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Dendritic and T cells keep in touch

By | September 18, 2001

In the absence of antigen, dendritic cells still interact with T cells to induce cytokine gene expression and maintain protective immunity.

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Genomic mountains

By | September 18, 2001

One of the challenges for microarray analysis is making sense of the mountains of data that this technology can generate. In the September 14 Science, Stuart Kim and colleagues from Stanford University show how three-dimensional maps can be used to navigate microarray data (Science 2001, 293:2087-2092).They established a compendium of gene expression profiles for the Caenorhabditis elegans genome using data from 553 microarray experiments. They created topological maps in which distance defines

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Leeches give bite to arthritis care

By | September 18, 2001

The once-reviled leech, recently lauded for its potential in preventing repeat heart attacks, could also have a role to play in the treatment of pain and inflammation. In the October Annals of the Rheumatic Diseases Gustav Dobos and colleagues at the Essen-Mitte Clinic, Germany, used leech therapy to treat a number of patients with chronic arthritis (Ann Rheum Dis 2001, 60:986).They studied 16 patients with an average age of 68 years who had suffered persistent knee pain for more than six months

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Neural stem transplant may stir gut wall

By | September 18, 2001

Neural stem cells survive within the pyloric wall following transplantation, possibly by responding to the enteric neurotrophin GDNF.

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GM corn field studies endorse safety

By | September 17, 2001

derived toxins has a negligible impact on monarch larvae populations.

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New era for the European Bioinformatics Institute

By | September 17, 2001

Janet Thornton takes over as head of the EBI and outlines her vision of the development of the field of bioinformatics.

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Predictable

By | September 17, 2001

If clinicians could predict how a cancer patient would respond to specific chemotherapeutic drugs, they would be able to choose an individualized treatment protocol with greater chances of success and minimized side effects. In the September 11 Proceedings of the National Academy of Sciences, Jane Staunton and colleagues from the Whitehead Institute, Cambridge, Massachusetts describe a genomic approach for predicting chemosensitivity (Proc Natl Acad Sci USA 2001, 98:10787-10792).They measured th

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The 2001 Lasker Award Winners announced

By | September 17, 2001

The Albert Lasker Award for Basic Medical Research has been awarded to Mario Capecchi, Martin Evans and Oliver Smithies.

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New adhesion mechanism in sickle cell disease

By | September 14, 2001

The characteristic pain crises and organ failure seen in sickle cell disease results from the abnormal red blood cells adhesion to the endothelium of small vessels and subsequent blood flow cessation. In September 15 Blood, Neil Matsui and colleagues from University of California at San Francisco describe a new cell adhesion mechanism involving the P-selectin molecule that could lead to improved treatments for sickle cell disease.P-selectin is an adhesion protein present on activated endothelial

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New key glucose factory controller

By | September 14, 2001

Despite the knowledge on insulin, the molecular mechanisms in the liver that maintain blood glucose levels within tight limits are not fully understood. Two papers in September 13 Nature show that the transcriptional coactivator PGC-1 is a key molecule in the mechanism of liver glucose response to fasting and suggest that this pathway may be defective in type 1 and type 2 diabetes.Yoon and colleagues from Dana-Farber Cancer Center, Harvard Medical School, Boston, Massachusetts found that PGC-1 i

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