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Budding interactome

By | March 15, 2001

Functional genomics aims to turn genomic information into a comprehensive understanding of the workings of the cell at the molecular level. It is assumed that extensive knowledge of the interactions between proteins will contribute significantly to this goal. In the Early Edition of Proceedings of the National Academy of Sciences, Ito et al. describe the results of a comprehensive high-throughput screen to identify all the protein-protein interactions (the 'interactome') in the budding yeast S

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Enterococcus faecium

By | March 15, 2001

Vancomycin-resistant Enterococcus faecium (VREF) causes an infection common in US hospitals and is resistant to all commercially available antibiotics. Hospital outbreaks are rare in Europe, although VREF carriage among healthy individuals and livestock is common. A study from the National Institute of Public Health, Bilthoven, Netherlands, published in the online version of the Lancet on 13 March, suggests that genetic screening of E. faecium carriers could help eradicate this infection (Lancet

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Structure of a biological propeller

By | March 15, 2001

explains how bacteria can switch between 'running' and 'tumbling' motions.

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Caretakers and gatekeepers

By | March 14, 2001

Cellular gatekeepers include the proteins that regulate cell cycle progression in response to DNA damage, and the DNA repair pathways function as genomic caretakers. The p53 and ATM (ataxia-telangiectasia-mutated) proteins behave as cellular gatekeepers, whereas the non-homologous end-joining (NHEJ) DNA repair machinery acts as a genomic caretaker. NHEJ factors include Ku70, Ku80 and the DNA-PK enzyme, plus XXRC4 and DNA Ligase IV (Lig4), which function in ligation.In 6 March Proceedings of the

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Multiprotein DNA/MVA vaccine for AIDS

By | March 14, 2001

DNA priming followed by a recombinant modified vaccinia Ankara (rMVA) booster has controlled a highly pathogenic immunodeficiency virus challenge in a rhesus macaque model.

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Neuron survival is not enough

By | March 14, 2001

Parkinson's disease is associated with the loss of dopamine neurons in the caudate and putamen nuclei of the brain. Several groups have tried to slow down the neuron loss by transplanting embryonic precursors of dopaminergic cells and obtained some promising results. In the 8 March issue of New England Journal of Medicine a team from University of Colorado School of Medicine, Denver, published the first double-blind placebo controlled study of the transplant therapy (N Engl J Med 2001, 344:710-7

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Genes controlling longevity

By | March 13, 2001

A gene that controls lifespan in yeast also regulates longevity in nematode worms.

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More data indicate no link between MMR and autism

By | March 13, 2001

1994, but this does not correlate with a small relative increase in the MMR immunization rate.

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Pasteur's genome

By | March 13, 2001

Pasteurella multocida causes disease in birds, cattle, swine and humans, but the mechanisms underlying its virulence are unknown. In the 6 March PNAS May and colleagues report the complete sequence of the Pasteurella multocida (Pm70) genome (PNAS 2001, 98:3460-3465).May et al used a shotgun strategy to sequence more than 53,000 DNA fragments and assemble them into a single circular sequence of about 2.26 Mb. The Pm70 genome contains 2,014 predicted coding regions, accounting for 89% of the entir

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Insulin resistance linked to CD36 deficiency

By | March 12, 2001

Insulin resistance is mainly characteristic for type 2 diabetes, a common disorder that is also a potent risk factor for coronary heart disease. Genetic associations with type 2 diabetes have recently been drawn, and genes underlying rare monogenic causes of insulin resistance have been identified. But the molecular basis of the common insulin resistance remains unknown.In 3 March Lancet, Koji Miyaoka and colleagues from Osaka University, Japan present evidence for insulin resistance in CD36-def

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