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Stem-cell genomics

By | July 6, 2001

The surprising plasticity and trans-differentiation of transplanted stem-cells suggest that there may be a set of universal stem-cell genes that govern the undifferentiated proliferative state. In the July 3 Proceedings of the National Academy of Sciences, Terskikh et al. report attempts to define a common stem-cell gene profile by comparing hematopoietic and neural stem-cells (Proc Natl Acad Sci USA 2001, 98:7934-7939). They isolated hematopoietic stem cells (HSC) from mouse bone marrow and cre

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Sweet success of immunomodulatory therapy

By | July 6, 2001

expression combined with re-education of newly emerging T cells with self antigens can reverse established autoimmune diabetes in mice.

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Systems biology research centre to be built in Singapore

By | July 6, 2001

A new research centre is being established in Singapore that will use a multidisciplinary approach to study systems biology.

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Hippocampus arrays

By | July 5, 2001

The hippocampus plays a role in the brain's ability to learn and remember. In the Early Edition of the Proceedings of the National Academy of Sciences, Mody et al. report the use of a microarray strategy to define genes involved in the development and function of the mouse hippocampus. They used Affymetrix oligonucleotide arrays to screen for the expression profiles of 11,000 genes in embryonic (E16) or postnatal (P1, P7, P16 and P30) mouse hippocampus tissue. They found that 1,926 genes showed

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Caught by the secretory-trap

By | July 4, 2001

The gene-trap strategy can exploit insertional mutagenesis to allow phenotypic screening. In the July issue of Nature Genetics, Mitchell et al. demonstrate the power of gene-trap mutagenesis for genome-wide analysis of the genes involved in mouse development (Nature Genetics 2001, 298:241-24). Their modified 'secretory-trap' vector selects genes that have secretory signal sequences or transmembrane domains. Screening over 500 insertions in mouse embryonic stem (ES) cells identified 187 individua

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The Royal Society Summer Exhibition 2001

By | July 4, 2001

The scientific equivalent of the Royal Academy's Summer Exhibition is underway at Carlton Gardens with over 20 fascinating topics to choose from.

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Deadly fusion

By | July 3, 2001

Translocations in acute megakaryoblastic leukemia result in the fusion of two novel genes.

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Nicotine promotes tumour growth and atherosclerosis

By | July 3, 2001

Treatment for nicotine addiction may be as harmful as smoking, as nicotine seems to promote angiogenesis and tumour formation.

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Degrading mutations

By | July 2, 2001

Mutations in matrix metalloproteases have been detected in inherited osteolytic and arthritic disorder.

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Minor histocompatibility antigen has anti-leukaemic role

By | July 2, 2001

have curative anti-leukaemia activity through a graft-versus-leukaemia effect with no graft-versus-host disease.

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