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Estrogen and CHD

August 25, 2000

NEW YORK, August 25 (Praxis Press). Although coronary heart disease (CHD) is a major cause of illness and death in women, the role of estrogen in its treatment and prevention remains unclear. To examine this relationship, Herrington and colleagues randomized a total of 309 women with angiographically verified CHD to receive: 0.625 mg of conjugated estrogen per day; 0.625 mg of conjugated estrogen plus 2.5 mg of medroxyprogesterone acetate per day; or a placebo. They then followed the women for a

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Genes that provide tumors with blood

By | August 25, 2000

In the 18 August Science St. Croix et al. present an expression analysis of endothelial cells from blood vessels of normal and malignant colorectal tissue (Science 2000, 289:1197-1202). After developing a method for purifying these scarce cells, they use serial analysis of gene expression (SAGE) to identify a host of new pan-endothelial markers that are not expressed in other tissues. Additionally, 46 SAGE tags are elevated tenfold or more specifically in tumor endothelium, and at least 7 of the

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Link found between proteins responsible for Alzheimer's and vCJD

By | August 25, 2000

A Chinese research team has described a 'striking similarity' between the proteins involved in the early stages of Alzheimer's disease and variant Creutzfeldt-Jakob disease.

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Malaria should shiver at a new attack to be mounted against the disease.

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Persistent bacterial infection and vascular disease

By | August 25, 2000

Autoimmune reaction to infection could be an important factor in atherogenesis.

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Abortion

August 24, 2000

NEW YORK, August 22 (Praxis Press). Studies have disagreed about the mental health risks associated with elective abortion, but few studies have followed women for long periods of time after abortion or have differentiated between negative emotions and clinically significant psychological distress. Major and colleagues prospectively evaluated emotions, attitudes, and mental health status in 442 women undergoing elective, first-trimester abortion. Two years after the abortion, the majority of wom

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Cytomegalovirus

August 24, 2000

NEW YORK, August 21 (Praxis Press). Ganciclovir prophylaxis is often prescribed in transplantation centers when solid-organ recipients or donors are seropositive for cytomegalovirus (CMV); widespread use of this drug in these immunosuppressed patients has raised concern about the emergence of ganciclovir-resistant CMV. Limaye and colleagues evaluated antiviral susceptibility in 25 of 240 patients who received liver, kidney, or pancreas transplants and who subsequently developed CMV disease. Twen

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HIV shedding

August 24, 2000

NEW YORK, August 18 (Praxis Press). The sexual transmission of HIV is a public health concern, and antiretroviral therapy has been shown in clinical trials to reduce the shedding of HIV in semen. Extending this research to the community setting, Barroso and colleagues studied the effects of antiretroviral therapy on viral shedding in semen in 93 HIV-infected men. Before antiretroviral therapy, HIV RNA was detected in 96% of blood samples and 74% of semen samples; after 6 months of therapy, HIV R

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Homeopathy

August 24, 2000

NEW YORK, August 21 (Praxis Press). Studies have suggested that homeopathic remedies improve symptoms in people with allergies, but controversy persists about the possible role of a placebo effect. Taylor and colleagues compared symptoms in 51 patients with perennial allergic rhinitis randomized to an oral, 30c dilution of a homeopathic preparation of their principal inhalant allergen or to a placebo. Over four weeks of treatment, nasal airflow improved up to 21% in patients taking the homeopath

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Nanodecoys could provide additional protection against viruses

By | August 24, 2000

Decoy cells that are able to keep viruses away from human cells could help prevent infection.

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