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Cholesterol after CABG

July 6, 2000

New York, July 5, 2000 (Praxis Press) Studies show that a reduction in risk factors following coronary artery bypass surgery (CABG) improves patients' prognosis. Such patient management was suboptimal in Britain before the publication of landmark trials demonstrating the benefit of cholesterol reduction. In a 10-year audit of secondary prevention in CABG patients, Irving et al show that despite significantly improved management of well-established risk factors, including cholesterol concentratio

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Daylight robbery

July 6, 2000

Gustafson et al report in the 29 June Nature that a marine ciliate, Mesodinium rubrum, steals organelles from ingested algae (Nature 2000, 405:1049-1052). Although M. rubrum does not appear to ingest other food, or to maintain permanent symbionts, the ingested organelles help the ciliate to keep photosynthesizing and to maintain a high level of cell division.

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Drawing blood

July 6, 2000

New York, July 5, 2000 (Praxis Press) Blood glucose testing, one of the most commonly performed procedures in clinical practice, traditionally uses lancet sampling drawn from a finger, a procedure experienced as painful by patients. Previous studies suggest the side of the thumb as a less painful site. In an open, prospective randomized trial published by the British Journal of Medicine (see paper), sampling from the earlobe, an equally accessible and vascular site, resulted in a less painful

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The definition of a virus as a DNA or RNA virus, based on its genetic material, is now on shaky ground thanks to the findings of Bresnahan and Shenk in the 30 June Science. Using a gene array, they find that particles of human cytomegalovirus (HCMV), a large DNA virus, contain four different mRNAs (Science 2000, 288:2373-2376). The mRNAs are derived from one immediate-early gene, two early genes and one late gene, but translation from at least one of the packaged mRNAs peaks before there is dete

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"The illegal wildlife trade is the third biggest form of smuggling from Latin America, after the illegal smuggling of drugs and arms" says a Colombian expert. And now genetic material can be "hidden under your nail".

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Long-term response to chronic hepatitis C treatment suggests complete recovery.

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New York, July 5, 2000 (Praxis Press) The 6-month results of the FRISC II (Fast Revascularisation during Instability in Coronary artery disease) invasive trial show a reduction in the composite endpoint of death or myocardial infarction, contradicting previous large-scale randomized trials. The recent one-year follow-up of this randomized trial published in the Lancet confirms that the invasive strategy rapidly transforms unstable coronary-artery disease into a stable condition, lowering long-te

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New York, July 5, 2000 (Praxis Press) Continuous renal replacement therapies (CRRT) are increasingly replacing intermittent hemodialysis or peritoneal dialysis in the treatment of acute renal failure in critically ill patients. However, there is no consensus on the appropriate treatment dose or the impact of dose delivery on outcome. In a prospective randomized trial, Ronco et al determined that an increase in the rate of ultrafiltration in continuous veno-venous hemofiltration significantly im

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New York, June 30, 2000 (Praxis Press) Mortality rates from coronary artery disease (CAD), abnormal ventricular function and unsustained ventricular tachycardia are high. In patients with a history of myocardial infarction, cardiac arrest is often the result of reentrant ventricular tachycardia or fibrillation. Studies have not clearly assessed the prognostic value of electrophysiologic testing for these cases. In the Multicenter Unsustained Tachycardia Trial, Buxton et al performed electrophys

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New York, June 30, 2000 (Praxis Press) In familial adenomatous polyposis (FAP), a genetic disease that spurs the formation of hundreds of adenomatous polyps in the colon, the risk of developing colorectal cancer verges on 100 percent. Nonsteroidal antiinflammatory drugs (NSAIDs) are linked to a lower incidence of adenomatous polyps and lower colon cancer mortality, possibly due to their inhibition of the cyclooxygenase enzyme family, but their gastrointestinal toxicity limits their long-term use

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