The largely overlooked resident fungal community plays a critical role in human health and disease.
April 3, 2001|
Bloom syndrome is a disease characterized by increased tumorigenesis, immunodeficiency and partial sterility. It is caused by mutations in the BLM gene, which encodes a helicase. In the March 30th Science, Kusano et al. describe characterization of the Drosophila Dmblm homolog of BLM (Science 2001, 291:2600-2602). They show that Dmblm corresponds to mus309, which was originally identified in a mutagen-sensitivity screen. Disrupting the Dmblm gene causes mutagen sensitivity and female sterility,