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New line of research on cocaine addiction

By | June 1, 2001

A new study suggests that a single dose of cocaine primes the brain for addiction.

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Shear forces promote lymphocyte migration

By | June 1, 2001

Continuous force or shear stress from fast flowing fluid must be applied on adherent white blood cells to facilitate migration across endothelium.

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ssDNA Tools

By | June 1, 2001

Single-stranded oligonucleotides may provide a new tool for homologous recombination and genome modification.

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Statins can block inflammation

By | June 1, 2001

LFA703, a statin with high binding affinity for the LFA-1 site but low activity against HMG-CoA reductase has increased anti-inflammatory effects.

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Training microarrays

By | June 1, 2001

Artificial neural networks can help in applying microarray data to tumour diagnosis.

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Complementary medicine under scrutiny

By | May 31, 2001

The establishment of a new research centre for complementary medicine at Harvard Medical School signals a growing interest in subjecting complementary therapies to scientific scrutiny.

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Error-prone polymerases make efficient immunity

By | May 31, 2001

the process behind increasing antibody affinities after multiple exposures to the same antigen.

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How retinoids kill leukaemic cells

By | May 31, 2001

Retinoid hormones can induce post-maturation apoptosis through the Apo-2L/TRAIL death ligand.

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Influencing influenza

By | May 31, 2001

Serial passaging in mouse lungs selects for virulent variants of influenza A virus that result from several mutations.

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DNase II and erythropoiesis

By | May 29, 2001

Deoxyribonuclease II (DNase II) is a lysosomal DNase that has been implicated in the degradation of DNA in apoptotic cells. In the May 25 Science, Kawane et al. report the analysis of mice lacking a functional DNase II protein (Science 2001, 292:1546-1549). No DNase II-null mice survived until birth. Mutant embryos developed anemia at embryonic days 12.4-14.5 and had dramatically reduced numbers of mature erythrocytes. Transplantation of DNase II-null fetal liver cells into irradiated mice gener

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