Advertisement

News & Opinion

Covering the life sciences inside and out

Most Recent

Hearts on night shift

October 19, 2000

Rigid circadian rhythms could explain the high incidence of heart disease among shift workers.

0 Comments

re

October 19, 2000

Researchers have found a link between sight and sound that could improve awareness of neurological disorders.

0 Comments

SNP genotyping with arrays

By | October 19, 2000

Single nucleotide polymorphisms (SNPs) are sequence variants in which two alternate bases occur at one position. The SNP Consortium is developing a dense map of SNPs in the hope that certain variants can be associated with disease states. With hundreds of thousands of SNPs identified, the scoring of these SNPs in patient populations has become the limiting factor. Hirschhorn et al. provide a possible solution in the October 24 Proceedings of the National Academy of Sciences by making the existin

0 Comments

Very old bugs

By | October 19, 2000

In the 19 October Nature Vreeland et al. report that the longevity record for bacteria has been smashed (Nature 2000, 407:897-900). The previous record holder was a Bacillus identified from the abdominal contents of a bee preserved in amber some 25 to 40 million years ago. The newly identified bacterium is also a Bacillus, but comes from a brine inclusion within a 250 million-year-old salt crystal. The crystal was found 569m below the surface, in the wall of an air-intake shaft of a waste isolat

0 Comments

Daughters keep to themselves

By | October 18, 2000

In the 13 October Science Takizawa et al. use array analysis to identify a transmembrane protein that, combined with a septin barrier, may keep proteins in the daughter cells of budding yeast (Science 2000, 290:341-344). The messenger RNA for transcription factor Ash1p is already known to be transported to the bud tip of the daughter yeast cell by an actomyosin system; once the protein is translated in the daughter cell it represses mating-type switching. Takizawa et al. look for other transport

0 Comments

Defining relevance

By | October 18, 2000

In the October 24 Proceedings of the National Academy of Sciences Butte et al. propose that relevance networks could provide a better way of analyzing genomic information than phylogenetic trees (Proc Natl Acad Sci USA 2000, 97, published online ahead of print). Phylogenetic trees derived from array experiments can only link a gene to one other gene, typically the one that is most strongly correlated in its expression pattern. In contrast, the method presented by Butte et al. can group any numbe

0 Comments

Mapping recombination

By | October 18, 2000

In the October 10 Proceedings of the National Academy of Sciences Gerton et al. use arrays to map hotspots and coldspots of meiotic recombination across the whole yeast genome (Proc Natl Acad Sci USA 2000, 97:11383-11390). They isolate DNA from sporulating cells that are mutant in rad50S, and therefore blocked with the recombination protein Spo11p covalently bound to DNA. The DNA fragments that are covalently linked to proteins (with Spo11p presumably predominant) are trapped using a glass filte

0 Comments

Could selfish DNA create new proteins?

By | October 17, 2000

Selfish DNA may help to expand protein sequences, based on the discovery of DNA repeats inserted, in-frame, into 19 genes of an intracellular bacterium.

0 Comments

Many ways to be minimal

By | October 17, 2000

The genome of Mycoplasma genitalium is so far the smallest discovered for any free-living organism, so it has been used as a starting point for defining a minimal genome. Transposon mutagenesis and comparison with a second mycoplasma have further narrowed down the list of genes. Now Glass et al. announce the sequencing of a third mycoplasma, the mucosal pathogen Ureaplasma urealyticum, in the 12 October Nature (Nature 2000, 407:757-762). Their results suggest that there is more than one version

0 Comments

A leading cancer trial specialist warns that over-complexity of trials could be delaying the process by which successful drugs reach patients. Professor Richard Gray, Director of the Clinical Trials Unit at the University of Birmingham, voiced his concerns at the European Society for Medical Oncology conference. He called for a move towards simpler and more direct planning and organisation of trials.Currently, trials involve a great demand on patients to undergo extra investigations and attend f

0 Comments

Follow The Scientist

icon-facebook icon-linkedin icon-twitter icon-vimeo icon-youtube
Advertisement

Stay Connected with The Scientist

  • icon-facebook The Scientist Magazine
  • icon-facebook The Scientist Careers
  • icon-facebook Neuroscience Research Techniques
  • icon-facebook Genetic Research Techniques
  • icon-facebook Cell Culture Techniques
  • icon-facebook Microbiology and Immunology
  • icon-facebook Cancer Research and Technology
  • icon-facebook Stem Cell and Regenerative Science
Advertisement
Rainin Instrument
Rainin Instrument
Advertisement
PITTCON
PITTCON
Life Technologies