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Mannose binding lectin gene influences severity of liver disease

By | May 22, 2001

An independent genetic factor, the mannose binding lectin gene influences liver disease severity in cystic fibrosis patients.

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Painting the fourth

By | May 22, 2001

Chromosome 4 of Drosophila melanogaster is an atypical autosome, exhibiting several features characteristic of the X chromosome. In the May 22 Proceedings of the National Academy of Sciences, Larsson et al. report the molecular cloning of Painting of fourth (Pof), which encodes a protein that specifically paints chromosome 4 (Proc Natl Acad Sci USA 2001, 98:6273-6278). The POF protein sequence contains a putative RNA-binding domain. POF protein decorates chromosome 4 by spreading out from an ini

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Lively lipids

By | May 21, 2001

In the May 18 Science, Farber et al. report the use of fluorescently quenched phospholipid substrates to screen for genes affecting lipid metabolism in living zebrafish larvae (Science 2001, 292:1385-1388). The lipids were swallowed by the larvae and cleaved by lipases in the intestine before the fluorescent metabolites were transported to the liver and gall bladder. The assay demonstrated lipid metabolism defects in zebrafish mutants that have abnormal digestive organ morphology, as well as the

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Macrophage inflammatory protein inhibits HIV replication

By | May 21, 2001

has only weak antiviral activity.

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New malaria center for Johns Hopkins

By | May 21, 2001

Malaria research has been underfunded for decades. Now, a $100 million donation to Johns Hopkins University should allow much-needed progress on vaccines.

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Prohibitin genotyping as breast cancer indicator

By | May 21, 2001

The 3' untranslated region of the prohibitin gene encodes an RNA molecule that arrests cell proliferation when injected into breast cancer cell lines. A single point mutation in this region creates a variant T allele that lacks the antiproliferative activity of the more common functional C allele. In May 19 Lancet, Eldon Jupe and colleagues from Oklahoma Medical Research Foundation, Oklahoma City present evidence that women carrying the prohibitin T allele have increased susceptibility to breast

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Bugs in the genome

By | May 18, 2001

Comparative proteome analysis identifies just 40 genes that are candidates for lateral transfer from bacteria to vertebrates.

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Emotional stimuli

By | May 18, 2001

The amygdala enhances our perception of stimuli that have emotional significance.

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No link between mumps and inflammatory bowel disease

By | May 18, 2001

Mumps virus DNA could not be detected in intestinal specimens or peripheral blood lymphocytes from patients with inflammatory bowel disease.

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Nottingham's smoking gun

By | May 18, 2001

Editor from his post at Nottingham University inprotest at tobacco industry funding has ignited a fierce debate over ethicsand impartiality in medical research.

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