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genome sequence will help in developing protection against the disease. Robert Walgate discovers that it might - but perhaps not in the most obvious ways.

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NEW YORK, August 3 (Praxis Press) The antipsychotic drug, Mellaril (thioridazine) has been shown to prolong patients' QTc interval, which can lead to a type of ventricular tachycardia known as torsades de pointes and potentially sudden death. At the request of the US Food and Drug administration (FDA), the manufacturer of the drug, Novartis, has now added a black box warning on the drug's label in order to alert physicians to its tendency of prolonging a patient's heartbeat interval. Now Mellari

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Thrombolytic therapy

August 8, 2000

NEW YORK, August 7 (Praxis Press) Thrombolytic therapy for acute myocardial infarction is equally effective when delivered as a bolus injection and as a 60 to 90-minute infusion; however, the relative safety of these two delivery methods is unknown. Using meta-analysis, Mehta and colleagues studied the risk of intracranial hemorrhage in patients receiving thrombolytic therapy as a bolus or as an infusion. The analysis included seven randomized trials with a total of 103,972 patients. The risk of

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Recommend a tuberculin skin test to patients returning from regions where tuberculosis is endemic.

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Bill Gates is opening windows on world health

By | August 7, 2000

Tropical Medicine for malaria was 20 times the size of the School's usual receipts.

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Breeding a better vector

By | August 7, 2000

DNA shuffling (also called molecular breeding) generates variation by random fragmentation of a cloned gene followed by reassembly of the fragments in a self-priming polymerase reaction. The result is a recombination of overlapping fragments that have different mutations or come from different, naturally occurring homologous genes. In the August Nature Genetics Soong et al apply this technique to a pool of six different murine leukemia virus envelope sequences to derive a new virus that can,

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Profiles of metastasis

By | August 7, 2000

DNA microarray analysis of metastatic cells reveals a new player, and an expression profile characteristic of reduced motility and invasive ability.

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The two chromosomes of cholera

By | August 7, 2000

suggests that the bacterium's second chromosome may have started life as a megaplasmid.

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Better evaluation of health risks associated with cell phones is necessary.

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Esophageal adenocarcinoma

August 3, 2000

Reflux-promoting drugs may raise risk for esophageal adenocarcinoma.

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