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Stenting and fibrinolysis

By | August 14, 2000

Stenting plus abciximab gives better clinical outcome than thrombolysis after acute MI.

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A polymerase for sister chromatid cohesion

By | August 10, 2000

Cohesins , the proteins that are thought to anchor sister chromatids to one another before anaphase, must be present during DNA replication if cohesion is to be established. In the 4 August Science Wang et al . provide a possible link between replication and cohesion (Science 2000, 289 :774-779). They describe an essential DNA polymerase in budding yeast that both has polymerase activity and is required for sister chromatid cohesion. They suggest that the replication fork m

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Hepatitis C

August 10, 2000

NEW YORK, Aug 8 (Praxis Press) Firefighters, emergency medical technicians, and paramedics may be exposed to bloodborne pathogens in their lines of work. In response to concerns about hepatitis C virus (HCV) infection rates among such workers, the Centers for Disease Control evaluated the findings of studies in 4,433 first responders. Data from four major city health organizations and the Department of Public Health and Addiction Services of Connecticut was used. The prevalence of HCV infection

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Many mutant mice

By | August 10, 2000

In the August Nature Genetics , two groups report on their ongoing large-scale projects to produce mouse mutants using the chemical mutagen ethylnitrosourea. An English and French group have screened over 26,000 F1 progeny for dominant defects in growth and development, and a subset of these for defects in neural and behavioral function and blood chemistry (Nolan et al ., Nat. Genet . 2000, 25 :440-443). Their results are cataloged in Mutabase . Approximately half of the

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Melanoma

August 10, 2000

NEW YORK, Aug 8 (Praxis Press) Several patient attributes have been linked with a later stage of melanoma at the time of diagnosis, which in turn confers a poorer prognosis. Van Durme and colleagues studied sociodemographic variables in 1,884 patients diagnosed with melanoma. Regional lymph node or distant metastases were present in 12.9% of patients. A late-stage diagnosis was significantly more likely among patients who were single (odds ratio, 1.5), male (odds ratio, 2.2), smokers (odds ratio

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Smoking and cataracts

August 10, 2000

NEW YORK, Aug 9 (Praxis Press) Although cigarette smoking has been shown to be a risk factor for age-related cataracts, data are inconclusive about the risk of cataracts in individuals who have quit smoking. To examine the association between smoking cessation and the incidence of age-related cataracts, Christen and colleagues performed a prospective cohort study from 1982 through 1997, with an average follow-up time of 13.6 years. The study participants consisted of a total of 20,907 US male ph

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NEW YORK, Aug 9 (Praxis Press) Cigarette smoking is on the rise among adolescents and college students, but little is known about use of non-cigarette tobacco products or cigar use in this population. To assess the prevalence of all forms of tobacco use (cigarettes, cigars, pipes, and smokeless tobacco) among US college students, Rigotti and colleagues surveyed a total of 14,138 randomly selected students. The students were asked to give a self-report of current (in the past 30 days), past year

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HIV-drug abacavir linked to fatal hypersensitivity reactions.

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NEW YORK, August 4 (Praxis Press) Childhood abuse may play a role in the development of mood and anxiety disorders but whether the abuse results in a persistent sensitization or hyperactivity of the corticotropin-releasing factor (CRF) systems is unclear. To investigate this relationship, Heim and colleagues, performed a prospective controlled study of 49 healthy women recruited into four study groups: no current major depression and no history of childhood abuse (controls); current major depres

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NEW YORK, August 3 (Praxis Press) Inhaled corticosteroids are effective in treating asthma but it is unclear whether their use can prevent death from asthma. Suissa and colleagues performed a population-based study of deaths from asthma in Saskatchewan, Canada, between 1975 and 1991, and found that regular use of inhaled corticosteroids might be associated with a decreased risk of death from asthma. Out of 30,569 subjects, 66 patients who died of asthma and who had complete records inhaled a mea

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