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Ulcer healing with local gene therapy

By | November 1, 2001

The mechanism of gastroduodenal ulcer healing involves angiogenesis but the exact roles of molecules such as vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) in this process remain unclear. In November Gastroenterology, Michael Jones and colleagues from University of California, Irvine, California show that gene therapy with a single local injection of naked DNA encoding VEGF and angiopoietin-1 can accelerate ulcer healing.Jones et al. induced ulcers in rats and then injected

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Chemotactic blockbuster

By | October 31, 2001

Dictyostelium discoideum cells display a strong chemotactic response to cyclic adenosine 3',5'-monophosphate (cAMP), mediated by a cell surface receptor and G protein-linked signaling pathway. In October 26 Science, Masahiro Ueda and colleagues from Osaka University, Japan, show the first real-time images of how single fluorescent-labeled cAMP molecules bind to their receptors on living Dictyostelium amoebae.Ueda et al. used an objective-type total internal reflection fluorescence microscope to

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Large libraries

By | October 31, 2001

Libraries containing as many as nine trillion different peptide sequences can be used to select numerous high-affinity RNA-binding peptides.

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Vitamin heart protection role revealed

By | October 31, 2001

Vitamin C could protect against heart disease by reducing apoptosis in vascular epithelial cells.

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Dendritic defence

By | October 30, 2001

Dendritic cells (DCs) are stalwarts of the immune response, activating both the innate and acquired immune systems. In the October 26 Science Qian Huang and colleagues at the Whitehead Institute for Biomedical Research describe the use of oligonucleotide microarrays to examine how DCs respond to different pathogens (Science 2001, 294:870-875).They exposed human monocyte-derived DCs to Gram-negative bacteria (Escherichia coli), fungi (Candida albicans) or an RNA virus (influenza virus), and then

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Fugu genome rough draft completed

By | October 30, 2001

The announcement of the completion of the sequencing of the puffer fish genome will help analysis of the human genome.

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Insurance companies announce genetic testing halt

By | October 30, 2001

A five-year moratorium on the use of genetic test results in the calculation of insurance premiums has provided some much needed breathing space.

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The multifunctional hairless gene

By | October 30, 2001

gene is capable of regulating its own expression, and that of other genes.

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Altered cryopyrin brings fever and chills

By | October 29, 2001

Wells syndromes.

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Chaperones for virulent bacterial proteins

By | October 29, 2001

The type III bacterial chaperones protect the harmful proteins produced by pathogenic bacteria until they are delivered across membranes into the host cell. In October 29 on line Nature Structural Biology, Yu Luo and colleagues from University of British Columbia, Canada report the structures of three type III chaperones, providing important details about the function of the proteins and the mechanisms employed to modulate the virulence of invasive bacteria.Luo et al. reported the crystal struct

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