Advertisement
PerkinElmer
PerkinElmer

News & Opinion

Covering the life sciences inside and out

Most Recent

Alzheimer's disease protein isolated

By | September 7, 2000

A new protein that might be involved in generating the amyloid plaques in Alzheimer's disease has been identified.

0 Comments

Cyanide used to attack tumours

By | September 7, 2000

An enzyme derived from the cassava plant could be used to selectively destroy cancer cells.

0 Comments

Antibody arrays

By | September 6, 2000

Protein arrays are lagging behind in their implementation relative to DNA arrays because proteins are harder to produce and keep active. But in the September Nature Biotechnology de Wildt et al. describe the use of robotic spotting to produce antibody arrays, using bacterial colonies that produce single-chain antibodies (Nat. Biotechnol. 2000, 18:989-994). Up to 18,342 antibody clones can be screened at one time, and the same antibody-producing cells can easily be spotted onto up to 15 replicate

0 Comments

Double-duplication evolution

By | September 6, 2000

In the 1 September Science Lang et al. argue that two single-domain biosynthetic enzymes appear to have evolved from gene duplication, followed by fusion, followed by a second gene duplication (Science 2000, 289:1546-1550). Both of the proteins, HisA and HisF, can be broken down into two half beta/alpha barrels. The four half barrels can be superimposed on each other, revealing 22% identical or similar residues. As both enzymes bind biphosphate substrates, each half barrel has a phosphate-bindin

0 Comments

Repair polymerases in a double act

By | September 6, 2000

Two eukaryotic DNA polymerases act sequentially to repair DNA lesions.

0 Comments

A potential therapeutic mechanism for regulating cholesterol uptake

By | September 5, 2000

Retinoid receptors play a key part in cholesterol homeostasis.

0 Comments

Parkinson's disease not restricted to the brain

By | September 5, 2000

LONDON, September 5 (SPIS MedWire). Parkinson's disease may not be restricted to the brain; it could also cause the loss of nerve terminals in the heart, according to new research. Scientists at the National Institute of Neurological Disorders and Stroke (NINDS), Maryland, USA, carried out positron emission tomography scans on 29 Parkinson's disease patients. Nearly all had reduced numbers of norepinephrine-producing nerve endings in the heart. This decrease was not related to whether the patien

0 Comments

Cholesterol levels drop after myocardial infarction

By | September 4, 2000

A recent study suggests that lipids should be measured routinely on admission in acute coronary syndromes.

0 Comments

Creating protein folds

By | September 4, 2000

An exon, the basic unit of DNA that gets shuffled around during evolution, has an average coding capacity of 40 amino acids, or roughly half of a small folded protein domain. Exon exchange between homologous proteins can lead to slightly altered proteins, but in the August 29 Proceedings of the National Academy of Sciences Riechmann and Winter ask whether shuffling between unrelated sequences can generate new folds (Proc Natl Acad Sci USA 2000, 97:10068-10073). Their starting material is DNA enc

0 Comments

Keep taking the pills

By | September 4, 2000

The placebo effect may lead to a significant skew in clinical trials of heart treatments.

0 Comments

Advertisement
Thermo Scientific
Thermo Scientific

Popular Now

  1. Antibiotics and the Gut Microbiome
  2. Sex Differences in Pain Pathway
  3. The Sum of Our Parts
    Features The Sum of Our Parts

    Putting the microbiome front and center in health care, in preventive strategies, and in health-risk assessments could stem the epidemic of noncommunicable diseases.

  4. Anti-Vax Doctor Found Dead
    The Nutshell Anti-Vax Doctor Found Dead

    Police are calling the death of James Bradstreet, a physician who claimed vaccines cause autism and offered autism cures to patients, an apparent suicide.

Advertisement
Advertisement
The Scientist