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April 4, 2001|
The thymus prevents autoimmunity by inducing apoptosis of the T cells that express autoreactive receptors to self peptides. But this mechanism alone is insufficient and CD4+CD25+ regulatory T cells are selected in the thymus to control autoreactive thymic escapees. In the April Nature Immunology, researchers from The Wistar Institute, Philadelphia, describe a novel mechanism of thymic selection that is involved in the generation of CD4+CD25+ regulatory T cells.Using a murine model, Jordan et al