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Covering the life sciences inside and out

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Oxygen transport rate linked to plasma cholesterol levels

By | December 5, 2000

Measurements of the oxygen transport rate could provide an alternative to cardiac stress tests.

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Banking on genes

By | December 4, 2000

Various high-profile genetic projects around the world are pushing the barriers of research. But are they trespassing on human rights?

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Everything binds everything

By | December 4, 2000

In the December Nature Biotechnology Schwikowski et al. combine the large-scale two-hybrid analyses of Uetz et al. and Ito et al. with other published two-hybrid results to come up with a total of 2,709 interactions encompassing 2,039 different yeast proteins. The synthesis of these results yields a single large network of 2,358 interactions among 1,548 yeast proteins, with the next largest network containing only 19 proteins (Nat Biotechnol 2000, 18:1257-1261). Connections between proteins assi

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Protecting plants

By | December 4, 2000

Plants that recognize a pathogen induce both a local defense response and a long-lasting, broad spectrum disease resistance throughout the plant, termed systemic acquired resistance (SAR). In the December Nature Genetics Maleck et al. use microarrays to monitor transcriptional changes during development of SAR (Nat Genet 2000, 26:403-410). Of the 10,000 expressed sequence tags (ESTs) on the microarrays, representing 25-30% of all genes from Arabidopsis thaliana, 413 show changes of 2.5-fold or m

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Acute coronary events more likely at beginning of menstrual cycle

By | December 1, 2000

Almost three-quarters of acute cardiac events in premenopausal women occur between days one and five of the menstrual cycle.

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Patients with Down's syndrome can still feel the pain

By | December 1, 2000

Individuals with Down's syndrome feel pain, even though they react to it more slowly.

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Caught in the act

By | November 30, 2000

In the 30 November Nature, Kopp et al. report that altered regulation of the bric-a-brac (bab) gene drove the evolution of sexually dimorphic pigmentation in Drosophila (Nature 2000, 408:553-559). The fifth and sixth abdominal segments (A5 and A6) of male Drosophila melanogaster are fully pigmented, whereas those of the female or of males of many other Drosophila species are only partially pigmented. The D. melanogaster males discriminate strongly against females with extra pigmentation, so the

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Neural transplantation for Huntington's disease

By | November 30, 2000

Transplanted foetal neurons can improve human brain activity in patients with Huntington's disease.

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Potential vaccine for Ebola virus

By | November 30, 2000

A vaccine that protects monkeys against Ebola virus has been developed but there's still some way to go before a human version is available.

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Searching for nuclear localization signals

By | November 30, 2000

Nuclear localization signals (NLSs) are motifs that mediate the transport of proteins to the nucleus, but finding an NLS within your protein of interest can be tricky. In the 15 November EMBO Reports (EMBO Reports 2000, 1:411-415), Cokol et al. describe an 'expert database' of NLSs, created by collecting 91 experimentally determined NLSs and extending the dataset by 'in silico mutagenesis'. They initially increased the database by adding homologous proteins, and then analyzed sets of proteins wi

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Thermo Scientific

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