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Uncovering the secret to human longevity

By | August 31, 2001

One or more genes on chromosome 4 seem to influence who will live to a ripe old age.

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Viral killer

By | August 31, 2001

The ability to selectively kill cells lacking normal p53 activity is an attractive anti-cancer strategy. In the August 30 Nature, Kenneth Raj and colleagues from the Swiss Institute for Experimental Cancer Research (ISREC) suggest that adeno-associated virus (AAV) could be employed as a 'hired assassin' (Nature 2001, 412:914-917).They found that AAV induced apoptosis of p53-deficient osteosarcoma cells, but induced cell-cycle arrest (in G2 phase) in cells expressing p53. None of the proteins enc

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Not much in common

By | August 30, 2001

A comparison of the Celera and Ensembl transcriptomes examines how many predicted genes they have in common.

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The first tissue specific angiogenic mitogen

By | August 30, 2001

VEGF is a newly identified molecule that is an angiogenic mitogen selective for endocrine gland endothelium.

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An alternative for toll pathway

By | August 29, 2001

Toll-like receptor 4 uses the TIRAP cytoplasmic adapter protein as an alternative route to induce immune responses.

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An oncogene with a split personality

By | August 29, 2001

oncogene could play an important role in the next generation of cancer treatments.

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Cocaine addiction linked to a glutamate receptor

By | August 29, 2001

A previously overlooked glutamate receptor expands our understanding of the neurological basis of learning and addiction.

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Regulating p53

By | August 29, 2001

MDM2 is an E3 ubiquitin ligase that regulates the activity of p53 by controlling degradation of the p53 protein, as a result of differential addition of ubiquitin. In the Advanced Online Publication of Nature Genetics, Parant et al. report the phenotype of mice lacking the recently cloned MDM2-related protein MDM4 (DOI:10.1038/ng714).They show that mdm4-null mice die at embryonic day 7.5-8.5. Analysis of the incorporation of the nucleotide analogue BrdU and TUNEL staining for apoptotic cells sho

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Consequences of patrilocality

By | August 28, 2001

Patrilocality (in which a woman moves to her mate's residence upon marriage) and matrilocality (in which women stay put and the men move) should be reflected in intra- and inter-group differences in the diversity of Y-chromosome and mitochondrial DNA sequences, inherited from the father and mother, respectively. In the Advance Online Publication of Nature Genetics, Oota et al. put this to the test by comparing Y-chromosome and mtDNA diversity in three matrilocal and three patrilocal tribes in no

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DOCK2 controls lymphocyte migration

By | August 28, 2001

The exit of lymphocytes from the vasculature is essential for the control of the inflammatory response. Cell migration involves cytoskeletal dynamics controlled by Rac GTPases but the full molecular mechanism remains unknown. In August 23 Nature, Yoshinori Fukui and colleagues from Kyushu University, Japan, show that DOCK2, a haematopoietic cell-specific protein, mediates cytoskeletal reorganization via Rac activation and is indispensable for lymphocyte chemotaxis.Fukui et al. studied DOCK2-defc

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