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Hippocampus arrays

By | July 5, 2001

The hippocampus plays a role in the brain's ability to learn and remember. In the Early Edition of the Proceedings of the National Academy of Sciences, Mody et al. report the use of a microarray strategy to define genes involved in the development and function of the mouse hippocampus. They used Affymetrix oligonucleotide arrays to screen for the expression profiles of 11,000 genes in embryonic (E16) or postnatal (P1, P7, P16 and P30) mouse hippocampus tissue. They found that 1,926 genes showed

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Caught by the secretory-trap

By | July 4, 2001

The gene-trap strategy can exploit insertional mutagenesis to allow phenotypic screening. In the July issue of Nature Genetics, Mitchell et al. demonstrate the power of gene-trap mutagenesis for genome-wide analysis of the genes involved in mouse development (Nature Genetics 2001, 298:241-24). Their modified 'secretory-trap' vector selects genes that have secretory signal sequences or transmembrane domains. Screening over 500 insertions in mouse embryonic stem (ES) cells identified 187 individua

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The Royal Society Summer Exhibition 2001

By | July 4, 2001

The scientific equivalent of the Royal Academy's Summer Exhibition is underway at Carlton Gardens with over 20 fascinating topics to choose from.

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Deadly fusion

By | July 3, 2001

Translocations in acute megakaryoblastic leukemia result in the fusion of two novel genes.

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Nicotine promotes tumour growth and atherosclerosis

By | July 3, 2001

Treatment for nicotine addiction may be as harmful as smoking, as nicotine seems to promote angiogenesis and tumour formation.

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Degrading mutations

By | July 2, 2001

Mutations in matrix metalloproteases have been detected in inherited osteolytic and arthritic disorder.

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Minor histocompatibility antigen has anti-leukaemic role

By | July 2, 2001

have curative anti-leukaemia activity through a graft-versus-leukaemia effect with no graft-versus-host disease.

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Pollen coat protein gene families

By | July 2, 2001

Clusters of pollen coat protein genes could help define species and prevent non-specific pollination.

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Id and aging

By | June 29, 2001

The Id1 protein inhibits cell senescence by repressing cell-cycle genes.

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Nitric oxide holds the key to firefly glow

By | June 29, 2001

Nitric oxide was once regarded simply as a noxious pollutant. But its ever expanding functional repertoire may now include generation of firefly luminescence.

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