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Headache and heart disease

September 19, 2000

Some patients with episodic headaches could have myocardial ischemia.

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Interfering nonsense

By | September 18, 2000

Worm proteins required for nonsense-mediated mRNA decay are also required for maintenance of RNA interference.

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Lasker Awards presented for work on ubiquitination and hepatitis C

By | September 18, 2000

The 2000 Albert Lasker Medical Research Awards, announced in New York on September 17, will put further pressure on the Nobel Foundation to grant a Nobel Prize for work related to the cell cycle.

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Race relations gone cuckoo

By | September 18, 2000

Cuckoos lay eggs that mimic the eggs of other bird species; those eggs are then looked after by the unsuspecting foster parent. Cuckoos have been divided into races based on the identity of the egg type that the females mimic. In the 14 September Nature Gibbs et al. report that only female cuckoos observe 'race' boundaries (Nature 2000, 407:183-186). Mitochondrial DNA, which is passed solely through the female line, occurs in race-specific haplotypes. But nuclear DNA, which segregates through bo

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Cytokine gene regulation by NFAT

By | September 15, 2000

Point mutations in the transcription factor NFAT define sets of cytokine genes whose regulation is dependent on or independent of cooperation between NFAT and Fos/Jun

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Recognizing Mom's scent

By | September 15, 2000

Proteins of the major histocompatibility complex (MHC) are involved in cell-cell recognition: they bind and present antigens in the immune system. But, at least in mice, they are also involved in odor-based recognition between individuals. Mice tend to mate with MHC-dissimilar mice (to maintain MHC diversity) and nest with MHC-similar mice. In the September 12 Proceedings of the National Academy of Sciences Yamazaki et al. report that mothers recognize and preferentially retrieve MHC-similar pup

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The first photosynthesis was purple

By | September 15, 2000

Molecular phylogenies of bacteria are mostly built on the analysis of conserved molecules such as 16S ribosomal RNA. But there is evidence for horizontal gene transfer of photosynthesis genes, so any debate about the origin of photosynthesis must look directly at the evolution of that gene group, independent of its bacterial host. This is what Xiong et al. undertake in the September 8 Science, using 100 kb of newly generated sequence that identifies many genes for photosynthetic pigment synthesi

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vCJD could be transmitted through blood transfusions

By | September 15, 2000

A study in sheep shows that BSE can be transmitted between individuals of the same species by whole blood transfusion.

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Evidence that teaching hospitals have better survival outcomes

By | September 14, 2000

Quality of care for acute MI patients is better in teaching hospitals, perhaps because they practice evidence-based medicine.

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Stem cell transplant shrinks tumour metastases

By | September 14, 2000

LONDON, 14 September (SPIS MedWire). Stem cell transplantation may offer hope to patients with advanced kidney cancer - usually considered an incurable illness. According to a report in today's New England Journal of Medicine, 19 patients with metastatic renal cell carcinoma, which had not responded to conventional therapy, received low-dose chemotherapy and immunosuppression followed by stem cell transplantation from a related donor. In seven patients there was shrinkage of metastases, and thre

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