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Adrenergic signalling affects progression of cardiomyopathy

By | April 19, 2001

-adrenergic receptor signalling or excitation-contraction coupling can prevent systolic dysfunction, exercise intolerance and cardiac remodelling.

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AIDS drugs manufacturers drop case

By | April 19, 2001

Today 39 pharmaceutical companies unconditionally dropped their case against the South African government. A turning point in the case may have been persuasive evidence that the companies have no economic basis for the huge prices they charge for AIDS drugs.

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locus

By | April 19, 2001

The importance of the INK4A/CDKN2A locus, encoding the p16/INK4a and p19/ARF proteins, in tumor suppression is underscored by the high frequency of mutation or silencing of the locus in human tumors. In the April 24 Proceedings of the National Academy of Sciences, Magdinier and Wolffe describe the role of the methyl-CpG binding protein MBD2 in INK4a/ARF gene repression in cancer cells (Proc Natl Acad Sci USA 2001, 98:4990-4995). They used chromatin immunoprecipitation (ChIP) experiments to study

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After the (draft) sequence

By | April 18, 2001

Now that the dust has settled after publication of the human genome sequence, Sydney Brenner assesses the first draft.

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Fibroblast clocks

By | April 18, 2001

Mammalian circadian clocks are regulated by a series of interacting positive and negative transcription-translation feedback loops in the hypothalamic suprachiasmatic nucleus (SCN). In the April 13 Science, Yagita et al. describe an in vitro model system that resembles the molecular oscillator in the SCN (Science 2001, 292:278-281). Cultured fibroblasts exhibit cycling circadian gene expression when stimulated with the vasocontracting peptide endothelin-1. Endothelin-1 induced cycling phases of

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Gastric trefoil peptides work on the night shift

By | April 18, 2001

Trefoil peptide TFF2 secretion has a circadian rhythm with highest concentrations detected during the night sleep, suggesting repair of gastric mucosa occurs at this time.

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genome exposed

By | April 18, 2001

contains 1,752 predicted protein-encoding genes, more than 40 of them identified as putative virulence-associated genes.

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Form of cholesterol 'pivotal' in heart disease

By | April 17, 2001

Blood levels of a specific form of cholesterol are directly related to the severity of heart disease.

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Hypervirulent knockout

By | April 17, 2001

Most studies of parasite virulence have focused on identifying genes whose loss causes decreased virulence or infectivity. In the April 13 Science, Cunningham et al. report the characterization of two genes in the protozoan parasite Leishmania, mutation of which causes hypervirulence (Science 2001, 292:285-287). Stephen Beverley and colleagues at Washington University demonstrate that Leishmania mutants lacking the genes for pteridine reductase 1 (PTR1) or biopterin transporter BT1 exhibit incre

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Is a toxic gas protecting the liver?

By | April 17, 2001

The liver is the primary organ involved in heme detoxification under disease conditions, but its self-protective mechanisms against toxic compounds are unknown. In the April Gastroenterology Takanori Kyokane and colleagues from Nagoya University School of Medicine, Nagoya, suggest that carbon monoxide (CO), the gaseous product of heme oxygenase (HO), may have a protective role against hepatobiliary dysfunction caused by heme overloading under sepsis and stress conditions.Kyokane et al perfused l

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