News & Opinion

Covering the life sciences inside and out

Most Recent

Mono-allelic expression in trypanosomes

By | December 17, 2001

The parasite Trypanosoma brucei can exploit antigenic variation of its VSG coat proteins to avoid detection by the mammalian host. In the December 13 Nature, Miguel Navarro and Keith Gull from the University of Manchester, UK, provide a mechanism for mono-allelic VSG expression (Nature 2001, 409:759-763).They investigated the role of RNA polymerase I (pol I) and nuclear compartmentalization in VSG expression. They used antibodies against T. brucei pol I, to identify a 'pol I body' outside the nu

0 Comments

Neuroglobin protection in brain ischaemia

By | December 17, 2001

Ischaemic injury can prompt increased neuroglobin production and a reduction in hypoxia.

0 Comments

Rewiring the brain

By | December 17, 2001

Injuries of eye lenses can induce significant axonal regeneration of the optic nerve.

0 Comments

Double mutations

By | December 14, 2001

The vast majority of genes in the yeast genome are non-essential suggesting significant functional redundancy. In the December 14 Science, Amy Tong and colleagues describe an approach for high-throughput synthetic-lethal analysis in yeast (Science 2001, 294:2364-2368).They developed an ordered array of about 4,700 viable gene-deletion mutants and generated haploid double-mutants; they called this strategy synthetic genetic array (SGA) analysis. Tong et al. tested a query strain with a deletion i

0 Comments

In control of body size

By | December 14, 2001

The proto-oncogene c-Myc has been implicated in the genesis of many different types of tumors, but its role in normal physiology remains unclear. In December 13 Nature, Andreas Trumpp and colleagues from University of California at San Francisco show that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size.Trumpp et al. generated an allelic series of mice in which c-Myc expression was incremen

0 Comments

Wellcome Trust buys Crick's archives

By | December 14, 2001

The Wellcome Trust and Heritage Lottery Fund combine to secure open access to Francis Crick's papers.

0 Comments

Mast cell survival gene

By | December 13, 2001

RI-induced mast cell survival, but has no obvious role in mast cell development.

0 Comments

Telomere capping

By | December 13, 2001

Telomeres protect the ends of chromosomes and prevent chromosomal end-to-end fusions. The DNA-dependent protein kinase (DNA-PK) has been implicated in DNA repair and telomere maintenance. In the December 18 Proceedings of the National Academy of Sciences, David Gilley and colleagues at the Lawrence Berkeley National Laboratory report the use of knockout mice to examine the function of the DNA-PK catalytic subunit (Proc Natl Acad Sci USA 2001, 98:15084-15088).Analysis of fibroblast and primary cu

0 Comments

Bugs in flies

By | December 12, 2001

The mechanisms underlying the innate immune system are highly conserved from flies to mammals. In the December 18 Proceedings of the National Academy of Sciences, Phil Irving and colleagues describe a genome-wide screen for genes induced in Drosophila following infection with bacteria or fungi (Proc Natl Acad Sci USA 2001, 98:15119-15124).They performed oligonucleotide-array gene-profiling analysis on material from flies inoculated with Gram-negative or Gram-positive bacteria or with the fungi B

0 Comments

T-cell loss in HIV explained

By | December 12, 2001

not a decrease in T cell production.

0 Comments

Popular Now

  1. Publishers’ Legal Action Advances Against Sci-Hub
  2. Metabolomics Data Under Scrutiny
    Daily News Metabolomics Data Under Scrutiny

    Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.

  3. How Microbes May Influence Our Behavior
  4. Decoding the Tripping Brain
AAAS