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more than just a problem with chloride ions

By | March 1, 2001

ion transport in cystic fibrosis has important implications for treatment of this debilitating condition.

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Early breast cancer detection

By | February 28, 2001

Early detection is critical for the clinical management of breast cancer. In the February 27 Proceedings of the National Academy of Science, Martin et al. describe a highly sensitive blood-based assay to detect and classify solid tumours (Proc Natl Acad Sci USA 2001, 98:2646-2651). The high-throughput assay involves a two-step approach, combining differential display with cDNA microarrays. Martin et al. analysed blood samples from 26 breast cancer patients for the expression of 12 breast can

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Preference for one's own kind?

By | February 28, 2001

Genetic studies show that eels from different parts of the world don't mate in a free-for-all once they reach the Sargasso Sea.

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Gene for DiGeorge syndrome

By | February 27, 2001

DiGeorge syndrome (DGS; also known as Velo-cardio-facial syndrome) is associated with hemizygous deletion of a region of human chromosome 22q11, causing a range of abnormalities including cardiovascular defects, hypoplasia of the thymus and parathyroid gland, and craniofacial abnormalities.Three research groups have identified the TBX1 gene, a member of the T-box family of transcription factors, as a key determinant of the DGS phenotype. Merscher et al. (Cell 2001, 104:619-629) and Lindsay et al

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Houston aims to become biotechnology center

By | February 27, 2001

In a bid to rival San Diego and Boston as a centre for biomedical research and technology transfer, Houston has just announced the $633 million, 64-acre Southeast Texas Biotechnology Park.

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The dynamics of interacting populations

By | February 27, 2001

An experimental model shows how the strength of the interaction between a prey and a specialist predator affects the population dynamics of the system.

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A therapeutic target for Alzheimer's disease

By | February 26, 2001

peptide, which makes up the characteristic brain plaques of Alzheimer's disease, is not secreted by neurons from mice that lack the BACE1 secretase.

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Call for reintroduction of single vaccines for mumps, measles and rubella

By | February 26, 2001

A UK survey on the use of the combined mumps, measles and rubella (MMR) vaccine reveals that four out of 10 GPs would like to see single vaccines available as an alternative.

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cancer mutations influence gene expression

By | February 26, 2001

express different groups of genes, suggesting that a heritable mutation influences the gene-expression profile of the cancer.

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Paris, profit and potential

By | February 26, 2001

A UNESCO meeting in Paris last week discussed the potential of electronic publishing in science. There have been some strong movements in biomedical publishing in the past five years but nothing like the seismic shift that's needed, concludes physicist Paul Ginsparg.

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