2000

Sea urchins are popular in developmental biology research thanks to their well defined embryology, the ease of gene transfer into eggs, and the abundance of eggs for biochemical work. Now the sea urchin genome project is off to a start with sequence from the ends of 76,020 bacterial artificial chromosome (BAC) recombinants. In the August 15 Proceedings of the National Academy of Sciences, Cameron et al. report that these sequence tag connectors (STCs) occur at an average of 10 kb apart in the s

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Choosing hearts to treat

By | August 17, 2000

A TIMI prognostication scheme is clinically useful in cardiac patients.

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Coronary risk factors

August 17, 2000

NEW YORK, Aug 15 (Praxis Press) Ultrasound measurements of carotid arterial intimal-medial thickness, a measure of atherosclerosis, are increasingly used as cardiovascular endpoints in clinical studies, but the association of carotid atherosclerosis and major coronary risk factors is unknown. Mannami and colleagues evaluated the relationship between major coronary risk factors (hypertension, smoking, and hypercholesterolemia) and ultrasound measures of carotid atherosclerosis in 3,998 Japanese m

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How you got that clot

By | August 17, 2000

Elevated plasma factor VIII predicts recurrent venous thromboembolism.

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Hysterectomy

August 17, 2000

NEW YORK, Aug 14 (Praxis Press) Women are routinely cautioned about the immediate risks of serious complications and death associated with elective hysterectomy, but are often not counseled about the possible long-term sequelae. Brown and colleagues reviewed 12 articles that addressed the development of incontinence in women after hysterectomy; eight were cross-sectional studies, two were prospective cohort studies, one was a case-control study, and one was a randomized controlled trial. Overall

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Lipid profiles and hypertension

By | August 17, 2000

Hypertension in men is associated with an unfavorable lipid profile.

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Maternal age

August 17, 2000

NEW YORK, Aug 14 (Praxis Press) Advancing maternal age has been linked to a child's subsequent risk of type 1 diabetes, but most studies have not used genetically related siblings. Bingley and colleagues studied the interactive effects of parental age and birth order on childhood development of type 1 diabetes in a cohort of 1,375 families with at least one diabetic child. The risk of diabetes in offspring increased by 25% and 9% for each 5-year increment in maternal and paternal age, respecti

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NEW YORK, August 16 (Praxis Press). Preterm birth is defined as birth before 37 gestational weeks. Although infants born at 32 through 36 weeks are more common than very preterm infants (those born before 32 weeks), most studies have focused on very preterm infants because of their high risk of mortality and serious morbidity. In a new study, Kramer and colleagues examined the contribution of mild (birth between 34 and 36 weeks) and moderate (birth between 32 and 33 weeks) preterm birth to infan

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Oral insulin

August 17, 2000

Oral insulin administration does not preserve beta-cell function in patients with newly diagnosed type 1 diabetes.

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