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VEGF gene achieves angiogenesis

By | August 30, 2000

Vascular Endothelial Growth Factor restores blood flow to areas of cardiac tissue previously hibernating.

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NEW YORK, Aug 28 (Praxis Press). Despite similar degrees of airflow obstruction, patients with past or present asthma, either with or without chronic obstructive pulmonary disease (COPD), walk more slowly than patients with COPD. Laszlo and colleagues studied twelve-minute walking speed (hurrying) and lung function in twenty-four patients with COPD, ten patients with asthma, four patients with both COPD and asthma, and eighteen healthy controls. Most of the difference (70%) in walking speeds bet

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Anemia and pregnancy

August 29, 2000

Iron deficiency in women considering pregnancy should be corrected.

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Estrogen and cognition

August 29, 2000

Free and unbound estrogen could protect older women from cognitive decline.

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NIH issues US embryonic stem cell guidelines, at last

By | August 29, 2000

But November's presidential election is likely to determine whether US scientists will ever be able to do this work with taxpayer blessings - and money.

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NEW YORK, Aug 28 (Praxis Press). Despite immunosuppressive and other therapies, the annual mortality rate of systemic lupus erythematosus (SLE) remains about one percent. Traynor and colleagues studied the effects of high-dose cyclophosphamide treatment and autologous, haematopoietic stem cell transplantation in nine patients with severe, steroid-dependent SLE. Two patients developed infections (cytomegalovirus and mucormycosis) after stem cell harvest and were excluded from the study; seven pat

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Alcoholism treatment

August 25, 2000

NEW YORK, August 25 (Praxis Press). Early-onset alcoholism (before age 25 years) is associated with serotonergic dysfunction, and individuals with early-onset alcoholism may be responsive to treatment with a selective serotonergic agent. To compare the effectiveness of ondansetron, a selective serotonin receptor antagonist, in the treatment of early-onset and late-onset alcoholism, Johnson and colleagues performed a double blind, randomized, placebo-controlled clinical trial. A total of 321 pati

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Early low-fat diet doesn't harm development

By | August 25, 2000

A low-fat, low-cholesterol diet in babies may protect against coronary heart disease in adulthood.

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Estrogen and CHD

August 25, 2000

NEW YORK, August 25 (Praxis Press). Although coronary heart disease (CHD) is a major cause of illness and death in women, the role of estrogen in its treatment and prevention remains unclear. To examine this relationship, Herrington and colleagues randomized a total of 309 women with angiographically verified CHD to receive: 0.625 mg of conjugated estrogen per day; 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate per day; or a placebo. They then followed the women for a

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Genes that provide tumors with blood

By | August 25, 2000

In the 18 August Science St. Croix et al. present an expression analysis of endothelial cells from blood vessels of normal and malignant colorectal tissue (Science 2000, 289:1197-1202). After developing a method for purifying these scarce cells, they use serial analysis of gene expression (SAGE) to identify a host of new pan-endothelial markers that are not expressed in other tissues. Additionally, 46 SAGE tags are elevated tenfold or more specifically in tumor endothelium, and at least 7 of the

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