Bacteria in the intestine influence motor dysfunction and neuroinflammation in a mouse model of Parkinson’s disease.
May 9, 2001|
AMPA-type glutamate synaptic receptors (AMPA-Rs) mediate a wide variety of excitatory synaptic transmissions in the brain. The mechanism by which these receptors maintain a long-term synaptic efficacy are not fully understood. In the 4 May Cell Song-Hai Shi and colleagues at Cold Spring Harbor Laboratory, New York show that AMPA-Rs in hippocampus use a number of delivery mechanisms to stabilize long-term changes in synaptic efficacy.Most hippocamic AMPA-Rs are hetero-oligomers composed of GluR1/